Macromolecular Crowding and DNA: Bridging the Gap between In Vitro and In Vivo [PDF]
International Journal of Molecular Sciences, 2023 Laura Finzi +2 more
exaly +2 more sources
High Macromolecular Crowding in Liposomes from Microfluidics. [PDF]
Adv Sci (Weinh), 2022 The intracellular environment is crowded with macromolecules that influence biochemical equilibria and biomacromolecule diffusion. The incorporation of such crowding in synthetic cells would be needed to mimic the biochemistry of living cells.
Guerzoni LPB +6 more
europepmc +3 more sources
Can Macromolecular Crowding Help Regulate Glutamate Dehydrogenase Activity? [PDF]
ACS OmegaGenesis Rosario +8 more
doaj +2 more sources
Implications of macromolecular crowding and phase separation in bacterial division [PDF]
, 2022 1 p.Bacterial division is an essential process orchestrated by a protein machinery, the divisome [1], forming a ring in the crowded, heterogeneous and compartmentalized bacterial cytoplasm. This ring, the scaffold of which are the GTP-induced polymers of
Margolin, William +6 more
core +1 more source
Physicochemical cues are not potent regulators of human dermal fibroblast trans-differentiation
Biomaterials and Biosystems, 2023 Due to their inherent plasticity, dermal fibroblasts hold great promise in regenerative medicine. Although biological signals have been well-established as potent regulators of dermal fibroblast function, it is still unclear whether physiochemical cues ...
Christina N.M. Ryan +9 more
doaj +1 more source
Macromolecular crowding limits growth under pressure. [PDF]
Nat Phys, 2022 International audienceCells that grow in confined spaces eventually build up mechanical compressive stress. This growth-induced pressure (GIP) decreases cell growth.
Alric B +4 more
europepmc +2 more sources
Macromolecular crowding directs extracellular matrix organization and mesenchymal stem cell behavior. [PDF]
PLoS ONE, 2012 Microenvironments of biological cells are dominated in vivo by macromolecular crowding and resultant excluded volume effects. This feature is absent in dilute in vitro cell culture.
Adam S Zeiger +4 more
doaj +1 more source
Hyaluronic Acid as Macromolecular Crowder in Equine Adipose-Derived Stem Cell Cultures
Cells, 2021 The use of macromolecular crowding in the development of extracellular matrix-rich cell-assembled tissue equivalents is continuously gaining pace in regenerative engineering.
Sergio Garnica-Galvez +6 more
doaj +1 more source
Effect of macromolecular crowding in DNA folding [PDF]
, 2022 Treballs Finals de Grau de Física, Facultat de Física, Universitat de Barcelona, Curs: 2022, Tutora: Isabel Pastor del CampoThe effect of macromolecular crowding has already been studied in protein folding, but there are almost no precedents about its ...
Farré Melero, Arnau
core +6 more sources
The Role of Crowding Forces in Juxtaposing β-Globin Gene Domain Remote Regulatory Elements in Mouse Erythroid Cells. [PDF]
PLoS ONE, 2015 The extremely high concentration of macromolecules in a eukaryotic cell nucleus indicates that the nucleoplasm is a crowded macromolecular solution in which large objects tend to gather together due to crowding forces.
Arkadiy K Golov +2 more
doaj +1 more source