Stress‐dependent macromolecular crowding in the mitochondrial matrix [PDF]
EMBO Journal, 2023 Macromolecules of various sizes induce crowding of the cellular environment. This crowding impacts on biochemical reactions by increasing solvent viscosity, decreasing the water-accessible volume and altering protein shape, function, and interactions.
Elianne P Bulthuis +2 more
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The Differential Response of Proteins to Macromolecular Crowding. [PDF]
PLoS Computational Biology, 2016 The habitat in which proteins exert their function contains up to 400 g/L of macromolecules, most of which are proteins. The repercussions of this dense environment on protein behavior are often overlooked or addressed using synthetic agents such as poly(
Michela Candotti, Modesto Orozco
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Effects of macromolecular crowding on protein conformational changes. [PDF]
PLoS Computational Biology, 2010 Many protein functions can be directly linked to conformational changes. Inside cells, the equilibria and transition rates between different conformations may be affected by macromolecular crowding.
Hao Dong, Sanbo Qin, Huan-Xiang Zhou
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Macromolecular Crowding and DNA: Bridging the Gap between In Vitro and In Vivo [PDF]
International Journal of Molecular Sciences, 2023 Dylan Collette +2 more
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Macromolecular crowding regulates matrix composition and gene expression in human gingival fibroblast cultures. [PDF]
Sci Rep, 2023 Ramalingam R +3 more
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Macromolecular Crowding In Vitro , In Vivo , and In Between [PDF]
Trends in Biochemical Sciences, 2016 Biochemical processes take place in heterogeneous and highly volume-occupied or crowded environments that can considerably influence the reactivity and distribution of participating macromolecules. We summarize here the thermodynamic consequences of excluded-volume and long-range nonspecific intermolecular interactions for macromolecular reactions in ...
Germán Rivas, Allen P. Minton
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An upper limit for macromolecular crowding effects [PDF]
BMC Biophysics, 2011 Abstract Background Solutions containing high macromolecule concentrations are predicted to affect a number of protein properties compared to those properties in dilute solution. In cells, these macromolecular crowders have a large range of sizes and can occupy 30% or more of the available volume.
Andrew C. Miklos +4 more
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Can Macromolecular Crowding Help Regulate Glutamate Dehydrogenase Activity? [PDF]
ACS OmegaGenesis Rosario +8 more
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High Macromolecular Crowding in Liposomes from Microfluidics [PDF]
Advanced Science, 2022 Luis P B Guerzoni +2 more
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Direct activation of HSF1 by macromolecular crowding and misfolded proteins. [PDF]
PLoS OneSimoncik O +9 more
europepmc +2 more sources