Specific and sensitive loop-mediated isothermal amplification (LAMP) method for Madurella strains, eumycetoma filamentous fungi causative agent. [PDF]
PLoS Neglected Tropical Diseases, 2023 BackgroundFilamentous fungi of the genus Madurella are the primary causative agents of mycetoma, a disease observed in tropical and subtropical regions. Since early diagnostics based on a morphological approach are difficult and have many shortcomings, a
Isato Yoshioka +5 more
doaj +7 more sources
Madurella tropicana and Madurella pseudomycetomatis identified as new causative agents of black grain eumycetoma in Senegal [PDF]
Medical Mycology Case ReportsThis study reports Madurella tropicana and Madurella pseudomycetomatis as pathogens causing eumycetoma in Senegal. The dominant species, Madurella mycetomatis, shares morphological features with both.
Maguette Faye +5 more
doaj +5 more sources
Protoplast-mediated transformation of Madurella mycetomatis using hygromycin resistance as a selection marker. [PDF]
PLoS Neglected Tropical DiseasesMadurella mycetomatis is the main cause of mycetoma, a chronic granulomatous infection for which currently no adequate therapy is available. To improve therapy, more knowledge on a molecular level is required to understand how M.
Saskia du Pré +6 more
doaj +5 more sources
Phylogenetic findings suggest possible new habitat and routes of infection of human eumyctoma. [PDF]
PLoS Neglected Tropical Diseases, 2013 Eumycetoma is a traumatic fungal infection in tropical and subtropical areas that may lead to severe disability. Madurella mycetomatis is one of the prevalent etiologic agents in arid Northeastern Africa.
G Sybren de Hoog +10 more
doaj +4 more sources
Identification of Microbial-Based Natural Products as Potential CYP51 Inhibitors for Eumycetoma Treatment: Insights from Molecular Docking, MM-GBSA Calculations, ADMET Analysis, and Molecular Dynamics Simulations [PDF]
PharmaceuticalsBackground/Objectives: Eumycetoma, caused by Madurella mycetomatis, is a chronic fungal infection with limited treatment options and increasing drug resistance.
Tilal Elsaman +4 more
doaj +2 more sources
A histopathological exploration of the Madurella mycetomatis grain. [PDF]
PLoS ONE, 2013 Although the Madurella mycetomatis grains seem to interfere with the host defense mechanisms and impede the antifungal drugs penetration, yet their histological features are not fully known and hence this study was set out to determine that.
Anahid Izzat Ibrahim +3 more
doaj +3 more sources
Itraconazole resistance in Madurella fahalii linked to a distinct homolog of the gene encoding cytochrome P450 14-α sterol demethylase (CYP51). [PDF]
PLoS Neglected Tropical DiseasesBackgroundMycetoma is a deep fungal infection caused by several microorganisms, with Madurella mycetomatis being the most common causative agent. Another related species, Madurella fahalii, is also known to cause eumycetoma.
Isato Yoshioka +4 more
doaj +2 more sources
Madurella mycetomatis is highly susceptible to ravuconazole. [PDF]
PLoS Neglected Tropical Diseases, 2014 The current treatment of eumycetoma utilizing ketoconazole is unsatisfactory because of high recurrence rates, which often leads to complications and unnecessary amputations, and its comparatively high cost in endemic areas.
Sarah Abdalla Ahmed +6 more
doaj +8 more sources
Phylogenetic analysis of the complete mitochondrial genome of Madurella mycetomatis confirms its taxonomic position within the order Sordariales. [PDF]
PLoS ONE, 2012 BACKGROUND: Madurella mycetomatis is the most common cause of human eumycetoma. The genus Madurella has been characterized by overall sterility on mycological media.
Wendy W J van de Sande
doaj +8 more sources
The contribution of mycetoma grains to suboptimal disease management [PDF]
Nature CommunicationsA defining feature of mycetoma is the presence of grains, which are dense, compact structures composed of the causative bacterial or fungal microorganisms.
Ahmed Hassan Fahal +3 more
doaj +2 more sources