The immunosuppressive in OM Staphylococcus aureus employs multiple physical barriers to evade host immunity during skeletal infection, including biofilm formation on implant surfaces and necrotic bone tissues, invasion into the osteocyte lacuno‐canalicular network (OLCN), intracellular persistence within osteoblasts, osteoclasts, and osteocytes, and ...
Qingqiang Lei +7 more
wiley +1 more source
Experimental and Computational Tools for Mapping Circular RNA Modifications. [PDF]
Sahoo G, Santra D, Panda AC.
europepmc +1 more source
Liver Metastases from Colorectal Cancer: From Pathogenesis to Current Treatment
The liver is not merely a passive recipient of disseminated tumor cells, but a unique metastatic organ shaped by anatomical, metabolic, and immunological characteristics that support tumor colonization. Increasing evidence indicates that colorectal cancer liver metastasis development is driven by dynamic interactions between tumor intrinsic programs ...
Jialiang Fan +10 more
wiley +1 more source
Integrative multi-omics analysis unveils the regulatory landscape of diabetic cardiomyopathy: from chromatin accessibility to transcript isoforms and epitranscriptome. [PDF]
Ding L, Liu K, Ge X, Li Z, Hu K, Bu S.
europepmc +1 more source
Clinical Epigenomics in Rare Diseases: Interpreting DNA Methylation Episignatures
Clinical epigenomics extends rare‐disease diagnostics beyond DNA sequence by revealing the downstream regulatory consequences of genetic variation. DNA methylation episignatures provide functional evidence that can support diagnosis, refine variant interpretation, distinguish overlapping disorders, and complement genomic, and multi‐omic testing ...
Himanshu Goel, Shuxiang Goh, Luke Stuart
wiley +1 more source
Identification of Rice m<sup>6</sup>A Methyltransferase Complex Subunits MTA/MTB and Their Effects on Heading Date and Grain Weight. [PDF]
Li C +8 more
europepmc +1 more source
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen +4 more
wiley +1 more source
m<sup>6</sup>A modification in immune-cell inflammatory fate: from RNA fate regulation to therapeutic translation in inflammatory diseases. [PDF]
Zhu Y, Yang S, Qin L, Ding D, Gan X.
europepmc +1 more source
Chronic nitric oxide mediates dual-layer gene regulation through mRNA m<sup>6</sup>A positional remodeling and parallel transcriptional reprogramming. [PDF]
Shayan S +3 more
europepmc +1 more source
METTL3 Promotes Lipid Deposition and Pulmonary Fibrosis by Destabilizing PLIN2 in a m6A-Dependent Manner. [PDF]
Liu Q, Xu R, Du X.
europepmc +1 more source

