Results 41 to 50 of about 55,784 (291)
Intracellular bioactivity of macrolides [PDF]
, 1996 A brief overview is provided of the bioactivity of macrolides against a range of bacterial species. Topics considered include the cellular pharmacokinetics of uptake and efflux of these drugs and the importance of intra- or extracellular and cytoplasmic ...
Labro, Marie Thérèse +1 more
core +1 more source
Current Opinion in Microbiology, 2008 In spite of decades of research, our knowledge of the mode of interaction of macrolide antibiotics with their ribosomal target and of the mechanism of action of these drugs remain fragmentary. Experimental facts obtained over the past several years question some of the concepts that were viewed as a 'common knowledge'.
openaire +2 more sources
Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae
Advanced Science, EarlyView.Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch +6 more
wiley +1 more source
Molecules, 2022 Unprecedented tandem allylic alkylation/intermolecular Michael addition was used in the preparation of novel bicyclic azalides. NMR spectroscopy was used not only to unambiguously determine and characterize the structures of these unexpected products of ...
Sulejman Alihodžić +3 more
doaj +1 more source
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Chronic rhinosinusitis (CRS) represents a spectrum of inflammatory endotypes, driven by distinct T helper (Th) immune responses. The high rate of recurrent disease despite appropriate medical and surgical interventions highlights the need for improved characterization beyond the traditional type 2 and non‐type 2 phenotypes to better
Liyona Kampel +9 more
wiley +1 more source
Medicine in MicroecologyThis review investigates the effects of macrolides on the gut microbiota across different age groups. Macrolides, widely used to treat various infections, have been shown to disrupt the gut microbiome, leading to reduced bacterial diversity and increased
H. Shayista +12 more
doaj +1 more source
Respiratory mycoplasmosis in pediatrician's practice
Медицинский совет, 2016 Respiratory mycoplasmosis is a group of infectious and inflammatory diseases of the respiratory system caused by pathogenic microorganisms - Mycoplasma species. It was found that the major causative agent is Mycoplasma pneumoniae (M. pneumoniae).
A. L. Zaplatnikov +2 more
doaj +1 more source
Macrolide Resistance in Bordetella pertussis: Current Situation and Future Challenges
Antibiotics, 2022 Pertussis is a highly contagious respiratory infection caused by Bordetella pertussis bacterium. The mainstay of treatment is macrolide antibiotics that reduce transmissibility, shorten the duration of symptoms and decrease mortality in infants. Recently,
Lauri Ivaska +3 more
doaj +1 more source
Macrolide and macrolide-related antibacterial agents
Folia Pharmacologica Japonica, 2007 マクロライド系抗菌薬は，グラム陽性菌および非定型病原体に対する抗菌力が強く，呼吸器疾患の治療薬として汎用されてきた．我が国では，14員環，15員環および16員環マクロライド系およびケトライド系抗菌薬が上市している．エリスロマイシンの欠点を克服するための創薬研究から，ニューマクロライドと呼ばれるマクロライド系抗菌薬のロキシスロマイシン，クラリスロマイシンおよびアジスロマイシンが半合成された．その後，耐性肺炎球菌に対する抗菌活性が増強された，ケトライド系抗菌薬のテリスロマイシンが半合成された．本稿では主として，14，15員環マクロライド系およびケトライド系を中心とした抗菌薬の創薬・開発研究の歴史ならびに抗菌作用の特徴を概説した．
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, 2005 Three randomized control trials have recently been published which have studied the effect of the macrolide antibiotic, azithromycin, in patients with cystic fibrosis (CF).1 3 This review examines the history of macrolide development, antimicrobial ...
Senini, S. L. +2 more
core +1 more source