Results 221 to 228 of about 4,884 (228)

ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence

Proceedings of the National Academy of Sciences of the United States of America, 2017
Robert Lyle McPherson, Rachy Abraham, Easwaran Sreekumar   +2 more
exaly  

ADP-ribosyl–binding and hydrolase activities of the alphavirus nsP3 macrodomain are critical for initiation of virus replication

Proceedings of the National Academy of Sciences of the United States of America, 2018
Rachy Abraham, Robert Lyle McPherson, Age Utt   +2 more
exaly  

STRUCTURAL BIOINFORMATICS OF HAEMOPHILUS INFLUENZAE MACRODOMAIN TER PROTEIN (MATP): IMPLICATIONS IN BIOCHEMISTRY, HEMATOLOGY AND DRUG DEVELOPMENT

Journal of Population Therapeutics & Clinical Pharmacology
Dr. Halima Sadi
semanticscholar   +1 more source

Analysis of Coronavirus Temperature-Sensitive Mutants Reveals an Interplay between the Macrodomain and Papain-Like Protease Impacting Replication and Pathogenesis

Journal of Virology, 2019
Xufang Deng, Robert C Mettelman, Amornrat O'brien   +2 more
exaly  

Discovery of dual thiobarbiturate-indole scaffold as a selective inhibitor targeting chikungunya virus nsP3 macrodomain through a cryptic binding pocket

bioRxiv
Men Thi Hoai Duong, Tommi Parviainen, Aditya Thiruvaiyaru, T. Ahola, Juha P. Heiskanen, L. Lehtiö   +5 more
semanticscholar   +1 more source

Hit-to-lead development of inhibitors of the Chikungunya virus nsP3 macrodomain using crystallographic fragment screening

Acta Crystallographica Section A: Foundations and Advances
J. C. Aschenbrenner, A. S. de Godoy, M. Fairhead, C. Tomlinson, B. Balcomb, P. Marples, M. Golding, G. Watt, M. Winokan, R. Lithgo, E. Capkin, K. Fieseler, A. Chandran, L. Koekemoer, X. Ni, C. Wild, Mary-Ann Xavier, X. Qiu, R. Xu, H. Almahli, R. Z. Saleem, W. Chen, M. H. Todd, W. Thompson, D. Fearon, F. von Delft   +25 more
semanticscholar   +1 more source

Cryo-EM of a Divergent Herpesvirus Reveals Structural Conservation and Novelty Including a Portal-Vertex Tegument Protein with Multiple Macrodomain-like Folds

bioRxiv
Amit Meir Ben Efraim, F. Petrov, M. McElwee, J. Streetley, Liisa Holm, Joe Grove, Andrew J. Davison, F. Rixon, D. Bhella   +8 more
semanticscholar   +1 more source

Synthesis and Biological Evaluation of Modified Peptide Derivatives Targeting the SARS-CoV-2 Nsp3 Macrodomain (Mac1) Replication Domain

ACS Omega
Ö. Özmen, Betul Orucoglu, Serap İpek Dingiş Birgül, Dilek Öztürk Civelek, Şeref Gül, A. Akdemir, Fatih Sönmez, Belma Zengin Kurt   +7 more
semanticscholar   +1 more source