Results 91 to 100 of about 937,277 (225)

Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway

Journal of Translational Medicine, 2023
Background Denervation-induced muscle atrophy is complex disease involving multiple biological processes with unknown mechanisms. N6-methyladenosine (m6A) participates in skeletal muscle physiology by regulating multiple levels of RNA metabolism, but its
Junjie Sun, Hai Zhou, Zehao Chen, Han Zhang, Yanzhe Cao, Xinlei Yao, Xin Chen, Boya Liu, Zihui Gao, Yuntian Shen, Lei Qi, Hualin Sun   +11 more
doaj   +1 more source

The regulatory role of N6-methyladenosine RNA modification in gastric cancer: Molecular mechanisms and potential therapeutic targets

Frontiers in Oncology, 2022
N6-methyladenosinen (m6A) methylation is a frequent RNA methylation modification that is regulated by three proteins: “writers”, “erasers”, and “readers”. The m6A modification regulates RNA stability and other mechanisms, including translation, cleavage,
Gaofeng Li, Qiru Fu, Cong Liu, Yuxi Peng, Jun Gong, Shilan Li, Yan Huang, Haiyuan Zhang   +7 more
doaj   +1 more source

Epitranscriptomic(N6-methyladenosine) Modification of Viral RNA and Virus-Host Interactions

Frontiers in Cellular and Infection Microbiology, 2020
N6-methyladenosine (m6A) is the most prevalent and internal modification of eukaryotic mRNA. Multiple m6A methylation sites have been identified in the viral RNA genome and transcripts of DNA viruses in recent years.
Hasan Imam, Geon-Woo Kim, Aleem Siddiqui
doaj   +1 more source

Identification of the Role and Clinical Prognostic Value of Target Genes of m6A RNA Methylation Regulators in Glioma

Frontiers in Cell and Developmental Biology, 2021
m6A RNA methylation regulators can regulate the growth, progression, and invasion of glioma cells by regulating their target genes, which provides a reliable support for the m6A regulator–target axes as the novel therapeutic targets and clinical ...
Peilin Cong, Ting-Jian Wu, Xin-Wei Huang, Hua-Zheng Liang, Xiaofei Gao, Libin Tian, Wanrong Li, Ai-Ping Chen, H. Wan, Mengfan He, Danqing Dai, Zhen Li, Li-Ze Xiong   +12 more
semanticscholar   +1 more source

Alteration of N6-Methyladenosine mRNA Methylation in a Human Stem Cell-Derived Cardiomyocyte Model of Tyrosine Kinase Inhibitor-Induced Cardiotoxicity

Frontiers in Cardiovascular Medicine, 2022
BackgroundN6-methyladenosine (m6A) plays important roles in various cardiovascular diseases (CVDs), including cardiac hypertrophy and heart failure. Sunitinib (SUN) is a tyrosine kinase inhibitor (TKI) that is widely used in the treatment of different ...
Yan Ma, Xian Liu, Yiming Bi, Tianhu Wang, Cheng Chen, Yabin Wang, Dong Han, Feng Cao   +7 more
doaj   +1 more source

piRNA-30473 contributes to tumorigenesis and poor prognosis by regulating m6A RNA methylation in DLBCL.

Blood, 2020
The initiation and progression of diffuse large B-cell lymphoma (DLBCL) is governed by genetic and epigenetic aberrations. As the most abundant eukaryotic message RNA modification, N6-methyladenosine (m6A) is known to influence various fundamental ...
Huiying Han, Gao Fan, Sha Song, Yun-Wei Jiang, Chen'ao Qian, Wei-Min Zhang, Q. Su, X. Xue, Wen-Zhuo Zhuang, Bing-Zong Li   +9 more
semanticscholar   +1 more source

m6A RNA methylation-mediated NDUFA4 promotes cell proliferation and metabolism in gastric cancer

Cell Death and Disease, 2022
Gastric cancer (GC) is a malignancy with poor prognosis. NDUFA4 is reported to correlate with the progression of GC. However, its underlying mechanism in GC is unknown. Our study was to reveal the pathogenic mechanism of NDUFA4 in GC.
Wei-Hong Xu, Y. Lai, Yunqi Pan, Meiyu Tan, Yan-Yun Ma, Hui-Ming Sheng, Jiu-Cun Wang   +6 more
semanticscholar   +1 more source

RNA m6A methylation regulators in liver cancer

Cancer Cell International
AbstractLiver cancer is one of the most common cancers in the world and a primary cause of cancer-related death. In recent years, despite the great development of diagnostic methods and targeted therapies for liver cancer, the incidence and mortality of liver cancer are still on the rise.
Qiaoping Xu, Ning Ren, Lanqi Ren, Yibei Yang, Junjie Pan, Hongkai Shang   +5 more
openaire   +3 more sources

m6A-Driver: Identifying Context-Specific mRNA m6A Methylation-Driven Gene Interaction Networks. [PDF]

, 2016
As the most prevalent mammalian mRNA epigenetic modification, N6-methyladenosine (m6A) has been shown to possess important post-transcriptional regulatory functions.
Meng, Jia, Lian Liu, Zhang, Shao-Wu, Shao-Wu Zhang (2901425), Song-Yao Zhang, Liu, Lian, Huang, Yufei, Shao-Wu Zhang, Yufei Huang (195878), Song-Yao Zhang (3708619), Lian Liu (371908), Zhang, Song-Yao, Jia Meng (306948), Jia Meng, Yufei Huang   +14 more
core   +1 more source

Transcriptome-wide m6A methylation in natural yellow leaf of Catalpa fargesii

Frontiers in Plant Science, 2023
N6-methyladenosine (m6A) is the most abundant internal modification in eukaryotic messenger RNA, and involved in various biological processes in plants. However, the distribution features and functions of mRNA m6A methylation have been poorly explored in
Yu Zhang, Junhui Wang, Wenjun Ma, Nan Lu, Pengyue Fu, Yingying Yang, Linjiao Zhao, Jiwen Hu, Guanzheng Qu, Nan Wang   +9 more
doaj   +1 more source