Results 111 to 120 of about 24,574 (283)

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

Advanced Science, EarlyView.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li, Xiangmin Tan, Yaran Liu, Yongquan He, Bo Yuan, Ping Wang, Guangzhi Ma, Mengzhe Guo, Jian Zhou, Qiang Sun   +9 more
wiley   +1 more source

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications. [PDF]

, 2015
Methylation of cytosine deoxynucleotides generates 5-methylcytosine (m(5)dC), a well-established epigenetic mark. However, in higher eukaryotes much less is known about modifications affecting other deoxynucleotides. Here, we report the detection of N(6)-
A Morgulis, Ana S H Costa, BA Braaten, BF Vanyushin, C Zang, Charles R Bradshaw, Christian Frezza, D Dominissini, D Roberts, E Ford, EL Greer, EM Reyes, EM Zdobnov, F Laengle-Rouault, G Bertani, G Zhang, GE Geier, George E Allen, H Kobayashi, H Li, J Boyes, JB Bowes, John B Gurdon, KS Pollard, L Micallef, M Lawrence, M Lu, Magdalena J Koziol, MG Marinus, MS May, PA Jones, PD Lawley, PD Thomas, PH Kay, RD Hotchkiss, S Ito, SE Luria, T Pfaffeneder, TL Bailey, TW Munns, U Gunthert, WA Cantara, WJ Kent, Y Fu, Y Gruenbaum   +44 more
core   +2 more sources

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Circadian rhythms and post-transcriptional regulation in higher plants [PDF]

, 2015
The circadian clock of plants allows them to cope with daily changes in their environment. This is accomplished by the rhythmic regulation of gene expression, in a process that involves many regulatory steps.
Romanowski, Andrés, Yanovsky, Marcelo Javier   +1 more
core   +6 more sources

Quantification of m6A RNA methylation modulators pattern was a potential biomarker for prognosis and associated with tumor immune microenvironment of pancreatic adenocarcinoma

BMC Cancer, 2021
Background m6A is the most prevalent and abundant form of mRNA modifications and is closely related to tumor proliferation, differentiation, and tumorigenesis. In this study, we try to conduct an effective prediction model to investigated the function of
Lianzi Wang, Shubing Zhang, Huimin Li, Yang Xu, Qiang Wu, Jilong Shen, Tao Li, Yuanhong Xu   +7 more
doaj   +1 more source

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis [PDF]

, 2017
Circular RNAs (circRNAs) constitute a family of transcripts with unique structures and still largely unknown functions. Their biogenesis, which proceeds via a back-splicing reaction, is fairly well characterized, whereas their role in the modulation of ...
Andronache, Adrian, Bozzoni, Irene, Briganti, Francesca, DI TIMOTEO, Gaia, Fatica, Alessandro, Laneve, Pietro, Legnini, Ivano, Morlando, Mariangela, Rajewsky, Nikolaus, Rossi, Francesca, Santini, Tiziana, Sthandier, Olga Elena, Wade, Mark   +12 more
core   +3 more sources

Rational Design Strategies for Stimuli‐Responsive DNAzymes Using Modified and Artificial Nucleotides

Chemistry – A European Journal, EarlyView.
Activity control of RNA‐cleaving DNAzymes in response to external stimuli has attracted growing interest for applications in DNA‐based diagnostics, therapeutics, and dynamic DNA nanotechnology. This review summarizes rational design strategies for stimuli‐responsive DNAzymes using modified or artificial nucleotides, including split and caged DNAzymes ...
Yusuke Takezawa, Mitsuhiko Shionoya
wiley   +1 more source

Comprehensive analysis of m6A RNA methylation regulators in esophageal carcinoma. [PDF]

Transl Cancer Res
N6-methyladenosine (m6A) is the most pervasive modification of RNA methylation in eukaryotic cells. m6A modification plays a pivotal role in tumorigenesis and progression in many types of cancers. Until now, the role of m6A modification in esophageal carcinoma (ESCA) has remained obscure.
Yang H, Liu J, Li L, Wang X, Wang X, Li Z.   +5 more
europepmc   +3 more sources

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond [PDF]

, 2015
The AlkB family of Fe(II)- and α-ketoglutarate-dependent dioxygenases is a class of ubiquitous direct reversal DNA repair enzymes that remove alkyl adducts from nucleobases by oxidative dealkylation.
Delaney, James C., Essigmann, John M., Fedeles, Bogdan I., Li, Deyu, Singh, Vipender   +4 more
core   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source