Results 21 to 30 of about 128,741 (174)

Deriving a Boolean dynamics to reveal macrophage activation with in vitro temporal cytokine expression profiles

BMC Bioinformatics, 2019
Background Macrophages show versatile functions in innate immunity, infectious diseases, and progression of cancers and cardiovascular diseases. These versatile functions of macrophages are conducted by different macrophage phenotypes classified as ...
Ricardo Ramirez, Allen Michael Herrera, Joshua Ramirez, Chunjiang Qian, David W. Melton, Paula K. Shireman, Yu-Fang Jin   +6 more
doaj   +1 more source

In silico prediction of protein-protein interactions in human macrophages [PDF]

BMC Research Notes, BioMed Central, 2014, 7, pp.157, 2015
Background: Protein-protein interaction (PPI) network analyses are highly valuable in deciphering and understanding the intricate organisation of cellular functions. Nevertheless, the majority of available protein-protein interaction networks are context-less, i.e.
arxiv   +1 more source

Effects of mesoporous SiO2-CaO nanospheres on the murine peritoneal macrophages -- Candida albicans interface [PDF]

Int Immunopharmacol International Immunopharmacology. 2021 Mar 20;94:107457, 2021
The use of nanoparticles for intracellular drug delivery could reduce the toxicity and side effects of the drug but, the uptake of these nanocarriers could induce adverse effects on cells and tissues after their incorporation. Macrophages play a central role in host defense and are responsible for in vivo nanoparticle trafficking.
arxiv   +1 more source

Deep RNA Sequencing Uncovers a Repertoire of Human Macrophage Long Intergenic Noncoding RNAs Modulated by Macrophage Activation and Associated With Cardiometabolic Diseases

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundSustained and dysfunctional macrophage activation promotes inflammatory cardiometabolic disorders, but the role of long intergenic noncoding RNA (lincRNA) in human macrophage activation and cardiometabolic disorders is poorly defined.
Hanrui Zhang, Chenyi Xue, Ying Wang, Jianting Shi, Xuan Zhang, Wenjun Li, Sara Nunez, Andrea S. Foulkes, Jennie Lin, Christine C. Hinkle, Wenli Yang, Edward E. Morrisey, Daniel J. Rader, Mingyao Li, Muredach P. Reilly   +14 more
doaj   +1 more source

Activation of GPER1 in macrophages ameliorates UUO-induced renal fibrosis

Cell Death and Disease, 2023
Numerous studies have proven the critical role of macrophages in the renal fibrosis process. Notably, G Protein-coupled Estrogen Receptor 1 (GPER1), a novel estrogen receptor, has been shown to play a ubiquitous role in regulating macrophage activities ...
Lin Xie, Ye Cheng, Wen Du, Lili Fu, Zhaonan Wei, Yuting Guan, Yi Wang, Changlin Mei, Chuanming Hao, Min Chen, Xiangchen Gu   +10 more
doaj   +1 more source

Vaccination with Leishmania mexicana LPG induces PD-1 in CD8+ and PD-L2 in macrophages thereby suppressing the immune response: A model to assess vaccine efficacy [PDF]

Vaccine Volume 32, Issue 11, 5 March 2014, Pages 1259-1265, 2019
Leishmania lipophosphoglycan is a molecule that has been used as a vaccine candidate, with contradictory results. Since unsuccessful protection could be related to suppressed T cell responses, we analyzed the expression of inhibitory receptor PD-1 in CD8+ and CD4+ lymphocytes and it is ligand PD-L2 in macrophages of BALB/c mice immunized with various ...
arxiv   +1 more source

Segmentation based tracking of cells in 2D+time microscopy images of macrophages [PDF]

, 2023
The automated segmentation and tracking of macrophages during their migration are challenging tasks due to their dynamically changing shapes and motions. This paper proposes a new algorithm to achieve automatic cell tracking in time-lapse microscopy macrophage data.
arxiv   +1 more source

Alpha 7 nicotinic acetylcholine receptors signaling boosts cell-cell interactions in macrophages effecting anti-inflammatory and organ protection

Communications Biology, 2023
Activation of the cholinergic anti-inflammatory pathway (CAP) via vagus nerve stimulation has been shown to improve acute kidney injury in rodent models.
Yasuna Nakamura, Hirotaka Matsumoto, Chia-Hsien Wu, Daichi Fukaya, Rie Uni, Yosuke Hirakawa, Mikako Katagiri, Shintaro Yamada, Toshiyuki Ko, Seitaro Nomura, Youichiro Wada, Issei Komuro, Masaomi Nangaku, Reiko Inagi, Tsuyoshi Inoue   +14 more
doaj   +1 more source

A chemotaxis reaction-diffusion model for Multiple Sclerosis with Allee effect [PDF]

arXiv, 2023
In this paper, we study a modification of the mathematical model describing inflammation and demyelination patterns in the brain caused by Multiple Sclerosis proposed in [Lombardo et al. (2017), Journal of Mathematical Biology, 75, 373--417]. In particular, we hypothesize a minimal amount of macrophages to be able to start and sustain the inflammatory ...
arxiv  

Non-Gaussianity and Dynamical Trapping in Locally Activated Random Walks [PDF]

Phys. Rev E 85, 021137 (2012), 2011
We propose a minimal model of \emph{locally-activated diffusion}, in which the diffusion coefficient of a one-dimensional Brownian particle is modified in a prescribed way --- either increased or decreased --- upon each crossing of the origin. Such a local mobility decrease arises in the formation of atherosclerotic plaques due to diffusing macrophage ...
arxiv   +1 more source