Results 91 to 100 of about 16,667 (258)

The macroscopic effects of microscopic heterogeneity

, 2012
Over the past decade, advances in super-resolution microscopy and particle-based modeling have driven an intense interest in investigating spatial heterogeneity at the level of single molecules in cells.
Aleksic, Andrews, Andrews, Aoki, Asakura, Bancaud, Banks, Berg, Betzig, Bray, Bray, Burack, Bénichou, Chevalier, Dard, Duke, Eggeling, Ellis, Ferrell, Ferrell, Gerland, Golding, Gopalakrishnan, Govern, Gowers, Grecco, Gurry, Hancock, Hattne, Hell, Howard, Hu, Huang, Kalay, Kholodenko, Kinkhabwala, Kolch, Koshland, Kusumi, Kusumi, Kusumi, Lagerholm, Li, Lingwood, Lis, Locasale, Lomholt, Lommerse, Lutkenhaus, Machta, Markevich, Mello, Miller, Monod, Morelli, Mugler, Murakoshi, Muramatsu, Nash, Oh, Pike, Plimpton, Plowman, Prior, Redner, Rust, Sauro, Simons, Sourjik, Sourjik, Stanford, Takahashi, Tian, Tkačik, Valitutti, van Albada, van Zon, van Zon, Wartlick, Weiss, Wofsy, Zhao, Zimmerman, Zimmerman   +83 more
core   +1 more source

Macromolecular crowding effects in crowded biomolecular environments

, 2018
In dieser Arbeit werden Computer-Simulationen eingesetzt um den Einfluss biologisch relevanter, konzentrierter Umgebungen auf das strukturelle Gleichgewicht von (Bio-)Polymeren zu untersuchen. Für diese Simulationen wird ein zuvor beschriebener Monte Carlo Algorithmus verwendet, welcher die Flexibilität der Moleküle anhand von strukturellen Ensembles ...
openaire   +3 more sources

Dilute but Dense – Reversible Crosslinking Enables Water‐Rich (Bio)polymer Condensates

Advanced Science, EarlyView.
Reversible crosslinking between two types of (bio)polymers drives liquid–liquid phase separation even in good solvent. The arrangement of binding motifs controls condensate formation and density, and internal network structure. Simulations and theory reveal a closed‐loop coexistence phase diagram at very low monomer concentrations and re‐entrant ...
Xinxiang Chen, Jude Ann Vishnu, Pol Besenius, Julian König, Friederike Schmid   +4 more
wiley   +1 more source

Crowding-facilitated macromolecular transport in attractive micropost arrays

Scientific Reports, 2017
Our study of DNA dynamics in weakly attractive nanofabricated post arrays revealed crowding enhances polymer transport, contrary to hindered transport in repulsive medium.
Fan-Tso Chien, Po-Keng Lin, Wei Chien, Cheng-Hsiang Hung, Ming-Hung Yu, Chia-Fu Chou, Yeng-Long Chen   +6 more
doaj   +1 more source

Antibody binding reports spatial heterogeneities in cell membrane organization

Nature Communications, 2023
The spatial organization of cell membrane glycoproteins and glycolipids is critical for mediating the binding of ligands, receptors, and macromolecules on the plasma membrane.
Daniel P. Arnold, Yaxin Xu, Sho C. Takatori   +2 more
doaj   +1 more source

Anomalous transport in the crowded world of biological cells

, 2013
A ubiquitous observation in cell biology is that diffusion of macromolecules and organelles is anomalous, and a description simply based on the conventional diffusion equation with diffusion constants measured in dilute solution fails.
Franosch, Thomas, Höfling, Felix
core   +1 more source

Atomistic Simulations of Macromolecular Crowding [PDF]

Biophysical Journal, 2010
Protein folding, binding, and aggregation are known to be affected by macromolecular crowding [1], which is an integral part of intracellular environments. Realistic modeling of intracellular crowding requires computer simulations. In direct simulations of test proteins mixed with crowders, it has only been practical to represent the proteins at a ...
openaire   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

Liquid–Liquid Phase Separation in the Presence of Macromolecular Crowding and State-dependent Kinetics [PDF]

, 2021
Alick-O. Vweza, Chul-Gyu Song, Kil To Chong   +2 more
openalex   +1 more source

Studying Macromolecular Composition in Cell–Cell Interfaces Using 3D Membrane Reconstitution Systems

Advanced Science, EarlyView.
A comprehensive understanding of the interactions between proteins, lipids and glycocalyx components at the immune synapse is still lacking. Here, an artificial and a semi‐artificial model contact system were established to reconstitute the cell‐cell contact in 3D. The model systems enable the examination of macromolecule enrichment or depletion at the
Franziska Ragaller, Amelie Maribel Schneider, Ellen Sjule, Renhua Sun, Xiao Han, Luca Andronico, Edward Jenkins, Michael Dustin, Adnane Achour, Erdinc Sezgin   +9 more
wiley   +1 more source