Results 81 to 90 of about 6,829 (247)

Macromolecular crowding effects in crowded biomolecular environments

, 2018
In dieser Arbeit werden Computer-Simulationen eingesetzt um den Einfluss biologisch relevanter, konzentrierter Umgebungen auf das strukturelle Gleichgewicht von (Bio-)Polymeren zu untersuchen. Für diese Simulationen wird ein zuvor beschriebener Monte Carlo Algorithmus verwendet, welcher die Flexibilität der Moleküle anhand von strukturellen Ensembles ...
openaire   +3 more sources

Macromolecular Crowding as a Cell VolumeSensor

Cellular Physiology and Biochemistry, 2000
The non-ideal properties of solutions containing high concentrations of macromolecules can result in enormous increases in the activity of the individual macromolecules. There is considerable evidence that macromolecular crowding and confinement not only occur in cells, but that these are major determinants of the activity of the proteins and other ...
openaire   +2 more sources

Protein Diffusion and Macromolecular Crowding [PDF]

Biophysical Journal, 2010
Having recently quantified how crowding can affect equilibrium protein stability (1), we have turned our attention to diffusion. Our test molecule is the small globular protein, chymotrypsin inhibitor 2. Our crowding molecules are both the synthetic polymer polyvinylpyrrolidone (PVP) and several globular proteins.
Pielak, Gary, Wang, Yaqiang, Li, Conggang   +2 more
openaire   +1 more source

Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome [PDF]

, 2021
A. Hempelmann, Laura Hartleb, Monique van Straaten, Hamidreza Hashemi, Johan Zeelen, Kevin Bongers, F. Nina Papavasiliou, Markus Engstler, C. Erec Stebbins, Nicola G. Jones   +9 more
openalex   +3 more sources

Protein Stability and Macromolecular Crowding [PDF]

Biophysical Journal, 2012
The environment inside cells is vastly different from the dilute, idealized conditions used in nearly all biophysical studies. Cells are exceptionally complex and contain macromolecules at concentrations exceeding 300 g/L. There are at least two profound consequences of the cellular environment that impact globular proteins.
Sarkar, Mohona, Monteith, William B., Wang, Yaqiang, Pielak, Gary J.   +3 more
openaire   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Making microenvironments: A look into incorporating macromolecular crowding into in vitro experiments, to generate biomimetic microenvironments which are capable of directing cell function for tissue engineering applications

Journal of Tissue Engineering, 2017
Biomimetic microenvironments are key components to successful cell culture and tissue engineering in vitro. One of the most accurate biomimetic microenvironments is that made by the cells themselves. Cell-made microenvironments are most similar to the in
Paula Benny, Michael Raghunath
doaj   +1 more source

From brush conformation to 3D Supraparticles: Programmable self‐assembly of polymer‐grafted nanoparticles in emulsion confinement

Bulletin of the Korean Chemical Society, EarlyView.
This review highlights how the conformational adaptability of polymer‐grafted nanoparticles drives their programmable self‐assembly within 3D emulsion droplets. By coupling brush thermodynamics with soft confinement, these dynamic building blocks form hierarchical supraparticles tailored for advanced plasmonics, compartmentalized catalysis, and stimuli‐
Hongseok Yun
wiley   +1 more source

Multifunctional Design of Solid Polymer Electrolytes: Paving the Way for High‐Performance All‐Solid‐State Batteries

Carbon Energy, EarlyView.
This review provides a comprehensive and systematic overview of the multifunctional design strategies for solid polymer electrolytes (SPEs), a pivotal component for enabling high‐performance all‐solid‐state batteries (ASSBs). It begins with a detailed classification of SPE systems and elaborates on their respective molecular design principles. The work
Bin Man, Yuzhen Zhao, Bo Fu, Yulong Zeng, Yinwen Chen, Qingrui Liu, Wenjing Luo, Xin Li, Xuewei Li, Zikang Zhang, Yun Zheng, Sijie Liu   +11 more
wiley   +1 more source

Organelle‐Resolved Tetrazine‐trans‐Cyclooctene Click Chemistry for Cargo Delivery and Release

Chemistry – A European Journal, EarlyView.
Bioorthogonal click chemistry tools provide a means for specific intracellular conjugation of molecules. In this study, we used reactive tetrazine (Tz) and TCO moieties for labeling of organelles and organelle‐specific delivery and activation of doxorubicin prodrugs.
Oleh Durydivka, Marek Chovanec, Rastislav Dzijak, Michal Rahm, Jachym Hrusak, Paul E. Reyes‐Gutierrez, Milan Vrabel   +6 more
wiley   +1 more source