Results 71 to 80 of about 228,358 (272)
Macromolecular Crowding as a Regulator of Gene Transcription [PDF]
Biophysical Journal, 2014 Studies of macromolecular crowding have shown its important effects on molecular transport and interactions in living cells. Less clear is the effect of crowding when its influence is incorporated into a complex network of interactions. Here, we explore the effects of crowding in the cell nucleus on a model of gene transcription as a network of ...
Matsuda, Hiroaki +3 more
openaire +2 more sources
Macromolecular crowding induces holo α-lactalbumin aggregation by converting to its apo form.
PLoS ONE, 2014 Macromolecular crowding has been shown to have an exacerbating effect on the aggregation propensity of amyloidogenic proteins; while having an inhibitory effect on the non-amyloidogenic proteins.
Shruti Mittal +1 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Regulation of Actin Bundle Mechanics and Structure by Intracellular Environmental Factors
Frontiers in Physics, 2021 The mechanical and structural properties of actin cytoskeleton drive various cellular processes, including structural support of the plasma membrane and cellular motility.
Nicholas Castaneda +6 more
doaj +1 more source
Cell wall damage increases macromolecular crowding effects in the Escherichia coli cytoplasm
bioRxiv, 2022 The intracellular milieu is crowded with biomacromolecules. Macromolecular crowding changes the interactions, diffusion, and conformations of the biomacromolecules.
Theodoros Pittas, Weiyan Zuo, A. Boersma
semanticscholar +1 more source
CaMKII binding to GluN2B is differentially affected by macromolecular crowding reagents.
PLoS ONE, 2014 Binding of the Ca2+/calmodulin(CaM)-dependent protein kinase II (CaMKII) to the NMDA-type glutamate receptor (NMDAR) subunit GluN2B controls long-term potentiation (LTP), a form of synaptic plasticity thought to underlie learning and memory.
Dayton J Goodell +3 more
doaj +1 more source
Biomaterials, 2022 Although cell-derived matrices are at the forefront of scientific research and technological innovation for the development of in vitro tumour models, their two-dimensional structure and low extracellular matrix composition restrict their capacity to ...
N. Shologu +4 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Enzyme activity in the crowded milieu.
PLoS ONE, 2012 The cytosol of a cell is a concentrated milieu of a variety of different molecules, including small molecules (salts and metabolites) and macromolecules such as nucleic acids, polysaccharides, proteins and large macromolecular complexes.
Tobias Vöpel, George I Makhatadze
doaj +1 more source
A didactic model of macromolecular crowding effects on protein folding. [PDF]
PLoS ONE, 2010 A didactic model is presented to illustrate how the effect of macromolecular crowding on protein folding and association is modeled using current analytical theory and discrete molecular dynamics.
Douglas Tsao +2 more
doaj +1 more source