Results 61 to 70 of about 103,280 (234)
Macromolecular Crowding as a Regulator of Gene Transcription [PDF]
Biophysical Journal, 2014 Studies of macromolecular crowding have shown its important effects on molecular transport and interactions in living cells. Less clear is the effect of crowding when its influence is incorporated into a complex network of interactions. Here, we explore the effects of crowding in the cell nucleus on a model of gene transcription as a network of ...
Matsuda, Hiroaki +3 more
openaire +2 more sources
Enzyme activity in the crowded milieu.
PLoS ONE, 2012 The cytosol of a cell is a concentrated milieu of a variety of different molecules, including small molecules (salts and metabolites) and macromolecules such as nucleic acids, polysaccharides, proteins and large macromolecular complexes.
Tobias Vöpel, George I Makhatadze
doaj +1 more source
Progress on Crowding Effect in Cell-like Structures
Membranes, 2022 Several biological macromolecules, such as proteins, nucleic acids, and polysaccharides, occupy about 30% of the space in cells, resulting in a crowded macromolecule environment.
Chao Li +3 more
doaj +1 more source
Advanced Materials, EarlyView.Cancer‐associated NPC remodeling creates a high‐flux, low‐stringency nuclear state that supports malignant adaptation but increases mechanical fragility. Targeting the FG‐barrier or NPC scaffold may drive mechanostat failure, envelope rupture, DNA damage, and loss of nuclear integrity.
Sílvio Terra Stefanello +5 more
wiley +1 more source
Scientific Reports, 2017 The cellular milieu is a complex and crowded aqueous solution. Macromolecular crowding effects are commonly studied in vitro using crowding agents. The aim of the present study was to evaluate the effects, if any, of macromolecular synthetic crowding ...
Mariane Rotta +6 more
doaj +1 more source
All‐Amyloid Functional Coacervates
Advanced Materials, EarlyView.This study introduces an all‐amyloid interfacial complex coacervate technique that employs charge‐mediated or functionalization‐assisted complexation of oppositely charged food protein‐derived amyloid nanofibrils to engineer functional soft constructs across multiple length scales.
Seyyed Alireza Hashemi +4 more
wiley +1 more source
A didactic model of macromolecular crowding effects on protein folding. [PDF]
PLoS ONE, 2010 A didactic model is presented to illustrate how the effect of macromolecular crowding on protein folding and association is modeled using current analytical theory and discrete molecular dynamics.
Douglas Tsao +2 more
doaj +1 more source
Culinary Chemistry as a Platform for Interfacial Materials Design
Advanced Materials Interfaces, EarlyView.Culinary processes control interfaces through heating, shear, gelation, and molecular transport. This Review connects selected gastronomic examples with food‐derived nanomaterials, plasmonic sensing, anthocyanin photovoltaics, and intelligent packaging. Original agar‐based plasmonic films illustrate the proposed translation.
Josep Moreno +12 more
wiley +1 more source
Macromolecular crowding effects on globular protein stability [PDF]
, 2011 Macromolecular crowding inside cells is proposed to change many aspects of proteins compared to dilute solution. As such, it is an increasingly studied topic, both theoretically and experimentally.
Miklos, Andrew C.
core +1 more source
The 2D Structure of the T. brucei Preedited RPS12 mRNA Is Not Affected by Macromolecular Crowding
Journal of Nucleic Acids, 2017 Mitochondrial transcript maturation in African trypanosomes requires RNA editing to convert sequence-deficient pre-mRNAs into translatable mRNAs. The different pre-mRNAs have been shown to adopt highly stable 2D folds; however, it is not known whether ...
W.-Matthias Leeder +2 more
doaj +1 more source