Discovery and biological confirmation of a highly divergent Tacaribe virus in metatranscriptomic data from neotropical bats. [PDF]
Fischer C +8 more
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The detection of lymphocytic choriomeningitis virus sampled on illegal waste sites in Istria peninsula [PDF]
Hasić, Sandra
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Coadministration of LHF-535 and favipiravir protects against experimental Junín virus infection and disease. [PDF]
Westover JB +6 more
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Self-Replicating Alphaviruses: From Pathogens to Therapeutic Agents. [PDF]
Lundstrom K.
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Epidemiology of Machupo Virus Infection
American Journal of Tropical Medicine and Hygiene, 1965Summary The localities in Bolivia from which cases of hemorrhagic fever have been reported are farming communities with characteristic ecological features. The rodent, Calomys callosus, is an important reservoir host of the Machupo virus. An experimental program of disease control was successfully carried out in San Joaquin, Beni, Bolivia.
exaly +10 more sources
Bivalent Junin & Machupo experimental vaccine based on alphavirus RNA replicon vector
Junin (JUNV) and Machupo (MACV), two mammalian arenaviruses placed on the 2018 WHO watch list, are prevalent in South America causing Argentine and Bolivian hemorrhagic fevers (AHF and BHF), respectively. The live attenuated JUNV vaccine, Candid #1, significantly reduced the incidence of AHF.
Dylan M Johnson +2 more
exaly +3 more sources
Unusual Molecular Architecture of the Machupo Virus Attachment Glycoprotein [PDF]
ABSTRACTNew World arenaviruses, which cause severe hemorrhagic fever, rely upon their envelope glycoproteins for attachment and fusion into their host cell. Here we present the crystal structure of the Machupo virus GP1 attachment glycoprotein, which is responsible for high-affinity binding at the cell surface to the transferrin receptor.
Thomas A Bowden +2 more
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Chronic Infection of Rodents by Machupo Virus
Science, 1965Machupo virus, the etiologic agent of human hemorrhagic fever in Bolivia, induced chronic asymptomatic infection in laboratory hamsters and colonized individuals of the peridomestic, wild, South American rodent, Calomys callosus . Viruria was detected for more than 500 and 150 days, respectively, in the two species.
K M, Johnson +3 more
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Machupo virus polypeptides: Identification by immunoprecipitation
Archives of Virology, 1985The most abundant protein in purified Machupo virions (Corvallo strain) labelled with 14C-Protein hydrolysate is a 64 K polypeptide which is associated with virion RNAs. Another structural polypeptide, 37 K, solubilized by nonionic detergent seems to be a major surface glycoprotein.
I S, Lukashevich, N N, Lemeshko
openaire +2 more sources
Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses [PDF]
Seven arenaviruses cause viral hemorrhagic fever in humans: the Old World arenaviruses Lassa and Lujo, and the New World Clade B arenaviruses Machupo (MACV), Junín (JUNV), Guanarito (GTOV), Sabiá (SABV), and Chapare (CHPV). All of these viruses are Risk Group 4 biosafety pathogens. MACV causes human disease outbreak with high case-fatality rates.
Jens H Kuhn +2 more
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