Results 31 to 40 of about 228,358 (272)

Effects of macromolecular crowding on protein conformational changes. [PDF]

PLoS Computational Biology, 2010
Many protein functions can be directly linked to conformational changes. Inside cells, the equilibria and transition rates between different conformations may be affected by macromolecular crowding.
Hao Dong, Sanbo Qin, Huan-Xiang Zhou
doaj   +4 more sources

Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis [PDF]

Nature Communications, 2022
Amyloid fibrils of β2-microglobulin (β2m) can cause dialysis-related amyloidosis. Here, the authors show that a decrease in serum albumin levels in long-term dialysis deteriorates the inhibitory effects of serum milieux on supersaturation-limited amyloid
Kichitaro Nakajima, Keiichi Yamaguchi, Masahiro Noji, César Aguirre, Kensuke Ikenaka, Hideki Mochizuki, Lianjie Zhou, Hirotsugu Ogi, Toru Ito, Ichiei Narita, Fumitake Gejyo, Hironobu Naiki, Suguru Yamamoto, Yuji Goto   +13 more
doaj   +2 more sources

High-yield cell-derived extracellular matrix bioink via macromolecular crowding for versatile 3D bioprinting. [PDF]

Mater Today Bio
Utami SS, Park H, Kim J, Sung A, Choi MJ, Ryoo GH, Gal CW, Kim I, Yun HS, Choi YJ.   +9 more
europepmc   +2 more sources

A preliminary preclinical assessment of macromolecular crowding in tissue engineering. [PDF]

Sci Prog
Spanoudes K, Cubillo LT, Korntner SH, Gaspar D, Zeugolis DI.   +4 more
europepmc   +2 more sources

Physicochemical cues are not potent regulators of human dermal fibroblast trans-differentiation

Biomaterials and Biosystems, 2023
Due to their inherent plasticity, dermal fibroblasts hold great promise in regenerative medicine. Although biological signals have been well-established as potent regulators of dermal fibroblast function, it is still unclear whether physiochemical cues ...
Christina N.M. Ryan, Eugenia Pugliese, Naledi Shologu, Diana Gaspar, Peadar Rooney, Md Nahidul Islam, Alan O'Riordan, Manus J. Biggs, Matthew D. Griffin, Dimitrios I. Zeugolis   +9 more
doaj   +1 more source

Cell-free protein expression under macromolecular crowding conditions. [PDF]

PLoS ONE, 2011
BackgroundCell-free protein expression (CFPE) comprised of in vitro transcription and translation is currently manipulated in relatively dilute solutions, in which the macromolecular crowding effects present in living cells are largely ignored.
Xumeng Ge, Dan Luo, Jianfeng Xu
doaj   +1 more source

Engineering macromolecular crowding-driven amyloid-mineral hybrid scaffolds for enhanced bone regeneration. [PDF]

Bioact Mater
Ye Y, Li X, Feng H, Zhang S, Zhou X, Li M, Li F, Zhi C, Chen Z, Zhang X, Fang Z, Fang F, Yang P, Zhang X.   +13 more
europepmc   +2 more sources

Macromolecular crowding directs extracellular matrix organization and mesenchymal stem cell behavior. [PDF]

PLoS ONE, 2012
Microenvironments of biological cells are dominated in vivo by macromolecular crowding and resultant excluded volume effects. This feature is absent in dilute in vitro cell culture.
Adam S Zeiger, Felicia C Loe, Ran Li, Michael Raghunath, Krystyn J Van Vliet   +4 more
doaj   +1 more source

Macromolecular Crowding Regulates the Gene Expression Profile by Limiting Diffusion. [PDF]

PLoS Computational Biology, 2016
We seek to elucidate the role of macromolecular crowding in transcription and translation. It is well known that stochasticity in gene expression can lead to differential gene expression and heterogeneity in a cell population.
Mahdi Golkaram, Stefan Hellander, Brian Drawert, Linda R Petzold   +3 more
doaj   +1 more source

FRET-based biosensor moxCRONOS enables quantitative monitoring of macromolecular crowding in organelles and protein aggregates. [PDF]

J Biochem
Nakajima Y, Suzuki H, Miyagi T, Kanekura K.   +3 more
europepmc   +3 more sources