Results 31 to 40 of about 16,667 (258)
The Role of Crowding Forces in Juxtaposing β-Globin Gene Domain Remote Regulatory Elements in Mouse Erythroid Cells. [PDF]
PLoS ONE, 2015 The extremely high concentration of macromolecules in a eukaryotic cell nucleus indicates that the nucleoplasm is a crowded macromolecular solution in which large objects tend to gather together due to crowding forces.
Arkadiy K Golov +2 more
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Macromolecular crowding: Sensing without a sensor
Current Opinion in Cell Biology, 2023 All living cells are crowded with macromolecules. Crowding can directly modulate biochemical reactions to various degrees depending on the sizes, shapes, and binding affinities of the reactants. Here, we explore the possibility that cells can sense and adapt to changes in crowding through the widespread modulation of biochemical reactions without the ...
Holt, Liam, Delarue, Morgan
openaire +4 more sources
Conformation-changing enzymes and macromolecular crowding
Physical Chemistry Chemical Physics, 2021 We study how crowding affects the activity and catalysis-enhanced diffusion of enzymes and passive tracers by employing a fluctuating-dumbbell model of conformation-changing enzymes.
Tomasz Skóra +2 more
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eLife, 2020 Cellular aging is a multifactorial process that is characterized by a decline in homeostatic capacity, best described at the molecular level. Physicochemical properties such as pH and macromolecular crowding are essential to all molecular processes in ...
Sara N Mouton +9 more
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The contrasting effect of macromolecular crowding on amyloid fibril formation. [PDF]
PLoS ONE, 2012 Amyloid fibrils associated with neurodegenerative diseases can be considered biologically relevant failures of cellular quality control mechanisms.
Qian Ma +7 more
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Biochemistry and Biophysics Reports, 2021 In order to better understand how the complex, densely packed, heterogeneous milieu of a cell influences enzyme kinetics, we exposed opposing reactions catalyzed by yeast alcohol dehydrogenase (YADH) to both synthetic and protein crowders ranging from 10
Xander E. Wilcox +2 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2021 Skin fibrosis still constitutes an unmet clinical need. Although pharmacological strategies are at the forefront of scientific and technological research and innovation, their clinical translation is hindered by the poor predictive capacity of the ...
João Q. Coentro +8 more
doaj +1 more source
Osmotic pressure: resisting or promoting DNA ejection from phage [PDF]
, 2008 Recent in vitro experiments have shown that DNA ejection from bacteriophage can be partially stopped by surrounding osmotic pressure when ejected DNA is digested by DNase I on the course of ejection.
Castelnovo, Martin +4 more
core +3 more sources
A physical model of cell metabolism [PDF]
, 2018 Cell metabolism is characterized by three fundamental energy demands: to sustain cell maintenance, to trigger aerobic fermentation and to achieve maximum metabolic rate.
Fernandez-de-Cossio-Diaz, Jorge +1 more
core +2 more sources
Impact of limited solvent capacity on metabolic rate, enzyme activities, and metabolite concentrations of S. cerevisiae glycolysis [PDF]
, 2008 The cell's cytoplasm is crowded by its various molecular components, resulting in a limited solvent capacity for the allocation of new proteins, thus constraining various cellular processes such as metabolism.
Barabási, AL +3 more
core +1 more source