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Macrophage Activation Syndrome in Children: Diagnosis and Management [PDF]
Indian Pediatrics, 2021 Macrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality.
Bagri, Narendra Kumar +3 more
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Rheumatology, 2014 Macrophage activation syndrome (MAS), a rare complication of various diseases, mainly systemic inflammatory connective tissue disorders, is being increasingly recognized.
Marzena Janczewska +1 more
doaj +2 more sources
Macrophage activation syndrome: early diagnosis is key
Open Access Rheumatology: Research and Reviews, 2018 Butsabong Lerkvaleekul, Soamarat Vilaiyuk Division of Rheumatology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand Abstract: Macrophage activation syndrome (MAS) is a life-threatening condition ...
Lerkvaleekul B, Vilaiyuk S
doaj +1 more source
Macrophage activation syndrome: A cause of unresponsive malaria
Mediterranean Journal of Hematology and Infectious Diseases, 2014 Macrophage activation syndrome (MAS) results from inappropriate proliferation and activation of cells of the macrophage-histiocytic lineage. Severe infections, autoimmune diseases and malignancies are known to trigger MAS in otherwise healthy individuals.
Manish Bhagat +5 more
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Macrophage Activation Syndrome
International Journal of Surgical Pathology, 2013 Macrophage activation syndrome (MAS) is an infrequent but potentially life-threatening complication of various autoimmune diseases. It is characterized by excessive activation of macrophages induced by a dysfunction of the immune system, although the underlying abnormalities remain to be delineated.
Nidhi, Aggarwal, Rohit, Aggarwal
+8 more sources
mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome
Nature Communications, 2022 Still’s disease is an inflammatory syndrome linked to the development of further immune dysregulation and hypercytokinaemia termed macrophage activation syndrome.
Zhengping Huang +30 more
doaj +1 more source
Macrophage activation syndrome in COVID-19
Акушерство, гинекология и репродукция, 2021 The novel coronavirus epidemic is characterized by high rates of morbidity and relatively high mortality. Laboratory test results in patients include leukopenia, an increase in liver function tests and ferritin levels reaching hundreds, and sometimes ...
K. N. Grigorieva +11 more
doaj +1 more source
Journal of Medical Case Reports, 2021 Background Macrophage activation syndrome is classified as a secondary form of hemophagocytic lymphohistiocytosis. It is a hyperinflammatory complication observed to be comorbid with a variety of autoimmune diseases, including adult-onset Still’s disease
Wesam Gouda +5 more
doaj +1 more source
Adult-onset Still’s disease with secondary macrophage activation syndrome: a case report
Italian Journal of Medicine, 2023 We describe a case of adult-onset Still’s disease (AOSD) with secondary macrophage activation syndrome. AOSD is a rare disease with unknown origin. Rarely it’s complicated by secondary macrophage activation syndrome, which is a life-threatening disorder.
Giuseppe Nicoletti +7 more
doaj +1 more source
Macrophage activation syndrome revealing Hodgkin´s lymphoma: a case report
The Pan African Medical Journal, 2021 Macrophage activation syndrome (MAS) is a rare immunologic syndrome, rapidly fatal in the absence of specific etiological treatment. It is defined by clinical, biological and cyto-histological criteria. Numerous etiologies have been described in MAS, the
Mustapha Mechtoune +2 more
doaj +1 more source