Results 11 to 20 of about 1,818,468 (377)
Frontiers in Physiology, 2018 Macrophages play key roles in all phases of adult wound healing, which are inflammation, proliferation, and remodeling. As wounds heal, the local macrophage population transitions from predominantly pro-inflammatory (M1-like phenotypes) to anti ...
Paulina Krzyszczyk +3 more
semanticscholar +3 more sources
Distinct Responses to IL4 in Macrophages Mediated by JNK
Cells, 2023 IL(Interleukin)-4 is the main macrophage M2-type activator and induces an anti-inflammatory phenotype called alternative activation. The IL-4 signaling pathway involves the activation of STAT (Signal Transducer and Activator of Transcription)-6 and ...
Luís Arpa +5 more
doaj +1 more source
GM-CSF Protects Macrophages from DNA Damage by Inducing Differentiation
Cells, 2022 At inflammatory loci, pro-inflammatory activation of macrophages produces large amounts of reactive oxygen species (ROS) that induce DNA breaks and apoptosis. Given that M-CSF and GM-CSF induce two different pathways in macrophages, one for proliferation
Tania Vico +6 more
doaj +1 more source
eLife, 2022 Nicotinamide adenine dinucleotide phosphate (NADPH) is the primary electron donor for reductive reactions that are essential for the biosynthesis of major cell components in all organisms.
Clarisse Leseigneur +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Matrix stiffness, a critical physical property of the cellular environment, is implicated in epidermal homeostasis. In particular, matrix stiffening during the pathological progression of skin diseases appears to contribute to cellular responses of ...
Hyewon Chung +8 more
doaj +1 more source
Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages
Nature reviews. Immunology, 2020 The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in ...
M. Merad, Jérôme C. Martin
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2022 Animal models are essential to understanding COVID-19 pathophysiology and for preclinical assessment of drugs and other therapeutic or prophylactic interventions.
Valerio Laghi +10 more
doaj +1 more source
The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by zoledronic acid. [PDF]
, 2014 We previously defined macrophages harvested from the peritoneal cavity of nude mice with subcutaneous human pancreatic tumors as "tumor-educated-macrophages" (Edu) and macrophages harvested from mice without tumors as "naïve-macrophages" (Naïve), and ...
Bouvet, Michael +17 more
core +6 more sources
Effects of mesoporous SiO2-CaO nanospheres on the murine peritoneal macrophages -- Candida albicans interface [PDF]
Int Immunopharmacol International Immunopharmacology. 2021 Mar
20;94:107457, 2021 The use of nanoparticles for intracellular drug delivery could reduce the toxicity and side effects of the drug but, the uptake of these nanocarriers could induce adverse effects on cells and tissues after their incorporation. Macrophages play a central role in host defense and are responsible for in vivo nanoparticle trafficking.
arxiv +1 more source
Macrophage anti-inflammatory behaviour in a multiphase model of atherosclerotic plaque development [PDF]
Bull Math Biol 85, 37 (2023), 2022 Atherosclerosis is an inflammatory disease characterised by the formation of plaques, which are deposits of lipids and cholesterol-laden macrophages that form in the artery wall. The inflammation is often non-resolving, due in large part to changes in normal macrophage anti-inflammatory behaviour that are induced by the toxic plaque microenvironment ...
arxiv +1 more source