Results 51 to 60 of about 821 (149)

Cell‐type‐aware regulatory landscapes governing monoterpene indole alkaloid biosynthesis in the medicinal plant Catharanthus roseus

New Phytologist, Volume 245, Issue 1, Page 347-362, January 2025.
Summary In plants, the biosynthetic pathways of some specialized metabolites are partitioned into specialized or rare cell types, as exemplified by the monoterpenoid indole alkaloid (MIA) pathway of Catharanthus roseus (Madagascar Periwinkle), the source of the anticancer compounds vinblastine and vincristine. In the leaf, the C.
Chenxin Li, Maite Colinas, Joshua C. Wood, Brieanne Vaillancourt, John P. Hamilton, Sophia L. Jones, Lorenzo Caputi, Sarah E. O'Connor, C. Robin Buell   +8 more
wiley   +1 more source

Molecular and Biochemical Analysis of a Madagascar Periwinkle Root-Specific Minovincinine-19-Hydroxy-O-Acetyltransferase [PDF]

Plant Physiology, 2001
Abstract The terminal steps in the biosynthesis of the monoterpenoid indole alkaloids vindoline and minovincinine are catalyzed by separate acetyl coenzyme A-dependent O-acetyltransferases in Madagascar periwinkle (Catharanthus roseus G. Don).
P, Laflamme, B, St-Pierre, , De Luca V
openaire   +2 more sources

Plant‐Based Biosynthesis of Metal and Metal Oxide Nanoparticles: An Update on Antimicrobial and Anticancer Activity

ChemBioEng Reviews, Volume 11, Issue 6, December 2024.
When it comes to finding novel ways to battle newly developing pathogenic strains and illnesses, nanoparticles are the first line of defense. Plant‐based nanoparticles are showing more significance over chemically or physically synthesized nanoparticles. Several plant species and their constituent parts have found several applications in medicine. They
Shruti Nandkishor Tanwar, Yatish R. Parauha, Yogesh There, Hendrik C. Swart, Sanjay J. Dhoble   +4 more
wiley   +1 more source

Vinca Alkaloids

International Journal of Preventive Medicine, 2013
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have a hypoglycemic as well as cytotoxic effects.
Maryam Moudi, Rusea Go, Christina Yong Seok Yien, Mohd Nazre   +3 more
doaj  

Genome‐based discovery of pachysiphine synthases in Tabernaemontana elegans

The Plant Journal, Volume 120, Issue 5, Page 1880-1900, December 2024.
Significance Statement While pachysiphine is a monoterpene indole alkaloid of high interest and the precursor of an anti‐Alzheimer compound, its biosynthesis involving the epoxidation of tabersonine remains uncharacterized. By sequencing and assembling the genome of Tabernaemontana elegans, we identified two P450s exhibiting a pachysiphine synthase ...
Enzo Lezin, Mickael Durand, Caroline Birer Williams, Ana Luisa Lopez Vazquez, Thomas Perrot, Nicolas Gautron, Julien Pétrignet, Clément Cuello, Hans J. Jansen, Florent Magot, Sarah Szwarc, Pierre Le Pogam, Mehdi A. Beniddir, Konstantinos Koudounas, Audrey Oudin, Benoit St‐Pierre, Nathalie Giglioli‐Guivarc'h, Chao Sun, Nicolas Papon, Michael Krogh Jensen, Ron P. Dirks, Sarah E. O'Connor, Sébastien Besseau, Vincent Courdavault   +23 more
wiley   +1 more source

Jasmonic Acid Effect on the Fatty Acid and Terpenoid Indole Alkaloid Accumulation in Cell Suspension Cultures of Catharanthus roseus

Molecules, 2014
The stress response after jasmonic acid (JA) treatment was studied in cell suspension cultures of Catharanthus roseus. The effect of JA on the primary and secondary metabolism was based on changes in profiles of fatty acids (FA) and terpenoid indole ...
Guitele Dalia Goldhaber-Pasillas, Natali Rianika Mustafa, Robert Verpoorte   +2 more
doaj   +1 more source

The evolution and history of Vinca alkaloids: From the Big Bang to the treatment of pediatric acute leukemia

Pediatric Blood &Cancer, Volume 71, Issue 11, November 2024.
Abstract An attractive flower from the island of Madagascar has in part saved the lives of thousands of children with acute lymphoblastic leukemia (ALL). Random mutations and alterations to the genome led to the evolution of genes encoding enzymes, which would provide the periwinkle flower an arsenal of secondary metabolites to survive within the ...
Jeffrey W. Taub, Steven A. Buck, Ana C. Xavier, Holly Edwards, Larry H. Matherly, Yubin Ge   +5 more
wiley   +1 more source

Nanotechnology for climate change mitigation: Enhancing plant resilience under stress environments

Journal of Plant Nutrition and Soil Science, Volume 187, Issue 5, Page 604-620, October 2024.
Abstract Background Nanotechnology, utilizing nanoparticles (NPs) with unique physicochemical properties, has significant potential in enhancing sustainable agriculture through innovations in plant nutrition, growth, and protection. Aims This review aims to assess how nanotechnology, particularly NPs, contributes to sustainable agriculture by improving
Abbas Shoukat, Britta Pitann, Muhammad Mubashar Zafar, Muhammad Awais Farooq, Muhammad Haroon, Allah Nawaz, Syed Wasiq Wahab, Zulfiqar Ahmad Saqib   +7 more
wiley   +1 more source

A REVIEW OF CATHARANTHUS ROSEUS: AFRICAN MADAGASCAR PERIWINKLE

Abstract: Catharanthus roseus is an evergreen plant that originated from the islands ofMadagascar. It is known for its antitumor, anti-diabetic, and anti-microbial effects. Many famousphytochemicals, such as vincristine and vinblastine, were isolated from the plant.
Belinda A. Amankwah, M. Wiafe-Kwagyan, Aquel Rene Lopez   +2 more
openaire   +1 more source

Development of efficient catharanthus roseus regeneration and transformation system using agrobacterium tumefaciens and hypocotyls as explants

BMC Biotechnology, 2012
Background As a valuable medicinal plant, Madagascar periwinkle (Catharanthus roseus) produces many terpenoid indole alkaloids (TIAs), such as vindoline, ajamlicine, serpentine, catharanthine, vinblastine and vincristine et al. Some of them are important
Wang Quan, Xing Shihai, Pan Qifang, Yuan Fang, Zhao Jingya, Tian Yuesheng, Chen Yu, Wang Guofeng, Tang Kexuan   +8 more
doaj   +1 more source