Results 21 to 30 of about 1,769 (180)

The Mycetoma Knowledge Gap: Identification of Research Priorities [PDF]

, 2014
Mycetoma is a tropical disease which is caused by a taxonomically diverse range of actinomycetes (actinomycetoma) and fungi (eumycetoma). The disease was only recently listed by the World Health Organization (WHO) as a neglected tropical disease (NTD ...
Fahal, Ahmed Hassan, Goodfellow, Michael, Maghoub, El Sheikh, Van de Sande, Wendy W. J., Wanke, Bodo, Welsh Lozano, Oliverio, Zijlstra, Ed E.   +6 more
core   +27 more sources

Complete Genome Sequence of the Itraconazole Decreased Susceptible Madurella fahalii Type-Strain CBS 129176. [PDF]

Mycopathologia
Madurella fahalii is a causative agent of the implantation mycosis mycetoma with decreased susceptibility to itraconazole, the preferred therapeutic drug to combat mycetoma. Here, we report the M.
Konings M, Gerrits van den Ende B, Raats MWJ, Fahal AH, van de Sande WWJ, Hagen F.   +5 more
europepmc   +5 more sources

Eumycetoma causative agents: A systematic review to inform the World Health Organization priority list of fungal pathogens. [PDF]

Med Mycol
The World Health Organization, in response to the growing burden of fungal disease, established a process to develop a fungal priority pathogens list. This systematic review aimed to evaluate the epidemiology and impact of eumycetoma.
Clark JE, Kim HY, van de Sande WWJ, McMullan B, Verweij P, Alastruey-Izquierdo A, Chakrabarti A, Harrison TS, Bongomin F, Hay RJ, Oladele R, Heim J, Beyer P, Galas M, Siswanto S, Dagne DA, Roitberg F, Gigante V, Beardsley J, Sati H, Alffenaar JW, Morrissey CO.   +21 more
europepmc   +4 more sources

Madurella mycetoma: a neglected tropical disease [PDF]

Clinical Microbiology and Infection, 2022
Abstract Eumycotic mycetoma or eumycetoma is a chronic cutaneous and subcutaneous granulomatous infection caused by various fungi. A 65 year old gentleman presented with a history of nodular swellings on the right foot with discharging sinuses of six years duration. Radiological features showed signs of osteomyelitis. Histopathological examination of
Poornima, Baby, Vipin, Mohan, Malini, Eapen, Anna, Kurian, Arya, Ramachandran, Balu C, Babu, Anil, Kumar   +6 more
openaire   +2 more sources

Recurrent abdominal wall mass in a hepatitis B‐positive male: An unusual case of lumbar mycetoma

Clinical Case Reports, Volume 11, Issue 12, December 2023., 2023
Key Clinical Message Atypical presentations of eumycetoma can pose a challenge in the diagnosis and treatment of the disease. Healthcare providers thorough in their differential diagnosis and investigations, even in the absence of classic symptoms, in order to improve early detection and the case management for such a neglected tropical disease ...
Alaa Tajeldeen Habeeb Abdallah, Rami Elsiddig Abdelkhalig, Elwasila Hamid, Ayman Ahmed, Emmanuel Edwar Siddig   +4 more
wiley   +1 more source

The impact of AlphaFold Protein Structure Database on the fields of life sciences

PROTEOMICS, Volume 23, Issue 17, September 2023., 2023
Abstract Arguably, 2020 was the year of high‐accuracy protein structure predictions, with AlphaFold 2.0 achieving previously unseen accuracy in the Critical Assessment of Protein Structure Prediction (CASP). In 2021, DeepMind and EMBL‐EBI developed the AlphaFold Protein Structure Database to make an unprecedented number of reliable protein structure ...
Mihaly Varadi, Sameer Velankar
wiley   +1 more source

Evaluation of the Antiparasitic and Antifungal Activities of Synthetic Piperlongumine‐Type Cinnamide Derivatives: Booster Effect by Halogen Substituents

ChemMedChem, Volume 18, Issue 12, June 15, 2023., 2023
Halo‐ed ground: New piperlongumine‐type cinnamides with halogen substituents and the potential to bind tubulin show considerable activities against Toxoplasma gondii and Leishmania major protozoal parasites, and moderate activity against Trypanosoma brucei and Madurella mycetomatis, depending on the halogen atom present.
Tariq A. Khan, Ibrahim S. Al Nasr, Waleed S. Koko, Jingyi Ma, Simon Eckert, Lucas Brehm, Ridha Ben Said, Ismail Daoud, Riadh Hanachi, Seyfeddine Rahali, Wendy W. J. van de Sande, Klaus Ersfeld, Rainer Schobert, Bernhard Biersack   +13 more
wiley   +1 more source

Eumicetoma por Madurella grisea: relato de caso

Revista da Sociedade Brasileira de Medicina Tropical, 1991
E relatado um caso de micetoma por Madurella grisea de localização podai em uma mulher do lar. A identificação da amostra foi feita através das características macro e microscópicas do agente em ágar Sabouraud e através da assimilação de açúcares. Este é
Maria do Rosário Rodrigues Silva, Orionalda de Fátima Lisboa Fernandes, Lilian Maria de Oliveira, Maurício Barcelos Costa, Lia Cândida de Castro   +4 more
doaj   +3 more sources

Using a Madurella mycetomatis‐specific PCR on grains obtained via non‐invasive fine‐needle aspirated material is more accurate than cytology

Mycoses, Volume 66, Issue 6, Page 477-482, June 2023., 2023
Abstract Background Eumycetoma is a chronic subcutaneous inflammatory fungal infection most often caused by the fungus Madurella mycetomatis. Using a species‐specific PCR on DNA directly isolated from grains is currently the most reliable method for species identification.
Emmanuel Edwar Siddig, Ayman Ahmed, Omnia Babekir Hassan, Sahar Mubarak Bakhiet, Annelies Verbon, Ahmed Hassan Fahal, Wendy W. J. van de Sande   +6 more
wiley   +1 more source

Screening the pandemic response box identified benzimidazole carbamates, Olorofim and ravuconazole as promising drug candidates for the treatment of eumycetoma.

PLoS Neglected Tropical Diseases, 2022
Eumycetoma is a chronic subcutaneous neglected tropical disease that can be caused by more than 40 different fungal causative agents. The most common causative agents produce black grains and belong to the fungal orders Sordariales and Pleosporales.
Wilson Lim, Bertrand Nyuykonge, Kimberly Eadie, Mickey Konings, Juli Smeets, Ahmed Fahal, Alexandro Bonifaz, Matthew Todd, Benjamin Perry, Kirandeep Samby, Jeremy Burrows, Annelies Verbon, Wendy van de Sande   +12 more
doaj   +1 more source