Results 51 to 60 of about 43,807 (217)

AZITROMYCIN EFFICACY IN TREATMENT OF PEDIATRIC OUT-OF-HOSPITAL INFECTIONS

Вопросы современной педиатрии, 2012
Macrolides remain one of the most popular types of antibiotics prescribed in the outpatient’s clinic and also are second most popular after penicillins in the amount of consumption.
L. V. Kozlova
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

Relay Approach: A Convergent Synthesis of Key Fragments en route to (+)‐Neosorangicin A

Chemistry – A European Journal, EarlyView.
A selective synthesis of three key fragments of the antibiotically active (+)‐neosorangicin A is reported, providing a foundation for its convergent total synthesis and proof of strategy via a relay approach. ABSTRACT Herein, we report the synthesis of the three key fragments of the macrolide antibiotic (+)‐neosorangicin A, a compound exhibiting potent
Marvin Wenninger, Maxim Munt, Le Chang, Rositsa Stoykova, Roberto Ojcius, Oliver Spieß, Dieter Schinzer   +6 more
wiley   +1 more source

Distribution of erm genes and low prevalence of inducible resistance to clindamycin among staphylococci isolates

Brazilian Journal of Infectious Diseases
INTRODUCTION: Resistance to macrolides, lincosamides and streptogramins B (MLS B antibiotics) in staphylococci may be due to modification in ribosomal target methylase encoded by erm genes.
Vivian de Lima Spode Coutinho, Rodrigo Minuto Paiva, Keli Cristine Reiter, Fernanda de-Paris, Afonso Luis Barth, Alice Beatriz Mombach Pinheiro Machado   +5 more
doaj   +1 more source

Increase in Pneumococcus Macrolide Resistance, United States

Emerging Infectious Diseases, 2009
During year 6 (2005–2006) of the Prospective Resistant Organism Tracking and Epidemiology for the Ketolide Telithromycin surveillance study, 6,747 Streptococcus pneumoniae isolates were collected at 119 centers.
Stephen G. Jenkins, David J. Farrell
doaj   +1 more source

Regioselective Aldol Reactions Directed by Charge and Orbital Effects in Cyclic Germyl Dienolates: Synthesis of Three Distinct Regio‐ and Stereoisomers

Chemistry – A European Journal, EarlyView.
Charge and orbital control represent fundamental principles in organic chemistry. In this study, these principles are applied to the aldol reactions of a cyclic Ge‐dienolate. By systematically tuning the charge and orbital distributions of the Ge‐dienolates and their aldehyde reaction partners, regio‐ and stereoselective access to three distinct aldol ...
Taishi Nojima, Akihito Konishi, Makoto Yasuda   +2 more
wiley   +1 more source

Changes in macrolide resistance phenotype in pharyngeal group a streptococci isolates in children [PDF]

Medicinski Podmladak, 2018
Introduction: The second drugs of choice for treatment of pharyngitis caused by Streptococcus pyogenes (S.pyogenes; group A streptococcus - GAS) are macrolides.
Vuksanović Pavle, Opavski Nataša
doaj  

In vitro activity of macrolides against Streptococcus pneumoniae and Streptococcus pyogenes in the Russian Federation: “Status praesens” [PDF]

Клиническая микробиология и антимикробная химиотерапия
Objective. To evaluate in vitro activity of various macrolide antibiotics against a current collection of clinical isolates of Streptococcus pneumoniae and Streptococcus pyogenes isolated from patients with community-acquired infections in different ...
Kozlov R.S., Ivanchik N.V., Mikotina A.V., Dekhnich A.V.   +3 more
doaj   +1 more source

Retro‐Hetero‐Michael Addition Strategies in Organic Synthesis

European Journal of Organic Chemistry, EarlyView.
In this review, synthetic approaches to carbo‐ and heterocyclic compounds, including natural products, published in the last 15 years (2011–2025) which have either relied upon or included a retro‐hetero‐Michael addition step at any stage are discussed.
Dina Scarpi, Ernesto G. Occhiato
wiley   +1 more source