Results 41 to 50 of about 75,798 (257)
Macrolides and their role in the treatment of community-acquired pneumonia of various etiology
Медицинский совет, 2015 The success of antibiotic therapy depends on the correct choice of antibiotic, timely administration, conditions of the host (patient) and microorganism (bacterial pathogen resistance to a drug), bioavailability and bioequivalence.
I. V. Leschenko, Z. D. Bobyleva
doaj +1 more source
Multi‐Targeting Non‐Specific Genome Engineering in Bacteria
Advanced Science, EarlyView.In this study, we provide the first case to use the multi‐targeting integrase (MTI) systems in bacteria and develop a host‐independent generalizable approach, MNGE (Multi‐targeting Non‐specific Genome Engineering), for multi‐copy and random integration of metabolic genes or pathways in both Gram‐positive and Gram‐negative bacteria, which will ...
Runze Sun +7 more
wiley +1 more source
A Genomic Catalog of Migratory Microbiomes from Wild Birds across China's Habitats
Advanced Science, EarlyView.ABSTRACT Migratory birds play an important role in the spread of antimicrobial resistance (AMR); however, gaps in surveillance data from vital regions along migratory flyways across China limit the detection of emergent threats. Here, we assembled 340 metagenomes from 52 bird species covering 11 provincial administrative districts in China, presenting ...
Yanan Wang +13 more
wiley +1 more source
Medicine in MicroecologyThis review investigates the effects of macrolides on the gut microbiota across different age groups. Macrolides, widely used to treat various infections, have been shown to disrupt the gut microbiome, leading to reduced bacterial diversity and increased
H. Shayista +12 more
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Molecules, 2022 Unprecedented tandem allylic alkylation/intermolecular Michael addition was used in the preparation of novel bicyclic azalides. NMR spectroscopy was used not only to unambiguously determine and characterize the structures of these unexpected products of ...
Sulejman Alihodžić +3 more
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Natural product diversity of actinobacteria in the Atacama Desert [PDF]
, 2018 Natural Product diversityPeer reviewedPublisher ...
Ebel, Rainer +2 more
core +3 more sources
Animal Research and One Health, EarlyView.Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali +10 more
wiley +1 more source
Respiratory mycoplasmosis in pediatrician's practice
Медицинский совет, 2016 Respiratory mycoplasmosis is a group of infectious and inflammatory diseases of the respiratory system caused by pathogenic microorganisms - Mycoplasma species. It was found that the major causative agent is Mycoplasma pneumoniae (M. pneumoniae).
A. L. Zaplatnikov +2 more
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Macrolide Resistance in Bordetella pertussis: Current Situation and Future Challenges
Antibiotics, 2022 Pertussis is a highly contagious respiratory infection caused by Bordetella pertussis bacterium. The mainstay of treatment is macrolide antibiotics that reduce transmissibility, shorten the duration of symptoms and decrease mortality in infants. Recently,
Lauri Ivaska +3 more
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Macrolide and macrolide-related antibacterial agents
Folia Pharmacologica Japonica, 2007 マクロライド系抗菌薬は，グラム陽性菌および非定型病原体に対する抗菌力が強く，呼吸器疾患の治療薬として汎用されてきた．我が国では，14員環，15員環および16員環マクロライド系およびケトライド系抗菌薬が上市している．エリスロマイシンの欠点を克服するための創薬研究から，ニューマクロライドと呼ばれるマクロライド系抗菌薬のロキシスロマイシン，クラリスロマイシンおよびアジスロマイシンが半合成された．その後，耐性肺炎球菌に対する抗菌活性が増強された，ケトライド系抗菌薬のテリスロマイシンが半合成された．本稿では主として，14，15員環マクロライド系およびケトライド系を中心とした抗菌薬の創薬・開発研究の歴史ならびに抗菌作用の特徴を概説した．
openaire +3 more sources