Results 41 to 50 of about 1,228,727 (302)
Macrophage polarization in tissue fibrosis
PeerJ, 2023 Fibrosis can occur in all major organs with relentless progress, ultimately leading to organ failure and potentially death. Unfortunately, current clinical treatments cannot prevent or reverse tissue fibrosis. Thus, new and effective antifibrotic therapeutics are urgently needed.
Huidan Yang +5 more
openaire +3 more sources
The Role of M1/M2 Macrophage Polarization in Rheumatoid Arthritis Synovitis
Frontiers in Immunology, 2022 Innate and adaptive immunity represent a harmonic counterbalanced system involved in the induction, progression, and possibly resolution of the inflammatory reaction that characterize autoimmune rheumatic diseases (ARDs), including rheumatoid arthritis ...
M. Cutolo +3 more
semanticscholar +1 more source
Macrophage Polarization in Inflammatory Diseases [PDF]
International Journal of Biological Sciences, 2014 Diversity and plasticity are two hallmarks of macrophages. M1 macrophages (classically activated macrophages) are pro-inflammatory and have a central role in host defense against infection, while M2 macrophages (alternatively activated macrophages) are associated with responses to anti-inflammatory reactions and tissue remodeling, and they represent ...
Yong-ming Yao +3 more
openaire +3 more sources
Macrophage plasticity, polarization, and function in health and disease
Journal of Cellular Physiology, 2018 Macrophages are heterogeneous and their phenotype and functions are regulated by the surrounding micro‐environment. Macrophages commonly exist in two distinct subsets: 1) Classically activated or M1 macrophages, which are pro‐inflammatory and polarized ...
A. Shapouri-Moghaddam +9 more
semanticscholar +1 more source
Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2β (group VIA phospholipase A2)* [PDF]
, 2016 Macrophages are important in innate and adaptive immunity. Macrophage participation in inflammation or tissue repair is directed by various extracellular signals and mediated by multiple intracellular pathways.
Ashley, Jason W +7 more
core +2 more sources
Obesity induces a phenotypic switch in adipose tissue macrophage polarization.
Journal of Clinical Investigation, 2007 Adipose tissue macrophages (ATMs) infiltrate adipose tissue during obesity and contribute to insulin resistance. We hypothesized that macrophages migrating to adipose tissue upon high-fat feeding may differ from those that reside there under normal diet ...
C. Lumeng, Jennifer L Bodzin, A. Saltiel
semanticscholar +1 more source
Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
Nature Communications, 2021 Macrophages perform diverse functions within tissues during immune responses to pathogens and injury, but molecular mechanisms by which physical properties of the tissue regulate macrophage behavior are less well understood.
Hamza Atcha +11 more
semanticscholar +1 more source
Cell Death and Disease, 2023 Reprogramming of macrophages toward an M1 phenotype is a novel strategy to induce anticancer immunity. However, the regulatory mechanisms of M1 macrophage polarization and its functional roles in nasopharyngeal carcinoma (NPC) progression need to be ...
Huai Liu +7 more
doaj +1 more source
Macrophage Polarization in Bacterial Infections [PDF]
The Journal of Immunology, 2008 AbstractConverging studies have shown that M1 and M2 macrophages are functionally polarized in response to microorganisms and host mediators. Gene expression profiling of macrophages reveals that various Gram-negative and Gram-positive bacteria induce the transcriptional activity of a “common host response,” which includes genes belonging to the M1 ...
Benoit, Marie +2 more
openaire +4 more sources
Tumor-Associated Macrophage Subsets: Shaping Polarization and Targeting
International Journal of Molecular Sciences, 2023 The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the most abundant cell population and are present at all stages of tumor ...
Qindong Zhang, M. Sioud
semanticscholar +1 more source