Results 71 to 80 of about 3,272,357 (172)

Structural determinants of DNA recognition by plant MADS-domain transcription factors [PDF]

open access: yes, 2014
Plant MADS-domain transcription factors act as key regulators of many developmental processes. Despite the wealth of information that exists about these factors, the mechanisms by which they recognize their cognate DNA-binding site, called CArG-box ...
Angenent, G.C.   +12 more
core   +1 more source

Genome-wide characterization of the MADS-box gene family in Paeonia ostii and expression analysis of genes related to floral organ development

open access: yesBMC Genomics
Background Paeonia section Moutan DC. is a significant perennial subshrub, the ornamental value of which heavily depends on the type of flower it possesses.
Xueting Yang   +8 more
doaj   +1 more source

Identification of the MADS-Box Gene Family and Development of Simple Sequence Repeat Markers in Chimonanthus praecox

open access: yesPlants
Chimonanthus praecox, a traditional ornamental plant in China, is admired for its ability to bloom during the cold winter season and is recognized as an outstanding woody cut flower.
Huafeng Wu   +10 more
doaj   +1 more source

Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions

open access: yesBrain Pathology, EarlyView.
An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich   +5 more
wiley   +1 more source

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies [PDF]

open access: yes, 2012
Members of the MADS-box transcription factor family play essential roles in almost every developmental process in plants. Many MADS-box genes have conserved functions across the flowering plants, but some have acquired novel functions in specific species
Angenent, G.C.   +3 more
core   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

MADS Domain Proteins in Plant Development

open access: yes, 1997
The MADS domain (MCM1, AGAMOUS, DEFICIENS, and SRF, serum response factor) is a conserved DNA-binding/dimerization region present in a variety of transcription factors from different kingdoms. MADS box genes represent a large multigene family in vascular
Riechmann, José Luis   +1 more
core  

Transcriptome analysis of resistant soybean roots infected by Meloidogyne javanica

open access: yesGenetics and Molecular Biology, 2012
Soybean is an important crop for Brazilian agribusiness. However, many factors can limit its production, especially root-knot nematode infection.
Maria Eugênia Lisei de Sá   +7 more
doaj   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

open access: yesThe FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti   +11 more
wiley   +1 more source

Prompt Sensitivity in AI Writing: A Methodological Caution for Corpus‐Based Analysis of AI‐Generated Language

open access: yesThe Modern Language Journal, EarlyView.
ABSTRACT Recent corpus‐based studies suggest generative AI systems such as ChatGPT can approximate human patterns of interpersonal metadiscourse in argumentative writing. These conclusions are typically based on AI‐generated texts produced using a single prompt, despite AI output being highly sensitive to even minor changes in prompt specification ...
Peter Crosthwaite   +2 more
wiley   +1 more source

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