Results 91 to 100 of about 24,574 (283)

The roles of RNA N6-methyladenosine in esophageal cancer

Heliyon, 2022
Esophageal cancer is a malignant tumour with a high degree of malignancy and high mortality. Its pathogenesis and treatment strategy remain unclear.
Chuan Teng, Fanhua Kong, Jinggang Mo, Weidong Lin, Chong Jin, Kunpeng Wang, Ying Wang   +6 more
doaj   +1 more source

RNA stability controlled by m6A methylation contributes to X-to-autosome dosage compensation in mammals [PDF]

, 2023
Cornelia Rücklé, Nadine Körtel, M. Felicia Basilicata, Anke Busch, You Zhou, Peter Hoch-Kraft, Kerstin Tretow, Fridolin Kielisch, Marco Bertin, Mihika Pradhan, Michael U. Musheev, Susann Schweiger, Christof Niehrs, Oliver Rausch, Kathi Zarnack, Claudia Isabelle Keller Valsecchi, Julian König   +16 more
openalex   +1 more source

RNA m6A methylation regulates the ultraviolet-induced DNA damage response [PDF]

Nature, 2017
Cell proliferation and survival require the faithful maintenance and propagation of genetic information, which are threatened by the ubiquitous sources of DNA damage present intracellularly and in the external environment. A system of DNA repair, called the DNA damage response, detects and repairs damaged DNA and prevents cell division until the repair
Xiang, Y, Laurent, B, Hsu, C-H, Nachtergaele, S, Lu, Z, Sheng, W, Xu, C, Chen, H, Ouyang, J, Wang, S, Ling, D, Hsu, P-H, Zou, L, Jambhekar, A, He, C, Shi, Y   +15 more
openaire   +2 more sources

Mitophagy and Ubiquitination Coordinate Context‐Specific Mitochondrial Quality Control and EMT/MET Plasticity to Drive Cancer Cell Invasion

Advanced Science, EarlyView.
Metastatic invasion emerges when tumor‐intrinsic programs and microenvironmental forces converge on mitochondrial quality control. A context‐stratified framework links mtROS, mtDNA integrity, mechanics and nutrient/oxygen cues to fission–fusion remodeling, mtUPR and mitophagy.
Bin‐Hsu Mao, Bo‐Kai Su, Ying‐Jan Wang, Ting‐Yuan Tu   +3 more
wiley   +1 more source

Downregulation of Methyltransferase-Like 14 Promotes Ovarian Cancer Cell Proliferation Through Stabilizing TROAP mRNA

Frontiers in Oncology, 2022
Altered expression levels of the proteins that regulate N6-methyladenosine (m6A) RNA methylation, including methyltransferase-like 14 (METTL14), are associated with cancer development.
Yize Li, Hongyan Peng, Peng Jiang, Jiarui Zhang, Yongmei Zhao, Xuelian Feng, Cui Pang, Jingyi Ren, Hongmei Zhang, Wendong Bai, Wendong Bai, Wenchao Liu   +11 more
doaj   +1 more source

PARP1 modulates METTL3 promoter chromatin accessibility and associated LPAR5 RNA m6A methylation to control cancer cell radiosensitivity [PDF]

, 2023
Xiaoya Sun, Chenjun Bai, Hao‐Zheng Li, Dafei Xie, Shi Chen, Han Yang, Jinhua Luo, Yang Li, Yumeng Ye, Jin Jia, Xin Huang, Hua Guan, Dingxin Long, Ruixue Huang, Shanshan Gao, Ping‐Kun Zhou   +15 more
openalex   +1 more source

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L., Comings D. E., Delbrück M., Rastan S., Rosspopoff O.   +4 more
core   +1 more source

The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence. [PDF]

, 2017
YTHDF2 binds and destabilizes N6-methyladenosine (m6A)-modified mRNA. The extent to which this branch of m6A RNA-regulatory pathway functions in vivo and contributes to mammalian development remains unknown.
Azzi, Chiara, Carrieri, Claudia, Di Giacomo, Monica, Enright, Anton J, Ivanova, Ivayla, Monahan, Jack, Moreira, Pedro N, Morgan, Marcos, Much, Christian, O'Carroll, Dónal   +9 more
core   +3 more sources

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Role of m6A RNA Methylation in Thyroid Cancer Cell Lines

International Journal of Molecular Sciences, 2022
N6-methyladenosine (m6A) is the most abundant internal modification of RNA in eukaryotic cells, and, in recent years, it has gained increasing attention. A good amount of data support the involvement of m6A modification in tumorigenesis, tumor progression, and metastatic dissemination.
Allegri L., Baldan F., Molteni E., Mio C., Damante G.   +4 more
openaire   +2 more sources