Results 11 to 20 of about 2,924,807 (328)

The Current Role and Future Applications of Machine Perfusion in Liver Transplantation

Bioengineering, 2023
The relative paucity of donor livers suitable for transplantation has sparked innovations to preserve and recondition organs to expand the pool of transplantable organs.
Sebastian M. Staubli, Carlo D. L. Ceresa, Joerg M. Pollok   +2 more
doaj   +2 more sources

Resuscitation of ischemic donor livers with normothermic machine perfusion: a metabolic flux analysis of treatment in rats. [PDF]

PLoS ONE, 2013
Normothermic machine perfusion has previously been demonstrated to restore damaged warm ischemic livers to transplantable condition in animal models. However, the mechanisms of recovery are unclear, preventing rational optimization of perfusion systems ...
Maria-Louisa Izamis, Herman Tolboom, Basak Uygun, Francois Berthiaume, Martin L Yarmush, Korkut Uygun   +5 more
doaj   +10 more sources

Improved Normothermic Machine Perfusion After Short Oxygenated Hypothermic Machine Perfusion of Ischemically Injured Porcine Kidneys

Transplantation Direct, 2021
Background. In an era where global kidney shortage has pushed the field of transplantation towards using more marginal donors, modified kidney preservation techniques are currently being reviewed.
Stina Lignell, MD, Stine Lohmann, MD, Kaithlyn M. Rozenberg, BSc, Henri G. D. Leuvenink, PhD, Merel B. F. Pool, MD, Kate R. Lewis, MSc, Cyril Moers, MD, PhD, James P. Hunter, MD, Bsc(hons), Rutger J. Ploeg, MD, PhD, Marco Eijken, PhD, Ulla Møldrup, MD, Søren Krag, PhD, Carla C. Baan, PhD, Bjarne Kuno Møller, MD, PhD, Anna Krarup Keller, MD, PhD, Bente Jespersen, MD, PhD   +15 more
doaj   +5 more sources

Machine perfusion in liver transplantation.

Cochrane Database of Systematic Reviews, 2023
BACKGROUND Liver transplantation is the only chance of cure for people with end-stage liver disease and some people with advanced liver cancers or acute liver failure.
S. Tingle, Joseph Dobbins, Emily R. Thompson, Rodrigo S Figueiredo, B. Mahendran, Sanjay Pandanaboyana, C. Wilson   +6 more
semanticscholar   +3 more sources

The Landscape of In Situ and Ex Situ Machine Perfusion Utilization for Liver Grafts From Noncardiac Donation After Circulatory Death Donors in the Early era of Machine Perfusion in the United States [PDF]

Transplantation Direct
Background. Donation after circulatory death (DCD) is the major contributor to the growth in deceased organ donation in the United States. Normothermic regional perfusion (NRP) and ex situ machine perfusion (es-MP) have been vital for improving organ ...
Anji Wall, MD, PhD, Jinyu Du, PhD, Matthew Snoddy, MS, Johanna Bayer, MD, Sebastian Danobeitia, MD, PhD, Seung Hee Lee, MD, Eric Martinez, MD, Amar Gupta, MD, Gege Ran, MD, William F Parker, MD, MS, Sumeet Asrani, MD, MSCI, Giuliano Testa, MD, MBA   +11 more
doaj   +2 more sources

A Comprehensive Review of Ex-Vivo Machine Perfusion in Uterus Transplantation [PDF]

Transplant International
Uterine transplantation has revolutionized previously incurable causes of infertility. While most transplants are performed with live donors, the use of deceased donors could potentially expand the donor pool and increase the number of transplants ...
Eleni M. Drivas, Siavash Khaki, Amanda H. Loftin, Amanda H. Loftin, Narges Lamsehchi, Liza Johannesson, Byoung Chol Oh, Gerald Brandacher, Gerald Brandacher   +8 more
doaj   +2 more sources

Ex-vivo Kidney Machine Perfusion: Therapeutic Potential [PDF]

Frontiers in Medicine, 2021
Kidney transplantation remains the gold standard treatment for patients suffering from end-stage kidney disease. To meet the constantly growing organ demands grafts donated after circulatory death (DCD) or retrieved from extended criteria donors (ECD ...
Ruta Zulpaite, Ruta Zulpaite, Povilas Miknevicius, Povilas Miknevicius, Bettina Leber, Kestutis Strupas, Philipp Stiegler, Peter Schemmer   +7 more
doaj   +4 more sources

Hypothermic machine perfusion in liver transplantation [PDF]

International Journal of Surgery, 2020
Dynamic preservation strategies are a promising option to improve graft quality before transplantation, and to extend preservation time for either logistic or treatment reasons. In contrast to normothermic oxygenated perfusion, which intends to mimic physiological conditions in the human body, with subsequent clinical application for up to 24 hrs ...
Karangwa, S, Panayotova, G, Dutkowski, P, Porte, R J, Guarrera, J V, Schlegel, A   +5 more
  +9 more sources

Machine Perfusion of the Liver: A Review of Clinical Trials

Frontiers in Surgery, 2021
Although efforts have been made by transplant centers to increase the pool of available livers by extending the criteria of liver acceptance, this practice creates risks for recipients that include primary non-function of the graft, early allograft ...
Nikolaos Serifis, Rudy Matheson, Daniel Cloonan, Charles G. Rickert, James F. Markmann, Taylor M. Coe   +5 more
doaj   +1 more source

The role of oxygenation in kidney and liver machine perfusion

Трансплантология (Москва), 2023
Background. Organ transplantation is the optimal decision for patients in the end stage of many diseases. Certain conditions are required for the transportation and preservation of a donor organ after explantation, including factors such as temperature ...
M. S. Novruzbekov, A. G. Balkarov, E. Yu. Anosova, I. V. Dmitriev, Yu. A. Anisimov, N. S. Zhuravel, E. V. Klychnikova, A. S. Bogdanova, B. I. Yaremin   +8 more
doaj   +1 more source