Results 81 to 90 of about 1,540,630 (392)

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

The double-edged sword effect of macrophage targeting delivery system in different macrophage subsets related diseases

Journal of Nanobiotechnology, 2020
Background Monocyte/macrophage-targeting delivery systems (MTDSs) have been focused upon as an emerging routine for delivering drugs to treat various macrophage-related diseases.
Yuchuan Yuan, Ling Long, Jiaxing Liu, Yongyao Lin, Cuiping Peng, Yue Tang, Xuemei Zhou, Shuhui Li, Chengyuan Zhang, Xiaohui Li, Xing Zhou   +10 more
doaj   +1 more source

CD24 signalling through macrophage Siglec-10 is a new target for cancer immunotherapy

Nature, 2019
Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are capable of evading clearance by macrophages through the overexpression of anti-
Amira A. Barkal, Rachel E. Brewer, Maxim Markovic, M. Kowarsky, Sammy A. Barkal, Balyn W. Zaro, V. Krishnan, J. Hatakeyama, O. Dorigo, Layla J Barkal, I. Weissman   +10 more
semanticscholar   +1 more source

Macrophage-Based Approaches for Cancer Immunotherapy

Cancer Research, 2020
Adoptive cell therapy with genetically modified T cells has generated exciting outcomes in hematologic malignancies, but its application to solid tumors has proven challenging.
Nicholas R. Anderson, Nicholas G. Minutolo, S. Gill, M. Klichinsky   +3 more
semanticscholar   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

MHC class II+ macrophage differentiation is impaired in metastasized lungs via PGE2 receptor EP2

Cell Reports
Summary: Monocytes differentiate into macrophages (Mφs) to facilitate lung metastasis, but the monocyte-to-Mφ transition during this process is not well understood.
Mi Reu Jeong, Jung Woo Hwang, Murim Choi, Seung Hyeok Seok   +3 more
doaj   +1 more source

The Contribution of Hepatic Macrophage Heterogeneity during Liver Regeneration after Partial Hepatectomy in Mice

Journal of Immunology Research, 2022
Background and Aim. Hepatic macrophage is a heterogenetic population in origin and function. It is known to participate in the coordination of all phases of liver regeneration after partial hepatectomy (PHx). However, as yet, there is no research focused
Pengfei Ma, Wenchao Zhao, Chunchen Gao, Zhiwei Liang, Longshuan Zhao, Hongyan Qin, Xiaolin Sun   +6 more
doaj   +1 more source

SOCS Proteins in Macrophage Polarization and Function [PDF]

, 2014
Peer reviewedPublisher ...
Wilson, Heather M
core   +2 more sources

Autophagy-dependent ferroptosis drives tumor-associated macrophage polarization via release and uptake of oncogenic KRAS protein

Autophagy, 2020
KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive.
Enyong Dai, Leng Han, Jiao Liu, Yangchun Xie, G. Kroemer, D. Klionsky, H. Zeh, R. Kang, Jing Wang, D. Tang   +9 more
semanticscholar   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source