Results 41 to 50 of about 166,541 (336)

High iodine promotes autoimmune thyroid disease by activating hexokinase 3 and inducing polarization of macrophages towards M1

Frontiers in Immunology, 2022
Autoimmune thyroid disease (AITD), the most common autoimmune disease, includes Graves’ disease (GD) and Hashimoto’s thyroiditis (HT). Currently, the pathogenesis of AITD is not fully understood.
Tiantian Cai, Peng Du, Lixia Suo, Xiaozhen Jiang, Qiu Qin, Ronghua Song, Xiaorong Yang, Yanfei Jiang, Jin-an Zhang   +8 more
doaj   +1 more source

Bisdemethoxycurcumin and Its Cyclized Pyrazole Analogue Differentially Disrupt Lipopolysaccharide Signalling in Human Monocyte-Derived Macrophages [PDF]

, 2018
open11noSeveral studies suggest that curcumin and related compounds possess antioxidant and anti-inflammatory properties including modulation of lipopolysaccharide- (LPS-) mediated signalling in macrophage cell models. We here investigated the effects of

core   +1 more source

Macrophage polarization and allergic asthma [PDF]

Translational Research, 2018
Allergic asthma is associated with airway inflammation and airway hyperresponsiveness. Macrophage polarization has been shown to have a profound impact on asthma pathogenesis. On exposure to local microenvironments, recruited macrophages can be polarized into either classically activated (or M1) or alternatively activated (or M2) phenotypes. Macrophage
Arjun Saradna, Danh C. Do, Shruthi Kumar, Qing-Ling Fu, Peisong Gao   +4 more
openaire   +2 more sources

Evolutionary Aspects of Macrophages Polarization [PDF]

, 2017
Macrophages constitute a heterogeneous population of myeloid cells that are essential for maintaining homeostasis and as a first line of innate responders controlling and organizing host defenses against pathogens. Monocyte-macrophage lineage cells are among the most functionally diverse and plastic cells of the immune system.
Eva-Stina, Edholm, Kun Hyoe, Rhoo, Jacques, Robert   +2 more
openaire   +2 more sources

MiR-19a-3p Suppresses M1 Macrophage Polarization by Inhibiting STAT1/IRF1 Pathway

Frontiers in Pharmacology, 2021
Macrophages, an important type of immune cells, are generally polarized to classically activated macrophage (M1) or alternatively activated macrophage (M2) to respond to environmental stimuli. Signal transducer and activator of transcription 1 (STAT1), a
Xiaoxiao Zhu, Xiaoxiao Zhu, Xiaoxiao Zhu, Qiang Guo, Qiang Guo, Qiang Guo, Jing Zou, Bin Wang, Zhen Zhang, Zhen Zhang, Zhen Zhang, Ran Wei, Ran Wei, Ran Wei, Lin Zhao, Lin Zhao, Lin Zhao, Yunhong Zhang, Yunhong Zhang, Chu Chu, Chu Chu, Xiaoxiao Fu, Xiaoxiao Fu, Xia Li, Xia Li, Xia Li   +25 more
doaj   +1 more source

Dectin-1 Activation Exacerbates Obesity and Insulin Resistance in the Absence of MyD88 [PDF]

, 2017
This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, grant numbers 11/15682-4, 12/02270-2, 15/18121-4), Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Regenera INCT Process Grant 465656/2014-5 ...
Aguiar, Cristhiane Favero, Albuquerque, José Antonio T., Almeida, Rafael Ribeiro, Amano, Mariane Tami, Andrade-Oliveira, Vinicius, Belchior, Thiago, Braga, Tarcio Teodoro, Brown, Gordon D, Castoldi, Angela, Câmara, Niels Olsen Saraiva, da Silva, Marina Burgos, Festuccia, Willian T., Gaiarsa, Jonas W., Hiyane, Meire Ioshie, Hoffmann, Christian, Ignácio, Aline, Latância, Marcela Teatin, Lee, Jennifer, Lima, Joanna Darck Carola C., Loures, Flávio V, Macêdo, Marina Barguil, Martínez, Luis A. Luévano, Miyagi, Marcelli Terumi, Moraes-Vieira, Pedro Manoel, Mori, Marcelo A., Seelaender, Marília   +25 more
core   +5 more sources

Polarizing Macrophages In Vitro

, 2018
Macrophages are a heterogeneous population of innate myeloid cells involved in health and disease, which are the most functionally diverse cells of the hematopoietic system. The main functions of macrophages include responding to pathogens and modulating the adaptive immune response, induction and resolution of inflammation, tissue repair, and ...
Xuan, Huang, Yong, Li, Mingui, Fu, Hong-Bo, Xin   +3 more
openaire   +3 more sources

Tumor-induced senescent T cells promote the secretion of pro-inflammatory cytokines and angiogenic factors by human monocytes/macrophages through a mechanism that involves Tim-3 and CD40L [PDF]

, 2014
Solid tumors are infiltrated by immune cells where macrophages and senescent T cells are highly represented. Within the tumor microenvironment, a cross-talk between the infiltrating cells may occur conditioning the characteristic of the in situ immune ...
Acosta Rodriguez, Eva Virginia, Canale, Fernando Pablo, Gastman, B, Gruppi, Adriana, Mena, Hebe Agustina, Montes, Carolina Lucia, Negrotto, Soledad, Ramello, María Cecilia, Tosello Boari, Jimena   +8 more
core   +5 more sources

Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients

BMC Immunology, 2021
Background Differential polarization of macrophage into M1 and M2 mediates atherosclerotic plaque clearance through efferocytosis. Higher expression of Mer proto-oncogene tyrosine kinase (MerTK) on M2 macrophage helps in maintaining macrophage ...
Fatin Najiah Mohd Idrus, Nurul Shuhadah Ahmad, Chee Hock Hoe, Maryam Azlan, Farisha Alia Norfuad, Zurkurnai Yusof, Wan Yus Haniff Wan Isa, Akbar Ali Mohamed Ali, Get Bee Yvonne-Tee   +8 more
doaj   +1 more source

Modulators of the Balance between M1 and M2 Macrophages during Pregnancy [PDF]

, 2017
Macrophages are a subset of mononuclear phagocytes of the innate immune system with high plasticity and heterogeneity. At the maternal–fetal interface, macrophages are present in all stages of pregnancy and involved in a variety of activities, including ...
Ai-Hua Liao, Ming He, Yan Wang, Yong-Hong Zhang   +3 more
core   +1 more source