Results 41 to 50 of about 228,358 (272)

Hyaluronic Acid as Macromolecular Crowder in Equine Adipose-Derived Stem Cell Cultures

Cells, 2021
The use of macromolecular crowding in the development of extracellular matrix-rich cell-assembled tissue equivalents is continuously gaining pace in regenerative engineering.
Sergio Garnica-Galvez, Stefanie H. Korntner, Ioannis Skoufos, Athina Tzora, Nikolaos Diakakis, Nikitas Prassinos, Dimitrios I. Zeugolis   +6 more
doaj   +1 more source

Carrageenan as a macromolecular crowding agent in human umbilical cord derived mesenchymal stromal cell culture.

International Journal of Biological Macromolecules, 2023
Cell sheet tissue engineering requires prolonged in vitro culture for the development of implantable devices. Unfortunately, lengthy in vitro culture is associated with cell phenotype loss and substantially higher cost of goods, which collectively hinder
Shanshan Du, S. Elliman, D. Zeugolis, T. O’Brien   +3 more
semanticscholar   +1 more source

The Role of Crowding Forces in Juxtaposing β-Globin Gene Domain Remote Regulatory Elements in Mouse Erythroid Cells. [PDF]

PLoS ONE, 2015
The extremely high concentration of macromolecules in a eukaryotic cell nucleus indicates that the nucleoplasm is a crowded macromolecular solution in which large objects tend to gather together due to crowding forces.
Arkadiy K Golov, Alexey A Gavrilov, Sergey V Razin   +2 more
doaj   +1 more source

Effects of Macromolecular Crowding on Genetic Networks [PDF]

Biophysical Journal, 2011
The intracellular environment is crowded with proteins, DNA, and other macromolecules. Under physiological conditions, macromolecular crowding can alter both molecular diffusion and the equilibria of bimolecular reactions and therefore is likely to have a significant effect on the function of biochemical networks.
M.J. Morelli, R.J. Allen, P.R. ten Wolde (Pieter Rein)   +2 more
openaire   +2 more sources

Macromolecular crowding-based biofabrication utilizing unmodified extracellular matrix bioinks. [PDF]

Acta Biomater
Jordan SN, Li X, Rossello-Martinez A, Liang Z, Gong X, Xiao H, Mak M.   +6 more
europepmc   +3 more sources

A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast

eLife, 2020
Cellular aging is a multifactorial process that is characterized by a decline in homeostatic capacity, best described at the molecular level. Physicochemical properties such as pH and macromolecular crowding are essential to all molecular processes in ...
Sara N Mouton, David J Thaller, Matthew M Crane, Irina L Rempel, Owen T Terpstra, Anton Steen, Matt Kaeberlein, C Patrick Lusk, Arnold J Boersma, Liesbeth M Veenhoff   +9 more
doaj   +1 more source

The contrasting effect of macromolecular crowding on amyloid fibril formation. [PDF]

PLoS ONE, 2012
Amyloid fibrils associated with neurodegenerative diseases can be considered biologically relevant failures of cellular quality control mechanisms.
Qian Ma, Jun-Bao Fan, Zheng Zhou, Bing-Rui Zhou, Sheng-Rong Meng, Ji-Ying Hu, Jie Chen, Yi Liang   +7 more
doaj   +1 more source

Adapting the Scar-in-a-Jar to Skin Fibrosis and Screening Traditional and Contemporary Anti-Fibrotic Therapies

Frontiers in Bioengineering and Biotechnology, 2021
Skin fibrosis still constitutes an unmet clinical need. Although pharmacological strategies are at the forefront of scientific and technological research and innovation, their clinical translation is hindered by the poor predictive capacity of the ...
João Q. Coentro, Ulrike May, Stuart Prince, John Zwaagstra, Olli Ritvos, Tero A.H. Järvinen, Tero A.H. Järvinen, Dimitrios I. Zeugolis, Dimitrios I. Zeugolis   +8 more
doaj   +1 more source

Impact of macromolecular crowding on DNA replication [PDF]

Nature Communications, 2013
Enzymatic activities in vivo occur in a crowded environment composed of many macromolecules. This environment influences DNA replication by increasing the concentration of the constituents, desolvation, decreasing the degrees of freedom for diffusion and hopping of proteins onto DNA, and enhancing binding equilibria and catalysis.
Akabayov, Barak, Akabayov, Sabine R., Wagner, Gerhard, Richardson, Charles, Lee, Seung–Joo   +4 more
openaire   +4 more sources

Macromolecular diffusion in crowded solutions

Biophysical Journal, 1993
The effects of crowding on the self or tracer diffusion of macromolecules in concentrated solutions is an important but difficult problem, for which, so far, there has been no rigorous treatment. Muramatsu and Minton suggested a simple model to calculate the diffusion coefficient of a hard sphere among other hard spheres.
Han, J., Herzfeld, J.
openaire   +2 more sources