Results 101 to 110 of about 793,649 (316)
Molecular Oncology, EarlyView.Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale +9 more
wiley +1 more source
Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo
Frontiers in Immunology, 2019 Macrophage phenotypes are poorly characterized in disease systems in vivo. Appropriate macrophage activation requires complex coordination of local microenvironmental cues and cytokine signaling.
Amy Lewis, Philip M. Elks
doaj +1 more source
Molecular Oncology, EarlyView.The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu +3 more
wiley +1 more source
Journal of Lipid Research, 2003 Human monocyte-derived foam cell macrophages (HMFCs) are resistant to cholesterol efflux mediated by physiological acceptors. The role of the plasma membrane in regulating depletion of free cholesterol (FC) and of cholesteryl ester (CE) was investigated ...
Sue M. Liu +6 more
doaj
Heparanase and macrophage interplay in the onset of liver fibrosis [PDF]
, 2017 The heparan sulfate endoglycosidase heparanase (HPSE) is involved in tumor growth, chronic inflammation and fibrosis. Since a role for HPSE in chronic liver disease has not been demonstrated to date, the current study was aimed at investigating the ...
Crescenzi, Marika +5 more
core +2 more sources
Estimating the number of tissue resident macrophages [PDF]
arXiv, 2016 I provide a simple estimation for the number of macrophages in a tissue, arising from the hypothesis that they should keep infections below a certain threshold, above which neutrophils are recruited from blood circulation. The estimation reads Nm=a Ncel^{\alpha}/Nmax, where a is a numerical coefficient, the exponent {\alpha} is near 2/3, and Nmax is ...
arxiv
Effects of nanoparticles on murine macrophages [PDF]
, 2011 Metallic nanoparticles are more and more widely used in an increasing number of applications. Consequently, they are more and more present in the environment, and the risk that they may represent for human health must be evaluated. This requires to increase our knowledge of the cellular responses to nanoparticles. In this context, macrophages appear as
arxiv +1 more source
ACTIVATION OF CYTOTOXIC MACROPHAGE WITH MACROPHAGE
The KITAKANTO Medical Journal, 1978 Mouse peritoneal exudate macrophages induced by peptone (macrophages) were activated with a lymphokine, macrophage activating factor (MAF), and became cytotoxic against various tumor cells. Peritoneal resident adherent-cells from normal mice were not activated with MAF.When macrophages were incubated with aggregated human immunoglobulin G (agg-HGG) for
openaire +3 more sources
Molecular Oncology, EarlyView.Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam +2 more
wiley +1 more source
Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages [PDF]
, 2007 Genetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)‐induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy.
Barleon +47 more
core +1 more source