Results 251 to 260 of about 46,200 (286)
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Nature Microbiology, 2020
N6-methyladenosine (m6A) is a widespread modifcation on cellular RNA that is dynamically regulated involving m6A writers, erasers and readers, and can impact many cellular processes and pathways.
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N6-methyladenosine (m6A) is a widespread modifcation on cellular RNA that is dynamically regulated involving m6A writers, erasers and readers, and can impact many cellular processes and pathways.
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Role of m6A methylation in retinal diseases
Experimental Eye Research, 2023Retinal diseases remain among the leading causes of visual impairment in developed countries, despite great efforts in prevention and early intervention. Due to the limited efficacy of current retinal therapies, novel therapeutic methods are urgently required. Over the past two decades, advances in next-generation sequencing technology have facilitated
Xinyu Zhu +3 more
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Nature Chemical Biology, 2019
The N6-methyladenosine modification on RNA affects almost all steps of RNA metabolism. A new approach, using the CRISPR-based technology to modulate m6A level in mRNA, enables direct functional interrogation of site-specific m6A.
Jiangbo Wei, Chuan He
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The N6-methyladenosine modification on RNA affects almost all steps of RNA metabolism. A new approach, using the CRISPR-based technology to modulate m6A level in mRNA, enables direct functional interrogation of site-specific m6A.
Jiangbo Wei, Chuan He
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Biochemical and Biophysical Research Communications, 2019
Osteosarcoma(OS) is the most common and aggressive malignant bone sarcoma,which occurs in rapidly growing bones in children and adolescents. However, the underlying molecular mechanisms of OS development have not been fully illustrated. N6-Methyladenosine (m6A) is the most prevalent internal chemical modification of mRNAs, which is involved in many ...
Wujun, Miao +4 more
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Osteosarcoma(OS) is the most common and aggressive malignant bone sarcoma,which occurs in rapidly growing bones in children and adolescents. However, the underlying molecular mechanisms of OS development have not been fully illustrated. N6-Methyladenosine (m6A) is the most prevalent internal chemical modification of mRNAs, which is involved in many ...
Wujun, Miao +4 more
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N6‐methyladenosine (m6A) Modification in Preeclampsia
Reproductive Sciences, 2023Recently, epitranscriptional modification of N6-methyladenosine (m6A) has received growing attention in the research on the pathogenesis of preeclampsia. Advances in m6A sequencing have revealed the molecular mechanism and importance of m6A modification.
Tingting Zhang +6 more
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RNA m6A methylation across the transcriptome
Molecular Cell, 2023Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of these chemical modifications, N6-methyl adenosine (m6A), is unique in a way that it is highly abundant not only on RNA polymerase II (RNAPII) transcribed, protein-coding ...
Erdem, Sendinc, Yang, Shi
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RNA m6A methylation regulators in sepsis
Molecular and Cellular Biochemistry, 2023N6-methyladenosine (m6A) modification is a class of epitope modifications that has received significant attention in recent years, particularly in relation to its role in various diseases, including sepsis. Epigenetic research has increasingly focused on m6A modifications, which is influenced by the dynamic regulation of three protein types: ‟Writers" (
Lin, Zhu +3 more
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Relative Quantification of Residue-Specific m6A RNA Methylation Using m6A-RT-QPCR
2021Technological advances in high-throughput sequencing in combination with antibody enrichment and/or induced nucleotide-specific chemical modifications have accelerated the mapping of epitranscriptomic modifications. However, site-specific detection and quantification of m6A are still technically challenging.
Ane, Olazagoitia-Garmendia +1 more
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Determinants of the m6A Epitranscriptome
2021N6–methyladenosine (m6A) is the most abundant mRNA modification and is crucial for gene expression regulation in numerous biological processes. In mammals, m6A methylation is specifically deposited on a subset of mRNAs and is strongly enriched within long internal exons and near stop codons.
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m6A nuclear condensates support AML
Nature Reviews Molecular Cell Biology, 2021Nuclear condensates of m6A-methylated mRNAs with their ‘reader’ YTHDC1 prevent the degradation of acute myeloid leukaemia-promoting mRNAs by the exosome.
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