Results 21 to 30 of about 63,662 (384)
RNA modification-mediated translational control in immune cells
RNA Biology, 2023 RNA modifications play a vital role in multiple pathways of mRNA metabolism, and translational regulation is essential for immune cells to promptly respond to stimuli and adapt to the microenvironment.
Yujuan Zhang, Weiguo Hu, Hua-Bing Li
doaj +1 more source
Exon architecture controls mRNA m6A suppression and gene expression
Science, 2023 N6-methyladenosine (m6A) is the most abundant messenger RNA (mRNA) modification and plays crucial roles in diverse physiological processes. Using a massively parallel assay for m6A (MPm6A), we discover that m6A specificity is globally regulated by ...
P. He +13 more
semanticscholar +1 more source
Eye Movements Actively Reinstate Spatiotemporal Mnemonic Content
Vision, 2019 Eye movements support memory encoding by binding distinct elements of the visual world into coherent representations. However, the role of eye movements in memory retrieval is less clear.
Jordana S. Wynn +2 more
doaj +1 more source
The role of m6A methylation in therapy resistance in cancer
Molecular Cancer, 2023 Cancer therapy resistance is the main cause of cancer treatment failure. The mechanism of therapy resistance is a hot topic in epigenetics. As one of the most common RNA modifications, N6-methyladenosine (m6A) is involved in various processes of RNA ...
Hengzhao Zhuang +7 more
semanticscholar +1 more source
Exploration of Medicine, 2023 m6A RNA methylation, a predominant type of RNA modification, is involved in regulating mRNA splicing, stability, and translation as well as the interaction between nucleoproteins and noncoding RNAs.
Hiromichi Sato +10 more
doaj +1 more source
METTL3 regulates WTAP protein homeostasis [PDF]
, 2018 The Wilms tumor 1 (WT1)-associated protein (WTAP) is upregulated in many tumors, including, acute myeloid leukemia (AML), where it plays an oncogenic role by interacting with different proteins involved in RNA processing and cell proliferation.
Capuano, Ernestina +8 more
core +2 more sources
Nature Communications, 2023 m6A modification has been reported to play roles in many developmental and pathological processes, but its role in AKI remains poorly understood.
Juntao Chen +10 more
semanticscholar +1 more source
m6A-dependent regulation of messenger RNA stability
Nature, 2013 N6-methyladenosine (m6A) is the most prevalent internal (non-cap) modification present in the messenger RNA of all higher eukaryotes. Although essential to cell viability and development, the exact role of m6A modification remains to be determined.
Xiao Wang +12 more
semanticscholar +1 more source
Signal Transduction and Targeted Therapy, 2021 N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy activation is one of the ways by which cancer cells survive hypoxia.
Qing Li +10 more
semanticscholar +1 more source
Epigenetics, 2021 Accumulating evidence has demonstrated that N6-methyladenosine (m6A) plays important roles in various cancers, making it essential to profile m6A modifications at a transcriptome-wide scale in colorectal cancer (CRC).
Zhen Zhang +10 more
doaj +1 more source