Results 81 to 90 of about 793,649 (316)
Dynamical Model of Mild Atherosclerosis: Applied Mathematical Aspects [PDF]
arXiv, 2022 Atherosclerosis is a chronic inflammatory disease occurs due to plaque accumulation in the inner artery wall. In atherosclerotic plaque formation monocytes and macrophages play a significant role in controlling the disease dynamics. In the present article, the entire biochemical process of atherosclerotic plaque formation is presented in terms of an ...
arxiv
FEBS Letters, EarlyView.The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva +1 more
wiley +1 more source
Pentose Phosphate Pathway Regulates Tolerogenic Apoptotic Cell Clearance and Immune Tolerance
Frontiers in Immunology, 2022 The efficient removal of apoptotic cells (ACs), a process termed as efferocytosis, is essential for immune homeostasis. While recent work has established an important interplay between efferocytosis and cellular metabolic changing, underlying mechanisms ...
Dan He +7 more
doaj +1 more source
"Re-educating" tumor-associated macrophages by targeting NF-kappaB [PDF]
, 2008 The nuclear factor kappaB (NF-kappaB) signaling pathway is important in cancer-related inflammation and malignant progression. Here, we describe a new role for NF-kappaB in cancer in maintaining the immunosuppressive phenotype of tumor-associated ...
Balkwill, F.R. +7 more
core +2 more sources
Molecular responses of mouse macrophages to copper and copper oxide nanoparticles inferred from proteomic analyses [PDF]
Mol Cell Proteomics 12, 11 (2013) 3108-22, 2013 The molecular responses of macrophages to copper-based nanoparticles have been investigated via a combination of proteomic and biochemical approaches, using the RAW264.7 cell line as a model. Both metallic copper and copper oxide nanoparticles have been tested, with copper ion and zirconium oxide nanoparticles used as controls.
arxiv +1 more source
Macrophages in Marseille [PDF]
Immunity, 2013 Immunology has recently witnessed several new developments in understanding the biology of macrophages. These exciting developments were the focus of a conference in Marseille, France, in January 2013. This conference is summarized here.
openaire +2 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Three-Dimensional Culture Decreases the Angiogenic Ability of Mouse Macrophages
Frontiers in Immunology, 2021 Macrophages play important roles in angiogenesis; however, previous studies on macrophage angiogenesis have focused on traditional 2D cultures. In this study, we established a 3D culture system for macrophages using collagen microcarriers and assessed ...
Haoxin Shi +7 more
doaj +1 more source
Expression of factor V by resident macrophages boosts host defense in the peritoneal cavity [PDF]
, 2019 Macrophages resident in different organs express distinct genes, but understanding how this diversity fits into tissue-specific features is limited. Here, we show that selective expression of coagulation factor V (FV) by resident peritoneal macrophages ...
Broze, George J +12 more
core +1 more source
Epigenomics of macrophages [PDF]
Immunological Reviews, 2014 SummaryMacrophages play essential roles in tissue homeostasis, pathogen elimination, and tissue repair. A defining characteristic of these cells is their ability to efficiently adapt to a variety of abruptly changing and complex environments. This ability is intrinsically linked to a capacity to quickly alter their transcriptome, and this is tightly ...
Christopher K. Glass, David Gosselin
openaire +2 more sources