Results 61 to 70 of about 6,829 (247)

Progress on Crowding Effect in Cell-like Structures

Membranes, 2022
Several biological macromolecules, such as proteins, nucleic acids, and polysaccharides, occupy about 30% of the space in cells, resulting in a crowded macromolecule environment.
Chao Li, Xiangxiang Zhang, Mingdong Dong, Xiaojun Han   +3 more
doaj   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

The 2D Structure of the T. brucei Preedited RPS12 mRNA Is Not Affected by Macromolecular Crowding

Journal of Nucleic Acids, 2017
Mitochondrial transcript maturation in African trypanosomes requires RNA editing to convert sequence-deficient pre-mRNAs into translatable mRNAs. The different pre-mRNAs have been shown to adopt highly stable 2D folds; however, it is not known whether ...
W.-Matthias Leeder, Stephan Voskuhl, H. Ulrich Göringer   +2 more
doaj   +1 more source

Large-scale analysis of macromolecular crowding effects on protein aggregation using a reconstituted cell-free translation system

Frontiers in Microbiology, 2015
Proteins must fold into their native structures in the crowded cellular environment, to perform their functions. Although such macromolecular crowding has been considered to affect the folding properties of proteins, large-scale experimental data have so
Tatsuya eNiwa, Ryota eSugimoto, Lisa eWatanabe, Shugo eNakamura, Takuya eUeda, Hideki eTaguchi   +5 more
doaj   +1 more source

Macromolecular crowding as a suppressor of human IAPP fibril formation and cytotoxicity. [PDF]

PLoS ONE, 2013
The biological cell is known to exhibit a highly crowded milieu, which significantly influences protein aggregation and association processes. As several cell degenerative diseases are related to the self-association and fibrillation of amyloidogenic ...
Janine Seeliger, Alexander Werkmüller, Roland Winter   +2 more
doaj   +1 more source

Stable Protein‐Based G‐Quadruplex‐Derived Supramolecular Bioinks as Tunable ECM‐Mimetic Constructs Assembled by Combining Non‐Covalent and Covalent Strategies

Advanced Materials, EarlyView.
Harnessing the synergistic interplay of supramolecular self‐assembly, under macromolecular crowding conditions, and enzymatic‐mediated covalent crosslinking toward a stable protein‐based G‐quadruplex‐derived supramolecular bioink. This bioinspired strategy enables the biofabrication of complex and tunable ECM‐mimetic constructs, providing a platform ...
Vera Sousa, Rita Sobreiro‐Almeida, Bart W. L. van den Bersselaar, E. W. Meijer, Ghislaine Vantomme, João Borges, João F. Mano   +6 more
wiley   +1 more source

Liquid–Liquid Phase Separation in the Presence of Macromolecular Crowding and State-dependent Kinetics [PDF]

, 2021
Alick-O. Vweza, Chul-Gyu Song, Kil To Chong   +2 more
openalex   +1 more source

Self‐Seeded Nucleation of PET in a Benign Solvent Yields a High Modulus Aerogel With Ultra‐Low Thermal Conductivity

Advanced Materials, EarlyView.
A new benign solvent (1,3‐diphenylacetone) enables a simple, safe, and sustainable dissolution and gelation method to convert waste PET into low density, monolithic aerogels with high mechanical strength (E = 20 MPa) and remarkably low thermal conductivity (k = 21.9 to 28.9 mW/m·K).
Kira R. Baugh, Garrett F. Godshall, Glenn A. Spiering, Isabela Trindade Coutinho, Alejandro A. Rodriguez, Katherine J. Wood, Aiyana Gonzalez‐Arellano, Sadeq Malakooti, Stephanie L. Vivod, Robert B. Moore   +9 more
wiley   +1 more source

How does domain replacement affect fibril formation of the rabbit/human prion proteins. [PDF]

PLoS ONE, 2014
It is known that in vivo human prion protein (PrP) have the tendency to form fibril deposits and are associated with infectious fatal prion diseases, while the rabbit PrP does not readily form fibrils and is unlikely to cause prion diseases.
Xu Yan, Jun-Jie Huang, Zheng Zhou, Jie Chen, Yi Liang   +4 more
doaj   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source