Results 131 to 140 of about 3,271,883 (209)

Binding site selection for the plant MADS domain protein AGL15: an in vitro and in vivo study.

The Journal of biological chemistry, 2003
AGL15 (for AGAMOUS-like 15) is currently the only reported member of the plant MADS domain family of transcriptional regulators that preferentially accumulates during embryo development. Additionally, AGL15 is one of the more divergent members of the MADS domain family, including within the DNA-binding domain.
Weining, Tang, Sharyn E, Perry
openaire   +1 more source

Additional file 16: of Comparative analysis of binding patterns of MADS-domain proteins in Arabidopsis thaliana

, 2018
Table S8. Number of CArG-boxes with and without mutations. Note that the CArG-boxes in this table all match to the motif of AG because these CArG-boxes were used for all mutation analyses. The total number of CArG-boxes therefore differs from that in Additional file 5: Table S4. (PDF 47 kb)
Aerts, Niels, de Bruijn, Suzanne, van Mourik, Hilda, Angenent, Gerco, van Dijk, Aalt   +4 more
openaire   +1 more source

C1qc Mediates Blood–Brain Barrier Disruption in a Mouse Model of Intracerebral Haemorrhage Through Microglia‐Derived Migrasomes

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Microglia‐derived migrasomes induce vascular endothelial pyroptosis through C1qc delivery, uncovering a novel mechanism of blood–brain barrier (BBB) disruption after intracerebral haemorrhage (ICH) and proposing a novel therapeutic strategy targeting extracellular vesicles (EVs).
Mengyuan Li, Zhihua Li, Dengpan Song, Fang Wang, Mengzhao Feng, Chi‐Tai Yeh, Tingting Zhai, Menghan Deng, Yanyan Sun, Junyang Wang, Xuemei Chen, Yating Wang, Qiong Yang, Moxin Wu, Xiaoping Yin, Junmin Wang, Jian Wang, Fuyou Guo   +17 more
wiley   +1 more source

Genomic Architecture of AP2/ERF Superfamily Genes in Marigold (Tagetes erecta) and Insights into the Differential Expression Patterns of AP2 Family Genes During Floral Organ Specification

Agronomy
The APETALA2/Ethylene-Responsive Factor (AP2/ERF) superfamily is one of the largest transcription factor families in plants, playing diverse roles in development, stress response, and metabolic regulation. Despite their ecological and economic importance,
Hang Li, Guoqing Chen, Shirui Hu, Cuicui Liu, Manzhu Bao, Yanhong He   +5 more
doaj   +1 more source

MADS floral integrators : Insights into molecular mechanisms of MADS domain proteins in the floral transition

, 2018
The main aim of this thesis is understanding the molecular regulation of flowering time in Arabidopsis thaliana. More specifically, we focus on of key regulatory genes of flowering that integrate several internal and external flowering signals and examine in detail how they are regulated at the transcriptional and post-transcriptional level.
openaire   +2 more sources

Additional file 5: of Comparative analysis of binding patterns of MADS-domain proteins in Arabidopsis thaliana

, 2018
Table S4. Unique and overlapping CArG-boxes in each dataset. CArG-boxes are defined as all non-overlapping CArG-box like motifs found for each of the eight proteins (see Fig. 1 for corresponding motifs). Note that the amount of CArG-boxes occurring in all datasets is not the same for each dataset.
Aerts, Niels, Bruijn, Suzanne De, Mourik, Hilda Van, Angenent, Gerco, Dijk, Aalt Van   +4 more
openaire   +1 more source

The Exceptions to the Central Dogma of Biology—Bending the Rules and Extending the Scope

Natural Sciences, Volume 6, Issue 4, October 2026.
ABSTRACT The central dogma is an organizing framework for how information flows in biological systems. First presented in 1957 by Francis Crick in his talk “On Protein Synthesis” as a fundamental hypothesis of how information is transferred from DNA to proteins but not out of proteins, it is now introduced in cell biology textbooks as three sequential ...
Anat Ben‐Zvi
wiley   +1 more source

Application of an Open‐Source Modular Framework for Pharmacokinetic, Pharmacodynamic, and Safety Simulations to Anti‐Tuberculosis Drugs

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 10, October 2026.
ABSTRACT Tuberculosis (TB) treatment requires long‐term multidrug regimens where dosing, efficacy, and safety optimization remain challenging. This tutorial establishes an integrated, open‐source, modular framework connecting high‐throughput PBPK (HT‐PBPK) simulations, mechanistic PBPK models, pharmacodynamic endpoints, and safety predictions for anti ...
Marco Siccardi, Nina Nauwelaerts, Raphaëlle Lesage, Diane Lefaudeux, Vanessa Baier, Venetia Karamitsou, Cleo Demeester, Miao‐Chan Huang, Alexander Kulesza, Stephan Schaller   +9 more
wiley   +1 more source

QuickProcess2: an integrated package for crystallography data visualization, processing and management at the GM/CA Structural Biology Facility

Journal of Applied Crystallography, Volume 59, Issue 5, Page 1746-1756, October 2026.
QuickProcess2 (QP2) unifies real‐time image visualization, automated multi‐pipeline data processing and experiment management into a single open‐source platform for synchrotron macromolecular crystallography beamlines, enabling live quality assessment and concurrent data reduction for both standard rotation and serial crystallography experiments.The ...
Qingping Xu, Mark C. Hilgart, Nagarajan Venugopalan, David Kissick, Michael Becker, Shenglan Xu, Oleg Makarov, Sergey Stepanov, Janet L. Smith, Robert F. Fischetti   +9 more
wiley   +1 more source

The role of emerin and LEM domain proteins in nuclear envelope assembly and cytoskeleton organisation [PDF]

, 2005
The nuclear envelope (NE) plays a fundamental role in the cell by separating nuclear from cytoplasmic activities, and mutations in NE proteins have been associated with a diverse array of diseases.
Saipingidou, Georgia, Salpingidou, Georgia   +1 more
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