Results 1 to 10 of about 4,994,603 (399)

Macrophage Activation Syndrome [PDF]

The Indian Journal of Pediatrics, 2015
Macrophage activation syndrome (MAS) is a potentially life-threatening complication of rheumatic diseases such as systemic juvenile idiopathic arthritis (sJIA) and systemic lupus erythematosus.
Clarke, Sarah L N, Ramanan, Athimalaipet V, Sen, Ethan S   +2 more
core   +9 more sources

Metabolic Regulation of Macrophage Activation

Journal of Innate Immunity, 2021
Macrophages, the central mediators of innate immune responses, being in the first-line of defense, they have to readily respond to pathogenic or tissue damage signals to initiate the inflammatory cascade.
Ourania Kolliniati, Eleftheria Ieronymaki, Eleni Vergadi, Christos Tsatsanis   +3 more
doaj   +2 more sources

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. [PDF]

Nature Communications, 2018
Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a vascular niche that controls alternative macrophage activation in glioblastoma (GBM).
Brem, Steven, Dahmane, Nadia, Duan, Hao, Fan, Yi, Gong, Yanqing, He, Zhenqiang, Hidalgo, Juan, Huang, Menggui, Liu, Tianrun, Ma, Peihong, Mou, Yonggao, O'Rourke, Donald M, Wang, Qirui, Wang, Yanling, Xu, Haineng, Zamvil, Scott S, Zhang, Lin, Zhang, Zhenfeng   +17 more
core   +4 more sources

METTL3/RBM15 augments the stability of Kdm6b mRNA and promotes STAT1-mediated macrophage activation and atherosclerosis [PDF]

Experimental and Molecular Medicine
Atherosclerosis is the underlying cause of cardiovascular disease. Recent studies have shown that N 6-methyladenosine (m6A) modification in macrophages is associated with atherosclerosis progression.
Ning Huangfu, Fang Li, Chenqiu Wang, Shouyi Jin, Xiaoya Zheng, Yingsong Wang, Tianxiang Fang, Jiaxi Shen, Yanan Yu, Liguo Jian, Datun Qi, Wenting Zhao, Dongdong Jian   +12 more
doaj   +2 more sources

Macrophage activation syndrome and COVID-19

Inflammation and Regeneration, 2020
An emerging, rapidly spreading coronavirus SARS-CoV-2 is causing a devastating pandemic. As we have not developed curative medicine and effective vaccine, the end of this life-threatening infectious disease is still unclear.
Ryo Otsuka, Ken-ichiro Seino
doaj   +2 more sources

Macrophage activation and polarization.

Frontiers in Bioscience, 2008
Macrophages are widely distributed immune system cells that play an indispensable role in homeostasis and defense. They can be phenotypically polarized by the microenvironment to mount specific functional programs. Polarized macrophages can be broadly classified in two main groups: classically activated macrophages (or M1), whose prototypical ...
F. Martínez, A. Sica, A. Mantovani, M. Locati   +3 more
semanticscholar   +4 more sources

Metabolism Supports Macrophage Activation [PDF]

Frontiers in Immunology, 2017
Macrophages are found in most tissues of the body, where they have tissue- and context-dependent roles in maintaining homeostasis as well as coordinating adaptive responses to various stresses.
Ping-Chih Ho, P. Italiani, T. Horng, P. K. Langston, Munehiko Shibata   +4 more
semanticscholar   +4 more sources

RANKL promotes airway inflammation via pro-inflammatory alveolar macrophage activation in COPD [PDF]

Respiratory Research
Background Chronic airway inflammation is a key mechanism involved in the pathogenesis and progression of chronic obstructive pulmonary disease (COPD).
Lu Zhou, Baiquan Zhang, Huanqin Wang, Jintao Liu, Lijun Miao   +4 more
doaj   +2 more sources

Chronic macrophage activation derails muscle repair by disrupting mannose-receptor-linked plasticity revealed by endogenous irg1/acod1 tracking [PDF]

Nature Communications
Macrophages are central drivers of chronic inflammation, yet how a sustained inflammatory state alters their function remains unclear. Using GFP knock-in zebrafish targeting irg1/acod1 that marks macrophage activation, we track the dynamic transitions of
Caroline G. Spencer, Matthew Hamilton, Ethan Bedsole, Yingshan N. Wei, Alison M. Rojas, Andrew Burciu, John Zhu, Keith Z. Sabin, Celia E. Shiau   +8 more
doaj   +2 more sources

Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish

Frontiers in Immunology, 2021
Immediately after a wound, macrophages are activated and change their phenotypes in reaction to danger signals released from the damaged tissues. The cues that contribute to macrophage activation after wounding in vivo are still poorly understood ...
Tamara Sipka, Romain Peroceschi, Rahma Hassan-Abdi, Martin Groß, Felix Ellett, Felix Ellett, Christina Begon-Pescia, Catherine Gonzalez, Georges Lutfalla, Mai Nguyen-Chi   +9 more
doaj   +1 more source