Results 121 to 130 of about 24,574 (283)

Global m6A RNA and whole 5mC DNA methylation specifically contribute to cell replicative and premature senescence induced by extrinsic oxidative stress

mSystems
Hydrogen peroxide (H2O2) is a typical representative substance of environmental oxidative stress. Exogenous substances can alter epigenetic modifications from the DNA to the RNA level through oxidative stress.
Chenyu Zhu, Tingting Huang, Jiaqi Fu, Min Li, Luyi Tan, Xinyu Zhang, Wenli Cheng, Caiyun Lai, Zhangying Wang, Wenji Zhang, Wenjuan Zhang   +10 more
doaj   +1 more source

Control of box C/D snoRNP assembly by N⁶-methylation of adenine [PDF]

, 2017
N6-methyladenine is the most widespread mRNA modification. A sub-set of human box C/D snoRNA species have target GAC sequences that lead to formation of N6-methyladenine at a key trans Hoogsteen-sugar A•G basepair, of which half are methylated in vivo ...
Bokar JA, David MJ Lilley, Jia Wang, Lin Huang, Nicholas KB, Saira Ashraf   +5 more
core   +1 more source

Advanced extracellular vesicle immunotherapy

FlexMat, EarlyView.
A diagrammatic depiction of the therapeutic applicability of extracellular vesicles (EVs) in immunotherapy. This review explores the dual roles of tumor‐derived and immune cell‐derived EVs in cancer immunotherapy, discusses recent progress in EV engineering that improve their clinical utility, and evaluates their potential to augment existing ...
Jingjing Zhang, Yunfei Mu, Xianyue Ji, Xiaoting Jiang, Ruiheng Wang, Xianguang Ding, Lianhui Wang   +6 more
wiley   +1 more source

Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation

Cell Reports, 2018
Summary: Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis, disruptions of which can lead to metabolic diseases. Whether N6-methyladenosine (m6A) mRNA methylation impacts circadian regulation of lipid metabolism
Xiang Zhong, Jiayao Yu, Katya Frazier, Xiaocheng Weng, Yi Li, Candace M. Cham, Kyle Dolan, Xiaorong Zhu, Nathaniel Hubert, Yun Tao, Fanfei Lin, Kristina Martinez-Guryn, Yong Huang, Tian Wang, Jianzhao Liu, Chuan He, Eugene B. Chang, Vanessa Leone   +17 more
doaj   +1 more source

Intelligent biology and medicine in 2015: advancing interdisciplinary education, collaboration, and data science [PDF]

, 2016
We summarize the 2015 International Conference on Intelligent Biology and Medicine (ICIBM 2015) and the editorial report of the supplement to BMC Genomics. The supplement includes 20 research articles selected from the manuscripts submitted to ICIBM 2015.
Jianhua Ruan, Kun Huang, Lang Li, Lee Cooper, Yufei Huang, Yunlong Liu, Zhongming Zhao   +6 more
core   +3 more sources

Tumor‐educated platelets in cancer diagnostics and prognostics: A critical appraisal and roadmap for clinical translation

International Journal of Cancer, EarlyView.
Abstract Tumor‐educated platelets (TEPs) are emerging as a compelling frontier in liquid biopsy, functioning as dynamic, systemic sensors that sequester and process tumor‐derived biomolecules. This interaction imprints an integrated molecular signature of malignancy—spanning the transcriptome, proteome, lipidome, and crucially, the captured genome ...
Whi‐An Kwon, Min‐Kyung Lee, Eunyong Ahn, Heeyeon Kim, Yong Sang Song, Taejin Ahn   +5 more
wiley   +1 more source

Effect of methylation of adenine N6 on kink turn structure depends on location [PDF]

, 2019
N6-methyladenine is the most common covalent modification in cellular RNA species, with demonstrated functional consequences. At the molecular level this methylation could alter local RNA structure, and/or modulate the binding of specific proteins.
Bokar JA, David M. J. Lilley, Lin Huang, Saira Ashraf   +3 more
core   +2 more sources

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

iMetaMed, EarlyView.
As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu, Cenlan Bu, Qinzheng Xu, Xi Cheng, Junrong Zhang, Jinling Chen, Yun‐Zhao Xu   +6 more
wiley   +1 more source

The critical role of m6A methylation in the pathogenesis of Graves' ophthalmopathy

Eye and Vision, 2020
Purpose To investigate the role of N6-methyladenosine (m6A) RNA modification in the pathogenesis of Graves' ophthalmopathy (GO). Methods Surgically excised extraocular muscles from 7 patients with GO and 5 subjects without GO were used.
Li Zhu, Siyan Li, Shikun He, Qizhe Tong, Lejin Wang, Xiaohua Li, Xi Wu, Qingyu Meng, Enzhong Jin, Chuan Zhang, Tianyuan Li, Ningda Xu, Lvzhen Huang, Yi Wang, Mingwei Zhao   +14 more
doaj   +1 more source

The lncRNA MIAT regulates CPT-1a mediated cardiac hypertrophy through m6A RNA methylation reading protein Ythdf2 [PDF]

, 2022
Yiqing Yang, Muisha B. Mbikyo, Junzhe Zhang, Yuan Zhang, Naijin Zhang, Zhao Li   +5 more
openalex   +1 more source