Results 161 to 170 of about 21,344 (285)

Cyclo-Polyproline: Chameleonic All-Peptide Macrocycles With Induced-Fit Host-Guest Recognition. [PDF]

Angew Chem Int Ed Engl
Girolamo CD, Fleming PC, Kwawu CR, Guimarães AR, Muldoon J, Bruno-Colmenarez J, Ortin Y, Probert MR, Fantuzzi F, Palma A.   +9 more
europepmc   +1 more source

Diarylethene‐Containing Photoswitchable Analogues of Tubulysins—Design, Synthesis, Biological, and Structural Evaluation

European Journal of Organic Chemistry, EarlyView.
Diarylethene‐containing cyclic tubulysin analogues were designed, synthesized, and evaluated as light‐responsive cytotoxic agents. One analogue showed reversible photoswitching, photoregulated tubulin polymerization inhibition, and photoform‐dependent cytotoxicity.
Anna Iampolska, Sergii Afonin, Oleg Babii, Mahri Park, Juan Estévez‐Gallego, Michel O. Steinmetz, Andrea E. Prota, Anne S. Ulrich, David R. Spring, Igor V. Komarov   +9 more
wiley   +1 more source

Massive barcode-free chemical screenings enable the discovery of bioactive macrocycles with passive membrane permeability. [PDF]

Nat Commun
Mata JM, Liu J, McKenna SM, van der Nol E, Havermans M, Delwel R, Filius M, Joo C, Vallaro M, Caron G, Pomplun SJ.   +10 more
europepmc   +1 more source

Truncation of Samroiyotmycin: Tailored seco‐Acids as Novel Antimalaria Compounds

European Journal of Organic Chemistry, EarlyView.
Six truncated samroiyotmycin‐derived antimalarials were synthesized by replacing the tosyloxazole unit with electron‐deficient aryl groups. The most active seco‐acid with EWG = 2 × CF3 outperformed the natural product SamA. Its enhanced activity supports a donor–acceptor interaction involving the electron‐poor aryl unit, consistent with inhibition of ...
Anton Czuczkowski, Anja Schäfer, Juliana A. Hüther, Bianca Wank, Robert Toews, Fotios Fotakis, Andreas Köhn, Markus Rehm, Matthias Rottmann, Anna Zens, Sabine Laschat   +10 more
wiley   +1 more source

Electronic transport in radial π-conjugated macrocyclic molecules: a density functional theory study. [PDF]

RSC Adv
Govindarajan S, Ramya K, Ravva MK, Mukhopadhyay S.   +3 more
europepmc   +1 more source

Chemoselective Aldehyde and Imine Reduction by a Macrocyclic Triazole–Borane Complex Triggered by a Non‐innocent Proton–Hydride Interaction

European Journal of Organic Chemistry, EarlyView.
This work describes the study on a new recyclable reagent, based on a macrocyclic triazole–borane complex. It showed high chemoselectivity for aldehyde reduction and reductive amination over ketones. This selectivity is driven by a noncovalent hydride–proton interaction that stabilizes the transition state for aldehydes but is sterically inhibited in ...
Luca Di Marino, Artur Brotons Rufes, Rosaria Schettini, Giorgio Della Sala, Francesco De Riccardis, Chiara Costabile, Irene Izzo   +6 more
wiley   +1 more source

Chirally locked and dynamic bis-perylene diimide macrocycles with multiple sources of chirality. [PDF]

Commun Chem
Hartmann D, Penty SE, Pal R, Barendt TA.
europepmc   +1 more source

Competing Charge Transport Pathways: A Spirobifluorene‐Based Molecular Loop

European Journal of Organic Chemistry, EarlyView.
A rigid molecular loop integrating a spirobifluorene (SBF) core with a cycloparaphenylene (CPP) moiety provides two distinct transport channels. Through‐space spiroconjugation and radial π‐conjugation along a CPP backbone coexist within a single molecule.
Brian Ogi, Riccardo Conte, Salome L. Heim, Herre S. J. van der Zant, Marcel Mayor   +4 more
wiley   +1 more source

Quinoline-Directed Folding in Anilide-Quinoline Hybrids: Length-Controlled Three-Dimensional Conformational Diversity. [PDF]

JACS Au
Xu W, Takeda A, Kumagai N.
europepmc   +1 more source

Protein‐Based High‐Performance Liquid Chromatography and Cyclodextrin‐Capillary Electrokinetic Chromatography for the Chiral Separation of Azoles

ELECTROPHORESIS, EarlyView.
Human serum albumin‐based high‐performance liquid chromatography and cyclodextrin‐based capillary electrokinetic chromatography were used for the chiral separation of azoles. Although only two of the five tested azoles could be enantioseparated by liquid chromatography, all of them were separated by capillary electrokinetic chromatography using single ...
Sarah Moreau, Amy Dillon, Giacomo Russo, Susanne K. Wiedmer   +3 more
wiley   +1 more source