Results 31 to 40 of about 54,415 (288)

Macrolides and their role in the treatment of community-acquired pneumonia of various etiology

Медицинский совет, 2015
The success of antibiotic therapy depends on the correct choice of antibiotic, timely administration, conditions of the host (patient) and microorganism (bacterial pathogen resistance to a drug), bioavailability and bioequivalence.
I. V. Leschenko, Z. D. Bobyleva
doaj   +1 more source

Eco‐Geography Reverses Dominant AMR Reservoirs in Klebsiella pneumoniae: Integron‐Rich Mobilomes and Cross‐Niche Connectivity

Advanced Science, EarlyView.
Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin, Biao Tang, Hao Xu, Jiajie Qian, Feifan Shi, Junhui Zhao, Xiaorui Mao, Xiaohe Hu, Ruishan Liu, Wenhong Liu, Xiawei Jiang, Beiwen Zheng, Guoping Zhao   +12 more
wiley   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Impact of macrolide antibiotics on gut microbiota diversity with age-specific implications and scientific insights

Medicine in Microecology
This review investigates the effects of macrolides on the gut microbiota across different age groups. Macrolides, widely used to treat various infections, have been shown to disrupt the gut microbiome, leading to reduced bacterial diversity and increased
H. Shayista, M.N. Nagendra Prasad, S. Niranjan Raj, Ashwini Prasad, S. Satish, H.K. Ranjini, K. Manju, Ravikumara, Raghuraj Singh Chouhan, Olga Y. Khohlova, Olga V. Perianova, S. Lakshmi, Syed Baker   +12 more
doaj   +1 more source

New Bicyclic Azalide Macrolides Obtained by Tandem Palladium Catalyzed Allylic Alkylation/Conjugated Addition Reaction

Molecules, 2022
Unprecedented tandem allylic alkylation/intermolecular Michael addition was used in the preparation of novel bicyclic azalides. NMR spectroscopy was used not only to unambiguously determine and characterize the structures of these unexpected products of ...
Sulejman Alihodžić, Hana Čipčić Paljetak, Ana Čikoš, Ivaylo Jivkov Elenkov   +3 more
doaj   +1 more source

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source

Respiratory mycoplasmosis in pediatrician's practice

Медицинский совет, 2016
Respiratory mycoplasmosis is a group of infectious and inflammatory diseases of the respiratory system caused by pathogenic microorganisms - Mycoplasma species. It was found that the major causative agent is Mycoplasma pneumoniae (M. pneumoniae).
A. L. Zaplatnikov, I. D. Maikova, I. V. Lepiseva   +2 more
doaj   +1 more source

Macrolide Resistance in Bordetella pertussis: Current Situation and Future Challenges

Antibiotics, 2022
Pertussis is a highly contagious respiratory infection caused by Bordetella pertussis bacterium. The mainstay of treatment is macrolide antibiotics that reduce transmissibility, shorten the duration of symptoms and decrease mortality in infants. Recently,
Lauri Ivaska, Alex-Mikael Barkoff, Jussi Mertsola, Qiushui He   +3 more
doaj   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Comparative efficacy and safety of clarithromycin in the treatment of bacterial sinusitis

Медицинский совет, 2014
Inflammatory pathology of the nasal cavity and paranasal sinuses is one of the major challenges in otorhinolaryngology today. Among patients hospitalized in ENT units, the incidence of inflammatory diseases of the paranasal sinuses is up to 36%.
V. I. Popadyuk, A. I. Chernolev, I. A. Korshunova   +2 more
doaj   +1 more source