Results 11 to 20 of about 260,356 (192)

Heterogeneity of macrophage activation syndrome and treatment progression

Frontiers in Immunology
Macrophage activation syndrome (MAS) is a rare complication of autoimmune inflammatory rheumatic diseases (AIIRD) characterized by a progressive and life-threatening condition with features including cytokine storm and hemophagocytosis.
Yuanji Dong, Ting Wang, Huaxiang Wu
doaj   +3 more sources

Macrophage activation syndrome complicating early course of adult-onset Still’s disease [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2021
Introduction. Adult-onset Still’s disease is a rare inflammatory disorder of unknown etiology. It can be complicated by macrophage activation syndrome, a potentially life-threatening condition. While macrophage activation syndrome and adult-onset Still’s
Božić Ksenija, Elez Marija, Glišić Branislava   +2 more
doaj   +1 more source

Macrophage Activation Syndrome

International Journal of Surgical Pathology, 2013
Macrophage activation syndrome (MAS) is an infrequent but potentially life-threatening complication of various autoimmune diseases. It is characterized by excessive activation of macrophages induced by a dysfunction of the immune system, although the underlying abnormalities remain to be delineated.
Nidhi, Aggarwal, Rohit, Aggarwal
  +8 more sources

Macrophage Activation Syndrome in Children: Diagnosis and Management [PDF]

Indian Pediatrics, 2021
Macrophage activation syndrome is a severe yet under-recognized complication encountered in pediatric rheumatology. It manifests as secondary hemophagocytic lymphohistiocytosis leading to a hyper-inflammatory state resulting from an underlying cytokine storm. If unchecked, it may lead to multiorgan failure and mortality.
Bagri, Narendra Kumar, Gupta, Latika, Sen, Ethan S, Ramanan, A V   +3 more
openaire   +3 more sources

mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome

Nature Communications, 2022
Still’s disease is an inflammatory syndrome linked to the development of further immune dysregulation and hypercytokinaemia termed macrophage activation syndrome.
Zhengping Huang, Xiaomeng You, Liang Chen, Yan Du, Kailey Brodeur, Hyuk Jee, Qiang Wang, Grace Linder, Roxane Darbousset, Pierre Cunin, Margaret H. Chang, Alexandra Wactor, Brian M. Wauford, Marc J. C. Todd, Kevin Wei, Ying Li, Anais Levescot, Yoichiro Iwakura, Virginia Pascual, Nicole E. Baldwin, Pierre Quartier, Tianwang Li, Maria T. Gianatasio, Robert P. Hasserjian, Lauren A. Henderson, David B. Sykes, Elizabeth D. Mellins, Scott W. Canna, Julia F. Charles, Peter A. Nigrovic, Pui Y. Lee   +30 more
doaj   +1 more source

Macrophage activation syndrome in COVID-19

Акушерство, гинекология и репродукция, 2021
The novel coronavirus epidemic is characterized by high rates of morbidity and relatively high mortality. Laboratory test results in patients include leukopenia, an increase in liver function tests and ferritin levels reaching hundreds, and sometimes ...
K. N. Grigorieva, V. O. Bitsadze, J. Kh. Khizroeva, M. V. Tretyakova, D. V. Blinov, V. I. Tsibizova, D. A. Ponomarev, A. S. Shkoda, E. A. Orudzhova, E. Grandone, G. Rizzo, A. D. Makatsariya   +11 more
doaj   +1 more source

Macrophage activation syndrome triggered by systemic lupus erythematosus flare: successful treatment with a combination of dexamethasone sodium phosphate, intravenous immunoglobulin, and cyclosporine: a case report

Journal of Medical Case Reports, 2021
Background Macrophage activation syndrome is classified as a secondary form of hemophagocytic lymphohistiocytosis. It is a hyperinflammatory complication observed to be comorbid with a variety of autoimmune diseases, including adult-onset Still’s disease
Wesam Gouda, Faisal Alsaqabi, Abdelhfeez Moshrif, Awad S. Abbas, Tarek M. Abdel-Aziz, Md Asiful Islam   +5 more
doaj   +1 more source

Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern. The fragile balance between infections and autoimmunity [PDF]

, 2020
On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency.
Diamanti, A. P., Lagana, B., Pioli, C., Rosado, M. M., Sesti, G.   +4 more
core   +2 more sources

Adult-onset Still’s disease with secondary macrophage activation syndrome: a case report

Italian Journal of Medicine, 2023
We describe a case of adult-onset Still’s disease (AOSD) with secondary macrophage activation syndrome. AOSD is a rare disease with unknown origin. Rarely it’s complicated by secondary macrophage activation syndrome, which is a life-threatening disorder.
Giuseppe Nicoletti, Antonio Bonelli, Rocco Clemente, Simona Ciuffreda, Gaetano Dentamaro, Agata Tiziana La Masa, Vito Lascaro, Pasquale Santarcangelo   +7 more
doaj   +1 more source

Macrophage activation syndrome revealing Hodgkin´s lymphoma: a case report

The Pan African Medical Journal, 2021
Macrophage activation syndrome (MAS) is a rare immunologic syndrome, rapidly fatal in the absence of specific etiological treatment. It is defined by clinical, biological and cyto-histological criteria. Numerous etiologies have been described in MAS, the
Mustapha Mechtoune, Rajae Tissir, Ilias Tazi   +2 more
doaj   +1 more source