Results 41 to 50 of about 16,667 (258)

Influence of Nanoparticle Size and Shape on Oligomer Formation of an Amyloidogenic Peptide [PDF]

, 2011
Understanding the influence of macromolecular crowding and nanoparticles on the formation of in-register $\beta$-sheets, the primary structural component of amyloid fibrils, is a first step towards describing \emph{in vivo} protein aggregation and ...
Allen M. P., Asakura S., Auer S., Batra J., Behe M., Bernard R. Brooks, Brooks B. R., Chan J. C. C., Cheung M. S., Chiti F., Colvin V. L., Colvin V. L., Cotter M. A., Cunha S., D. Thirumalai, del Álamao M., Dhar A., Dima R. I., Edward P. O’Brien, Elcock A. H., Fleer G. J., Flory P. J., Hall D., Hofrichter J., Jaroniec C. P., Jaroniec C. P., John. E. Straub, Lazaridis T., Lindner R. A., Linse S., Magno A., McGuffee S. R., Nelson R., Nelson R., Nguyen P. H., Petty S. A., Pierotti R. A., Rohrig U. F., Ross P. D., Sacchettini J. C., Schreiber G., Shaw M. R., Stagg L., Straub J. E., Tarus B., Tellam R. L., Tycko R., Walter H., Wu C., Zhou H. X., Zimmerman S. B.   +50 more
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Macromolecular diffusion in crowded solutions

Biophysical Journal, 1993
The effects of crowding on the self or tracer diffusion of macromolecules in concentrated solutions is an important but difficult problem, for which, so far, there has been no rigorous treatment. Muramatsu and Minton suggested a simple model to calculate the diffusion coefficient of a hard sphere among other hard spheres.
Han, J., Herzfeld, J.
openaire   +2 more sources

Seaweed polysaccharides as macromolecular crowding agents

International Journal of Biological Macromolecules, 2020
Development of mesenchymal stem cell-based tissue engineered implantable devices requires prolonged in vitro culture for the development of a three-dimensional implantable device, which leads to phenotypic drift, thus hindering the clinical translation and commercialisation of such approaches.
De Pieri, Andrea, Rana, Shubhasmin, Korntner, Stefanie, Zeugolis, Dimitrios I.   +3 more
openaire   +2 more sources

A combined physicochemical approach towards human tenocyte phenotype maintenance

Materials Today Bio, 2021
During in vitro culture, bereft of their optimal tissue context, tenocytes lose their phenotype and function. Considering that tenocytes in their native tissue milieu are exposed simultaneously to manifold signals, combination approaches (e.g.
C.N.M. Ryan, E. Pugliese, N. Shologu, D. Gaspar, P. Rooney, Md N. Islam, A. O'Riordan, M.J. Biggs, M.D. Griffin, D.I. Zeugolis   +9 more
doaj   +1 more source

Crowding effects in vehicular traffic [PDF]

, 2012
While the impact of crowding on the diffusive transport of molecules within a cell is widely studied in biology, it has thus far been neglected in traffic systems where bulk behavior is the main concern.
Combinido, Jay Samuel L., Lim, May T.
core   +3 more sources

Guiding Protein Aggregation with Macromolecular Crowding [PDF]

Biochemistry, 2008
Macromolecular crowding is expected to have a significant effect on protein aggregation. In the present study we analyzed the effect of macromolecular crowding on fibrillation of four proteins, bovine S-carboxymethyl-alpha-lactalbumin (a disordered form of the protein with reduced three out of four disulfide bridges), human insulin, bovine core ...
Munishkina, Larissa A., Ahmad, Atta, Fink, Anthony L., Uversky, Vladimir N.   +3 more
openaire   +3 more sources

All atom insights into the impact of crowded environments on protein stability by NMR spectroscopy

Nature Communications, 2020
The precise effects of crowding on protein folding have been difficult to establish. Here the authors apply multidimensional high-resolution NMR spectroscopy to provide insight on the local impact of macromolecular crowding on the thermodynamic stability
Birgit Köhn, Michael Kovermann
doaj   +1 more source

Serine biosynthesis with one carbon catabolism represents a novel pathway for ATP generation in cells using alternative glycolysis with zero net ATP production [PDF]

, 2011
Recent experimental evidence indicates that some cancer cells have an alternative glycolysis pathway with net zero ATP production, implying that upregulation of glycolysis in these cells may not be related to the generation of ATP.
Alexei Vazquez, Elke K. Markert, Zoltan N. Oltvai   +2 more
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Effects of Macromolecular Crowding on Genetic Networks [PDF]

Biophysical Journal, 2011
The intracellular environment is crowded with proteins, DNA, and other macromolecules. Under physiological conditions, macromolecular crowding can alter both molecular diffusion and the equilibria of bimolecular reactions and therefore is likely to have a significant effect on the function of biochemical networks.
M.J. Morelli, R.J. Allen, P.R. ten Wolde (Pieter Rein)   +2 more
openaire   +2 more sources

The effect of macromolecular crowding on the electrostatic component of barnase-barstar binding: a computational, implicit solvent-based study. [PDF]

PLoS ONE, 2014
Macromolecular crowding within the cell can impact both protein folding and binding. Earlier models of cellular crowding focused on the excluded volume, entropic effect of crowding agents, which generally favors compact protein states.
Helena W Qi, Priyanka Nakka, Connie Chen, Mala L Radhakrishnan   +3 more
doaj   +1 more source