Results 11 to 20 of about 2,020,072 (390)
The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid. [PDF]
, 2014 We previously defined macrophages harvested from the peritoneal cavity of nude mice with subcutaneous human pancreatic tumors as "tumor-educated-macrophages" (Edu) and macrophages harvested from mice without tumors as "naïve-macrophages" (Naïve), and ...
Bouvet, Michael +17 more
core +17 more sources
Distinct Responses to IL4 in Macrophages Mediated by JNK
Cells, 2023 IL(Interleukin)-4 is the main macrophage M2-type activator and induces an anti-inflammatory phenotype called alternative activation. The IL-4 signaling pathway involves the activation of STAT (Signal Transducer and Activator of Transcription)-6 and ...
Luís Arpa +5 more
doaj +1 more source
GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation
Cells, 2022 At inflammatory loci, pro-inflammatory activation of macrophages produces large amounts of reactive oxygen species (ROS) that induce DNA breaks and apoptosis. Given that M-CSF and GM-CSF induce two different pathways in macrophages, one for proliferation
Tania Vico +6 more
doaj +1 more source
Macrophages in immunoregulation and therapeutics
Signal Transduction and Targeted Therapy, 2023 Macrophages exist in various tissues, several body cavities, and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers.
Shanze Chen +7 more
semanticscholar +1 more source
eLife, 2022 Nicotinamide adenine dinucleotide phosphate (NADPH) is the primary electron donor for reductive reactions that are essential for the biosynthesis of major cell components in all organisms.
Clarisse Leseigneur +6 more
doaj +1 more source
Macrophages as tools and targets in cancer therapy
Nature reviews. Drug discovery, 2022 Tumour-associated macrophages are an essential component of the tumour microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix remodelling, cancer cell proliferation, metastasis and immunosuppression, as well as in ...
A. Mantovani +3 more
semanticscholar +1 more source
Frontiers in Immunology, 2021 Matrix stiffness, a critical physical property of the cellular environment, is implicated in epidermal homeostasis. In particular, matrix stiffening during the pathological progression of skin diseases appears to contribute to cellular responses of ...
Hyewon Chung +8 more
doaj +1 more source
M1/M2 macrophages and their overlaps – myth or reality?
Clinical science, 2023 Macrophages represent heterogeneous cell population with important roles in defence mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations adopt distinct activation states.
Z. Strizova +6 more
semanticscholar +1 more source
In silico prediction of protein-protein interactions in human macrophages [PDF]
BMC Research Notes, 2001 Protein-protein interaction (PPI) network analyses are highly valuable in deciphering and understanding the intricate organisation of cellular functions.
Oussema Souiai +4 more
semanticscholar +1 more source
Metabolism, metabolites, and macrophages in cancer
Journal of Hematology & Oncology, 2023 Tumour-associated macrophages (TAMs) are crucial components of the tumour microenvironment and play a significant role in tumour development and drug resistance by creating an immunosuppressive microenvironment.
Mengyuan Li +5 more
semanticscholar +1 more source