Results 1 to 10 of about 128,642 (75)

Damage-Induced Calcium Signaling and Reactive Oxygen Species Mediate Macrophage Activation in Zebrafish

Frontiers in Immunology, 2021
Immediately after a wound, macrophages are activated and change their phenotypes in reaction to danger signals released from the damaged tissues. The cues that contribute to macrophage activation after wounding in vivo are still poorly understood ...
Tamara Sipka, Romain Peroceschi, Rahma Hassan-Abdi, Martin Groß, Felix Ellett, Felix Ellett, Christina Begon-Pescia, Catherine Gonzalez, Georges Lutfalla, Mai Nguyen-Chi   +9 more
doaj   +1 more source

Solanum nigrum induces macrophage activation through TLR4-mediated activation of JNK and macrophage autophagy through TLR4-mediated activation of p38 and JNK

Food and Agricultural Immunology, 2022
In this study, we investigated the effect of Solanum nigrum aerial parts (SNAP) on macrophage activation and macrophage autophagy in RAW264.7 cells. SNAP increased the production of immunostimulatory factors and phagocytosis in RAW264.7 cells.
Ju Hyung Yu, Min Yeong Choi, So Jung Park, Na Gyeong Geum, Jae Won Lee, Gwang Hun Park, Hyun Ji Eo, Jin Boo Jeong   +7 more
doaj   +1 more source

In Vitro Screening Method for Characterization of Macrophage Activation Responses

Methods and Protocols, 2022
Macrophage activation refers to the enhanced functionality of macrophages in response to endogenous or exogenous stimuli. Due to the existence of limitless stimuli and a multitude of receptors on macrophage surfaces, the nature of activation (or acquired
Brandon W. Lewis, Sonika Patial, Yogesh Saini   +2 more
doaj   +1 more source

Effects of a mesoporous bioactive glass on osteoblasts, osteoclasts and macrophages [PDF]

J. Colloid Interface Sci. 528, 309-320 (2018), 2021
A mesoporous bioactive glass (MBG) of molar composition 75SiO2-20CaO-5P2O5 (MBG-75S) has been synthetized as a potential bioceramic for bone regeneration purposes. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), nitrogen adsorption studies and transmission electron microscopy (TEM) demonstrated that MBG-75Spossess a highly ...
arxiv   +1 more source

ARRB1 suppresses the activation of hepatic macrophages via modulating endoplasmic reticulum stress in lipopolysaccharide-induced acute liver injury

Cell Death Discovery, 2021
Acute liver injury (ALI) caused by multiple inflammatory responses is a monocyte-/macrophage-mediated liver injury that is associated with high morbidity and mortality. Liver macrophage activation is a vital event that triggers ALI.
Yiming Lei, Sizhe Wan, Huiling Liu, Haoxiong Zhou, Lingjun Chen, Yidong Yang, Bin Wu   +6 more
doaj   +1 more source

Neuropathology in COVID-19 autopsies is defined by microglial activation and lesions of the white matter with emphasis in cerebellar and brain stem areas

Frontiers in Neurology, 2023
IntroductionThis study aimed to investigate microglial and macrophage activation in 17 patients who died in the context of a COVID-19 infection in 2020 and 2021.MethodsThrough immunohistochemical analysis, the lysosomal marker CD68 was used to detect ...
Julian A. Stein, Manuel Kaes, Sigrun Smola, Sigrun Smola, Walter J. Schulz-Schaeffer   +4 more
doaj   +1 more source

Nicotinamide Mononucleotide Alleviates LPS-Induced Inflammation and Oxidative Stress via Decreasing COX-2 Expression in Macrophages

Frontiers in Molecular Biosciences, 2021
Macrophage activation is an important process in controlling infection, but persistent macrophage activation leads to chronic inflammation and diseases, such as tumor progression, insulin resistance and atherosclerosis.
Jing Liu, Zhaoyun Zong, Wenhao Zhang, Yuling Chen, Xueying Wang, Jie Shen, Changmei Yang, Xiaohui Liu, Haiteng Deng   +8 more
doaj   +1 more source

Incorporation and effects of mesoporous SiO2-CaO nanospheres loaded with ipriflavone on osteoblast/osteoclast cocultures [PDF]

Eur. J. Pharm. Biopharm. 133, 258-268 (2018), 2021
Mesoporous nanospheres in the system SiO2-CaO (NanoMBGs) with a hollow core surrounded by a radial arrangement of mesopores were characterized, labeled with FITC (FITC-NanoMBGs) and loaded with ipriflavone (NanoMBG-IPs) in order to evaluate their incorporation and their effects on both osteoblasts and osteoclasts simultaneously and maintaining the ...
arxiv   +1 more source

MAP kinase phosphatase 2 regulates macrophage-adipocyte interaction. [PDF]

PLoS ONE, 2015
Inflammation is critical for the development of obesity-associated metabolic disorders. This study aims to investigate the role of mitogen-activated protein kinase phosphatase 2 (MKP-2) in inflammation during macrophage-adipocyte interaction.White ...
Huipeng Jiao, Peng Tang, Yongliang Zhang
doaj   +1 more source

Tranglutaminase 2 contributes to the asthmatic inflammation by modulating activation of alveolar macrophages

Immunity, Inflammation and Disease, 2021
Background Transglutaminase 2 (TG2), a multifunctional calcium‐dependent acyltransferase, is upregulated in asthmatic airways and reported to play a role in the pathogenesis of allergic asthma.
Hyun Seung Lee, Da‐Eun Park, Boram Bae, Keunhee Oh, Jae Woo Jung, Dong‐Sup Lee, In‐Gyu Kim, Sang‐Heon Cho, Hye‐Ryun Kang   +8 more
doaj   +1 more source