Results 81 to 90 of about 1,133,037 (342)

The significance of M1/M2 macrophage-like monocytes in children with systemic lupus erythematosus

European Journal of Inflammation, 2019
Monocytes/macrophages are important in the development of systemic lupus erythematosus. To research M1 and M2 macrophage-like monocytes in the peripheral blood of children with systemic lupus erythematosus and explore the clinical significance, M1 and M2
Xiao-Ling Niu, Dan Feng, Sheng Hao, Xin-Yu Kuang, Ying Wu, Guang-Hua Zhu, Wen-Yan Huang   +6 more
doaj   +1 more source

Reduced Phagocytic Capacity of Blood Monocyte/Macrophages in Tuberculosis Patients Is Further Reduced by Smoking. [PDF]

, 2016
Tuberculosis (TB) and tobacco use are two major alarming global health issues posing immense threats to human populations. Mycobacterium tuberculosis (MTB) by activation of macrophages could induce the sequences of cells activation and releases of ...
Adcock, IM, Aryanpur, M, Garssen, J, Masjedi, MR, Mortaz, E, Mozafarian, A, Sharifi, H, Tabarsi, P   +7 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology
Immune status critically affects cancer progression and therapy responses. This study aimed to identify plasma proteome changes in immunosuppressive cancer and potential biomarkers predicting systemic immunosuppression.
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
doaj   +1 more source

Altered ISGylation drives aberrant macrophage-dependent immune responses during SARS-CoV-2 infection [PDF]

, 2021
Deeksha Munnur, Qi Wen Teo, Denzel Eggermont, Horace H.Y. Lee, Fabien Théry, Julian Ho, Sophie Wilhelmina van Leur, Wilson W. Ng, Lewis Siu, Antje Beling, Hidde L. Ploegh, Adán Pinto-Fernández, Andreas Damianou, Benedikt M. Kessler, Francis Impens, Chris Ka Pun Mok, Sumana Sanyal   +16 more
openalex   +1 more source

Macrophages in obesity

Cellular Immunology, 2018
Obesity is a worldwide public health concern yet no safe therapies are currently available. The activity of sympathetic neurons is necessary and sufficient for fat mass reduction, via norepinephrine (NE) signaling. Macrophage accumulation in the adipose tissue is thought to play the central role in the onset of obesity, yet their relation to NE has ...
Pirzgalska, R, Domingos, A
openaire   +2 more sources

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source

Kinetic studies of Candida parapsilosis phagocytosis by macrophages and detection of intracellular survival mechanisms [PDF]

, 2014
Peer reviewedPublisher ...
Alonso, Maria F, Bain, Judith M, Erwig, Lars Peter, Gácser, Attila, Jankovics, Ferenc, Papp, Csaba, Tóth, Adél, Tóth, Renáta, Vágvölgyi, Csaba   +8 more
core   +4 more sources

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, EarlyView.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Hypoxia Induces Macrophage tnfa Expression via Cyclooxygenase and Prostaglandin E2 in vivo

Frontiers in Immunology, 2019
Macrophage phenotypes are poorly characterized in disease systems in vivo. Appropriate macrophage activation requires complex coordination of local microenvironmental cues and cytokine signaling.
Amy Lewis, Philip M. Elks
doaj   +1 more source