Results 101 to 110 of about 4,994,603 (399)

Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironment

Genome Biology, 2017
BackgroundTumor-associated macrophages (TAMs) are abundant in gliomas and immunosuppressive TAMs are a barrier to emerging immunotherapies. It is unknown to what extent macrophages derived from peripheral blood adopt the phenotype of brain-resident ...
Sören Müller, Gary Kohanbash, S. Liu, Beatriz Alvarado, Diego A. Carrera, A. Bhaduri, P. Watchmaker, Garima Yagnik, Elizabeth Di Lullo, M. Malatesta, N. Amankulor, A. Kriegstein, D. Lim, M. Aghi, H. Okada, A. Diaz   +15 more
semanticscholar   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Macrophage activation syndrome: early diagnosis is key

Open Access Rheumatology : Research and Reviews, 2018
Macrophage activation syndrome (MAS) is a life-threatening condition, and it is a subset of hemophagocytic lymphohistiocytosis (HLH). The clinical features include a persistent high-grade fever, hepatosplenomegaly, lymphadenopathy, hemorrhagic ...
Butsabong Lerkvaleekul, S. Vilaiyuk
semanticscholar   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Macrophage WDFY3 mitigates autoimmunity by enhancing efferocytosis and suppressing T cell activation in mice

Nature Communications
Efficient efferocytosis is crucial for immune homeostasis. Conversely, excessive apoptotic cell (AC) death and impaired macrophage efferocytosis lead to autoantigen release, autoantibody production, and immune activation.
Xun Wu, Ziyi Wang, Katherine R. Croce, Fang Li, Jian Cui, Vivette D. D’Agati, Rajesh K. Soni, Ira Tabas, Ai Yamamoto, Hanrui Zhang   +9 more
doaj   +1 more source

Interactions between vaccinia virus and sensitized macrophages in vitro [PDF]

, 1975
The action of peritoneal exudate cells (PEC) from normal and vaccinia virus infected mice on infectious vaccinia virus particles was investigatedin vitro. PEC from immune mice showed a significantly higher infectivity titre reduction (virus clearance, VC)
A. V. Boand, B. Rager-Zismann, B. Vernon-Roberts, C. A. Mims, C. A. Mims, D. R. Ginder, F. B. Bang, F. R. Avila, G. B. Mackaness, J. A. Roberts, J. G. Stevens, K. T. Brunner, L. F. Reed, M. Nishmi, M. Rabinowitch, M. Rabinowitch, M. S. Hirsch, R. Benda, R. Evans, R. Gallily, R. J. North, R. M. Schultz, R. T. Johnson, S. Ueda, W. A. F. Tompkins, W. Dabrowski   +25 more
core   +1 more source

An unexpected link between fatty acid synthase and cholesterol synthesis in proinflammatory macrophage activation

Journal of Biological Chemistry, 2018
Different immune activation states require distinct metabolic features and activities in immune cells. For instance, inhibition of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids, prevents the proinflammatory response ...
R. Carroll, Z. Zaslona, Silvia Galván-Peña, Emma L. Koppe, D. Sévin, Stefano Angiari, M. Triantafilou, K. Triantafilou, Louise K Modis, L. O’Neill   +9 more
semanticscholar   +1 more source

Alveolar Macrophage Plasminogen Activator

Experimental Lung Research, 1984
Plasminogen activator is a neutral serine protease secreted by many different cells, including activated peritoneal macrophages, which can mediate both inflammation and fibrinolysis and perhaps cytolysis of tumor cells. Secretion of plasminogen activator by rabbit alveolar macrophages derived from normal animals and rabbits pretreated with bacillus ...
M, Schuyler, W, Forman
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

M2-like macrophages in the fibrotic liver protect mice against lethal insults through conferring apoptosis resistance to hepatocytes. [PDF]

, 2017
Acute injury in the setting of liver fibrosis is an interesting and still unsettled issue. Most recently, several prominent studies have indicated the favourable effects of liver fibrosis against acute insults.
Bai, Li, Chen, Yu, Duan, Zhongping, Han, Yuan-Ping, Hu, Richard, Kong, Ming, Liu, Shuang, Liu, Xin, Lou, Jinli, Pandol, Stephen J, Ren, Feng, Zhang, Xiaohui, Zheng, Qingfen, Zheng, Sujun   +13 more
core   +2 more sources