Results 111 to 120 of about 9,732 (196)

An Integrated Micromirror System for High‐Throughput Multi‐Parametric Cell Imaging

Small Methods, Volume 10, Issue 15, 7 August 2026.
A sheathless optofluidic platform integrates 3D‐printed micromirrors for simultaneous brightfield and dual‐color fluorescence imaging. Leveraging two‐photon stereolithography for rapid, single‐step fabrication, the system enables high‐content intracellular mapping and translocation analysis at throughputs exceeding 3000 cells per second.
Yingchao Meng, Xiaobao Chao, Andrew J. deMello, Stavros Stavrakis   +3 more
wiley   +1 more source

Additional file 14: of Comparative analysis of binding patterns of MADS-domain proteins in Arabidopsis thaliana

, 2018
Figure S8. Heatmap of occurences of extensions of individual perfect CArG boxes. For each MADS TF, color indicates the percentage occurence of specific subsequences (per line). Red, zero occurence; the more yellow/white, the higher the percentage. (PDF 70 kb)
Aerts, Niels, de Bruijn, Suzanne, van Mourik, Hilda, Angenent, Gerco, van Dijk, Aalt   +4 more
openaire   +1 more source

Genomic Architecture of AP2/ERF Superfamily Genes in Marigold (Tagetes erecta) and Insights into the Differential Expression Patterns of AP2 Family Genes During Floral Organ Specification

Agronomy
The APETALA2/Ethylene-Responsive Factor (AP2/ERF) superfamily is one of the largest transcription factor families in plants, playing diverse roles in development, stress response, and metabolic regulation. Despite their ecological and economic importance,
Hang Li, Guoqing Chen, Shirui Hu, Cuicui Liu, Manzhu Bao, Yanhong He   +5 more
doaj   +1 more source

Red‐to‐Near‐Infrared Fluorescence Resonance Energy Transfer Reporters for Dual Imaging Applications

Small Methods, Volume 10, Issue 15, 7 August 2026.
Genetically encoded FRET biosensors reveal dynamic signaling in living cells, but overlapping spectra have limited the simultaneous monitoring of multiple pathways. We introduce a red‐to‐near infrared FRET pair, mRuby2/miRFP670nano3, compatible with existing reporters and enabling dual FLIM‐FRET without bleed‐through.
Van Thi‐Hong Tran, Frans Ek, Hasan Yassine, Rajalaxmi Behera, Vesa P. Hytönen, James R. W. Conway   +5 more
wiley   +1 more source

MADS floral integrators : Insights into molecular mechanisms of MADS domain proteins in the floral transition

, 2018
The main aim of this thesis is understanding the molecular regulation of flowering time in Arabidopsis thaliana. More specifically, we focus on of key regulatory genes of flowering that integrate several internal and external flowering signals and examine in detail how they are regulated at the transcriptional and post-transcriptional level.
openaire   +2 more sources

Additional file 3: of Comparative analysis of binding patterns of MADS-domain proteins in Arabidopsis thaliana

, 2018
Figure S1. Clustering of original peak sets and peaks sets after re-analysis. Hierarchical clustering with complete linkage (function hclust in R) was performed using as distance measure between two peak sets the average distance between peaks in one set and in the other. Peaks-sets after re-analysis are indicated with name of the transcription factor,
Aerts, Niels, de Bruijn, Suzanne, van Mourik, Hilda, Angenent, Gerco, van Dijk, Aalt   +4 more
openaire   +1 more source

Crystal structure of endo‐β‐1,6‐galactanase from Streptomyces avermitilis

Acta Crystallographica Section D, Volume 82, Issue 8, Page 962-971, August 2026.
The crystal structure of S. avermitilis endo‐β‐1,6‐galactanase belonging to GH30 subfamily 5 reveals the first structural framework for endo‐β‐1,6‐galactanase. The β‐1,6‐galactobiose‐bound complex identifies the catalytic subsites and a distal secondary sugar‐binding site, providing insight into β‐1,6‐galactan recognition.Endo‐β‐1,6‐galactanases ...
Zui Fujimoto, Naomi Kishine, Toshihisa Kotake, Satoshi Kaneko   +3 more
wiley   +1 more source

Binding site selection for the plant MADS domain protein AGL15: an in vitro and in vivo study.

The Journal of biological chemistry, 2003
AGL15 (for AGAMOUS-like 15) is currently the only reported member of the plant MADS domain family of transcriptional regulators that preferentially accumulates during embryo development. Additionally, AGL15 is one of the more divergent members of the MADS domain family, including within the DNA-binding domain.
Weining, Tang, Sharyn E, Perry
openaire   +1 more source

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, Volume 183, Issue 15, Page 4344-4363, August 2026.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

Safety and Pharmacokinetics of Single and Multiple Ascending Doses of Olamkicept up to 2400 mg in Healthy Men: Phase I, Randomized, Placebo‐Controlled, and Double‐Blind Trial

Clinical and Translational Science, Volume 19, Issue 8, August 2026.
ABSTRACT Olamkicept is a first‐in‐class fully human fusion protein that selectively inhibits trans interleukin (IL)‐6 signaling. Previous phase I clinical trials demonstrated that single doses up to 750 mg and multiple doses up to 600 mg were safe and well tolerated in healthy men and women.
Stanislav Ignatenko, Alla Radicke, Katharina Bruzelius, Michael Falkenberg, Lars‐Erik Kyhl, Signe Møgelmose, Arjun Ravi, Philippe Pinton   +7 more
wiley   +1 more source