Results 151 to 160 of about 1,793 (163)

Macrodomain protein from bacterium Streptomyces coelicolor

2014
Macrodomains are evolutionary conserved structural domains that bind ADP-ribose derivatives found in proteins with diverse cellular functions. Some proteins from the macrodomain family (human MacroD1, MacroD2) can hydrolyze ADP-ribosylated substrates and therefore reverse posttranslational modification - ADP-ribosylation in which an ADP-ribose moiety ...
Lalić, Jasna, Halasz, Mirna, Ćetković, Helena, Pleše, Bruna, Perina, Dragutin, Luić, Marija, Žaja, Roko, Sabljić, Igor, Mikoč, Andreja, Ahel, Ivan   +9 more
openaire   +1 more source

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

Journal of Biological Chemistry, 2021
Lilian C Russo, Sven T Sowa, Keith W Caldecott   +2 more
exaly  

Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain

ACS Medicinal Chemistry Letters, 2021
Martin Schröder, Vincent Olieric, VÍCTOR Hernández-Olmos   +2 more
exaly  

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 macrodomain of SARS-CoV-2

Proceedings of the National Academy of Sciences of the United States of America, 2023
Stefan Gahbauer, Matteo P Ferla, Yagmur U Doruk   +2 more
exaly  

Drug similarity and structure-based screening of medicinal compounds to target macrodomain-I from SARS-CoV-2 to rescue the host immune system: a molecular dynamics study

Journal of Biomolecular Structure and Dynamics, 2022
Mazhar Khan, Muhammad Suleman, Abdullah Shāh   +2 more
exaly  

The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase

Journal of Virology, 2021
Yousef M O Alhammad, David K Johnson, Guy G Poirier   +2 more
exaly  

ADP-ribose and analogues bound to the deMARylating macrodomain from the bat coronavirus HKU4

Proceedings of the National Academy of Sciences of the United States of America, 2021
Robert G Hammond, Norbert Schörmann, Robert Lyle Mcpherson   +2 more
exaly  

ADP-ribosyl–binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Proceedings of the National Academy of Sciences of the United States of America, 2018
Rachy Abraham, Robert Lyle Mcpherson, Åge Utt   +2 more
exaly  

Macrodomain-containing proteins: regulating new intracellular functions of mono(ADP-ribosyl)ation

Nature Reviews Molecular Cell Biology, 2013
Karla L H Feijs, Patricia Verheugd, Bernhard Lüscher   +2 more
exaly  

ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

Proceedings of the National Academy of Sciences of the United States of America, 2017
Robert Lyle Mcpherson, Rachy Abraham, Easwaran Sreekumar   +2 more
exaly