Results 11 to 20 of about 1,486 (188)

Left Gluteal and Perianal Eumycetoma Lesion Extending Into the Left Greater Sciatic Foramen, Pelvic Cavity to the External Anal Sphincter [PDF]

Clinical Case Reports
Mycetoma is a chronic subcutaneous infection that primarily affects the lower extremities, although atypical anatomical presentations are possible.
Rawa Badri, Ahmed Hassan Fahal
doaj   +3 more sources

Kinome analysis of Madurella mycetomatis identified kinases in the cell wall integrity pathway as novel potential therapeutic drug targets in eumycetoma caused by Madurella mycetomatis. [PDF]

PLoS Neglected Tropical Diseases
Eumycetoma is a neglected tropical subcutaneous disease most commonly caused by the fungus Madurella mycetomatis. Currently, eumycetoma is treated by a combination of antifungal therapy and surgery, with limited success rates.
Mickey Konings, Nikolaos Strepis, Ri-Ichiroh Manabe, Akira Hasegawa, Somdatta Chaudhari, Saskia du Pré, Marij Schippers, Michihira Tagami, Jingyi Ma, Yasushi Okazaki, Matthew Todd, Bernhard Biersack, Vijay Masand, Annelies Verbon, Takeya Kasukawa, Imad Abugessaisa, Wendy W J van de Sande   +16 more
doaj   +3 more sources

Protoplast-mediated transformation of Madurella mycetomatis using hygromycin resistance as a selection marker. [PDF]

PLoS Neglected Tropical Diseases
Madurella mycetomatis is the main cause of mycetoma, a chronic granulomatous infection for which currently no adequate therapy is available. To improve therapy, more knowledge on a molecular level is required to understand how M.
Saskia du Pré, Mickey Konings, Dorenda J A Schoorl, Ahmed H Fahal, Mark Arentshorst, Arthur F J Ram, Wendy W J van de Sande   +6 more
doaj   +3 more sources

Antifungal Activity of Natural Naphthoquinones and Anthraquinones against Madurella mycetomatis

Chemistry &Biodiversity, Volume 20, Issue 5, May 2023., 2023
Abstract Eumycetoma, the fungal form of the neglected tropical disease mycetoma, is a crippling infectious disease with low response rates to currently available antifungal drugs. In this study, a series of natural naphthoquinones and anthraquinones was evaluated for their activity against Madurella mycetomatis, which is the most common causative agent
Jingyi Ma, Matthew Todd, Wendy W. J. van de Sande, Bernhard Biersack   +3 more
wiley   +2 more sources

Using a Madurella mycetomatis‐specific PCR on grains obtained via non‐invasive fine‐needle aspirated material is more accurate than cytology

Mycoses, Volume 66, Issue 6, Page 477-482, June 2023., 2023
Abstract Background Eumycetoma is a chronic subcutaneous inflammatory fungal infection most often caused by the fungus Madurella mycetomatis. Using a species‐specific PCR on DNA directly isolated from grains is currently the most reliable method for species identification.
Emmanuel Edwar Siddig, Ayman Ahmed, Omnia Babekir Hassan, Sahar Mubarak Bakhiet, Annelies Verbon, Ahmed Hassan Fahal, Wendy W. J. van de Sande   +6 more
wiley   +2 more sources

Epidemiological cut‐off values for itraconazole and ravuconazole for Madurella mycetomatis, the most common causative agent of mycetoma

Mycoses, Volume 65, Issue 12, Page 1170-1178, December 2022., 2022
Abstract Background Eumycetoma is a neglected tropical disease. It is a chronic inflammatory subcutaneous infection characterised by painless swellings which produce grains. It is currently treated with a combination of itraconazole and surgery. In an ongoing clinical study, the efficacy of fosravuconazole, the prodrug of ravuconazole, is being ...
Bertrand Nyuykonge, Emmanuel E. Siddig, Najwa Adam Mhmoud, Borna A. Nyaoke, Eduard E. Zijlstra, Annelies Verbon, Sahar Bakhiet, Ahmed H. Fahal, Wendy W. J. van de Sande   +8 more
wiley   +2 more sources

Wako β‐D‐glucan assay can be used to measure serum β‐D‐glucan in Sudanese patients to aid with diagnosis of eumycetoma caused by Madurella mycetomatis

Journal of the European Academy of Dermatology and Venereology, Volume 37, Issue 4, Page 783-786, April 2023., 2023
Abstract Background Eumycetoma is a neglected tropical infection of the subcutaneous tissue commonly caused by the fungus Madurella mycetomatis. Previously, we demonstrated that β‐D‐glucan was present in the serum of eumycetoma patients. Objective To compare the performance of the recently approved easy‐to‐use Wako β‐D‐glucan assay to that of the ...
Bertrand Nyuykonge, Emmanuel Siddig, Najwa A. Mhmoud, Sahar Bakhiet, Eduard Zijlstra, Annelies Verbon, Ahmed H. Fahal, Wendy W. J. van de Sande   +7 more
wiley   +2 more sources

Eumycetoma Caused by Madurella pseudomycetomatis in a Captive Tiger (Panthera tigris)

Journal of Fungi, 2022
A captive-kept adult male tiger presented with a large cutaneous and subcutaneous mass on the thigh with a fistula. During sedation, multiple nodules were detected and samples for a histopathological exam were collected.
Margherita Orlandi, Giuseppe Giglia, Patrizia Danesi, Piero Laricchiuta, Francesca Abramo   +4 more
doaj   +2 more sources

Eumycotic mycetoma due to Madurella grisea [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 1989
The authors reported one case of eumycotic mycetoma due to Madurella grisea (black grains) occurred on the right foot of the patient studied. The structure, microscopic morphology and therapeutic evolution are also studied and reported.
Walter Belda Júnior, Luis Carlos Cucé, Mabel Cristina Dias, Carlos da Silva Lacaz   +3 more
doaj   +3 more sources

A histopathological exploration of the Madurella mycetomatis grain.

PLoS ONE, 2013
Although the Madurella mycetomatis grains seem to interfere with the host defense mechanisms and impede the antifungal drugs penetration, yet their histological features are not fully known and hence this study was set out to determine that.
Anahid Izzat Ibrahim, Ahmed Mohammed El Hassan, Ahmed Fahal, Wendy W van de Sande   +3 more
doaj   +5 more sources