Results 21 to 30 of about 16,667 (258)

A didactic model of macromolecular crowding effects on protein folding. [PDF]

PLoS ONE, 2010
A didactic model is presented to illustrate how the effect of macromolecular crowding on protein folding and association is modeled using current analytical theory and discrete molecular dynamics.
Douglas Tsao, Allen P Minton, Nikolay V Dokholyan   +2 more
doaj   +3 more sources

The Differential Response of Proteins to Macromolecular Crowding. [PDF]

PLoS Computational Biology, 2016
The habitat in which proteins exert their function contains up to 400 g/L of macromolecules, most of which are proteins. The repercussions of this dense environment on protein behavior are often overlooked or addressed using synthetic agents such as poly(
Michela Candotti, Modesto Orozco
doaj   +5 more sources

Macromolecular crowding regulates matrix composition and gene expression in human gingival fibroblast cultures. [PDF]

Sci Rep, 2023
Ramalingam R, Jiang G, Larjava H, Häkkinen L.   +3 more
europepmc   +3 more sources

Can Macromolecular Crowding Help Regulate Glutamate Dehydrogenase Activity? [PDF]

ACS Omega
Genesis Rosario, Andrea Desrochers, Alec Robitaille, Emily Rundlett, Daniel Myšák, Zuzana Sochorová Vokáčová, Štěpán Timr, Eva Pluhařová, Kristin M. Slade   +8 more
doaj   +2 more sources

Direct activation of HSF1 by macromolecular crowding and misfolded proteins. [PDF]

PLoS One
Simoncik O, Tichy V, Durech M, Hernychova L, Trcka F, Uhrik L, Bardelcik M, Coates PJ, Vojtesek B, Muller P.   +9 more
europepmc   +2 more sources

Physicochemical cues are not potent regulators of human dermal fibroblast trans-differentiation

Biomaterials and Biosystems, 2023
Due to their inherent plasticity, dermal fibroblasts hold great promise in regenerative medicine. Although biological signals have been well-established as potent regulators of dermal fibroblast function, it is still unclear whether physiochemical cues ...
Christina N.M. Ryan, Eugenia Pugliese, Naledi Shologu, Diana Gaspar, Peadar Rooney, Md Nahidul Islam, Alan O'Riordan, Manus J. Biggs, Matthew D. Griffin, Dimitrios I. Zeugolis   +9 more
doaj   +1 more source

Cell-free protein expression under macromolecular crowding conditions. [PDF]

PLoS ONE, 2011
BackgroundCell-free protein expression (CFPE) comprised of in vitro transcription and translation is currently manipulated in relatively dilute solutions, in which the macromolecular crowding effects present in living cells are largely ignored.
Xumeng Ge, Dan Luo, Jianfeng Xu
doaj   +1 more source

Macromolecular crowding directs extracellular matrix organization and mesenchymal stem cell behavior. [PDF]

PLoS ONE, 2012
Microenvironments of biological cells are dominated in vivo by macromolecular crowding and resultant excluded volume effects. This feature is absent in dilute in vitro cell culture.
Adam S Zeiger, Felicia C Loe, Ran Li, Michael Raghunath, Krystyn J Van Vliet   +4 more
doaj   +1 more source

Macromolecular Crowding Regulates the Gene Expression Profile by Limiting Diffusion. [PDF]

PLoS Computational Biology, 2016
We seek to elucidate the role of macromolecular crowding in transcription and translation. It is well known that stochasticity in gene expression can lead to differential gene expression and heterogeneity in a cell population.
Mahdi Golkaram, Stefan Hellander, Brian Drawert, Linda R Petzold   +3 more
doaj   +1 more source

Hyaluronic Acid as Macromolecular Crowder in Equine Adipose-Derived Stem Cell Cultures

Cells, 2021
The use of macromolecular crowding in the development of extracellular matrix-rich cell-assembled tissue equivalents is continuously gaining pace in regenerative engineering.
Sergio Garnica-Galvez, Stefanie H. Korntner, Ioannis Skoufos, Athina Tzora, Nikolaos Diakakis, Nikitas Prassinos, Dimitrios I. Zeugolis   +6 more
doaj   +1 more source