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Crystallographic Ensembles Reveal the Structural Basis of Binding Entropy in SARS-CoV2 Macrodomain
bioRxivStructure-based drug design has traditionally focused on optimizing static, enthalpic interactions between ligands and proteins or on displacing binding site solvent molecules to entropically favor binding.
Louella Seo +8 more
semanticscholar +1 more source
bioRxiv
Viral macrodomains are promising antiviral targets that counteract host ADP-ribosylation-mediated antiviral responses in mammals. However, their role in dual-host viruses within the mosquito vector is largely unknown.
Eugenia S. Bardossy +7 more
semanticscholar +1 more source
Viral macrodomains are promising antiviral targets that counteract host ADP-ribosylation-mediated antiviral responses in mammals. However, their role in dual-host viruses within the mosquito vector is largely unknown.
Eugenia S. Bardossy +7 more
semanticscholar +1 more source
Interactomics of SARS-CoV-2 Macrodomain 1 Reveals Putative Clients of ADP-ribosyl Hydrolase Activity
bioRxivSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has greatly impacted public health due to high rates of transmissibility and mutation during the COVID-19 pandemic.
Crissey D. Cameron +2 more
semanticscholar +1 more source
In silico analysis of the Chikungunya virus and SARS-CoV-2 Macrodomain
bioRxivThe macrodomain of the Chikungunya virus NSP3 protein (ChikV Mac1) hydrolyzes mono-ADP ribose post-translational modifications on the human host proteins. Mutations in Mac1 reduce ChikV virulence. Thus, ChikV Mac1 is a viral drug target.
Vikas Tiwari +4 more
semanticscholar +1 more source
Expanding the functional repertoire of macrodomains
Nature Structural & Molecular Biology, 2013Macrodomains are conserved globular domains that can interact with, and in some cases modify, ADP-ribose–based molecules. In this issue, two reports add to the functional repertoire of this domain, by demonstrating that a subset of macrodomain-containing proteins functions to catalyze the removal of protein-proximal ADP-ribose.
openaire +1 more source
bioRxiv
Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for months 1,2or even years. Millions of people have been infected with CHIKV, mostly in low and middle-income countries, and the virus continues to spread into
J. C. Aschenbrenner +17 more
semanticscholar +1 more source
Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for months 1,2or even years. Millions of people have been infected with CHIKV, mostly in low and middle-income countries, and the virus continues to spread into
J. C. Aschenbrenner +17 more
semanticscholar +1 more source
Polarized raman spectroscopy of oriented macrodomain of phospholipids containing amphotericin
Biochemical and Biophysical Research Communications, 1982Abstract A new method for preparing oriented macrodomains of phospholipid multilayers is described: it consists of controlled evaporation of solutions of phospholipid vesicles on specially prepared glass slides. The polarized Raman spectra, as well as the observation between crossed polarizers, show that the phospholipid molecules are oriented: the ...
M, Harrand, W L, Peticolas, R, Dupeyrat
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Macrodomain protein from bacterium Streptomyces coelicolor
2014Macrodomains are evolutionary conserved structural domains that bind ADP-ribose derivatives found in proteins with diverse cellular functions. Some proteins from the macrodomain family (human MacroD1, MacroD2) can hydrolyze ADP-ribosylated substrates and therefore reverse posttranslational modification - ADP-ribosylation in which an ADP-ribose moiety ...
Lalić, Jasna +9 more
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