Results 51 to 60 of about 877 (163)

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

Phaeohyphomycosis caused by Trematosphaeria grisea in an immunocompromised English springer spaniel

Veterinary Record Case Reports, Volume 12, Issue 4, December 2024.
Abstract A 10‐year‐old, male, farm‐based springer spaniel that presented with subacute progressive left‐sided central vestibular signs was diagnosed with meningoencephalitis of unknown origin. The patient received prednisolone (2 mg/kg/day orally), ciclosporin (5 mg/kg orally twice a day) and a single infusion of cytarabine (200 mg/m2). Six weeks later,
Erin Brennan, Theofanis Liatis, Sian‐Marie Frosini, Elizabeth Johnson, Ross Bond   +4 more
wiley   +1 more source

Photokatalytische CO2 Reduktion mit CO2‐bindenden Enzymen

Angewandte Chemie, Volume 136, Issue 16, April 15, 2024.
Es wird eine neue, vielseitige Aktivität der Phenolsäure‐Decarboxylase aus Bacillus subtilis und anderer CO2‐bindender Enzyme beschrieben. Die Enzyme katalysieren die photokatalytische CO2‐Reduktion in Gegenwart eines Ru(bpy)3‐Photosensibilisators, wobei sie eine hohe Selektivität für die CO2‐Reduktion gegenüber der Protonenreduktion (bis zu 93 ...
Henrik Terholsen, Hilario Diego Huerta‐Zerón, Christina Möller, Henrik Junge, Matthias Beller, Uwe T. Bornscheuer   +5 more
wiley   +1 more source

Photocatalytic CO2 Reduction Using CO2‐Binding Enzymes

Angewandte Chemie International Edition, Volume 63, Issue 16, April 15, 2024.
A novel promiscuous activity of the phenolic acid decarboxylase from Bacillus subtilis and other CO2‐binding enzymes is described. The enzymes catalyze the photocatalytic CO2 reduction in the presence of a Ru(bpy)3 photosensitizer, exhibiting high selectivity for CO2 reduction over proton reduction (up to 93 %).
Henrik Terholsen, Hilario Diego Huerta‐Zerón, Christina Möller, Henrik Junge, Matthias Beller, Uwe T. Bornscheuer   +5 more
wiley   +1 more source

Using (1,3)‐β‐D‐glucan concentrations in serum to monitor the response of azole therapy in patients with eumycetoma caused by Madurella mycetomatis

Mycoses, Volume 67, Issue 1, January 2024.
Abstract Introduction (1,3)‐β‐D‐glucan is a panfungal biomarker secreted by many fungi, including Madurella mycetomatis, the main causative agent of eumycetoma. Previously we demonstrated that (1,3)‐β‐D‐glucan was present in serum of patients with eumycetoma.
Bertrand Nyuykonge, Emmanuel E. Siddig, Borna A. Nyaoke, Eduard E. Zijlstra, Annelies Verbon, Sahar M. Bakhiet, Ahmed H. Fahal, Wendy W. J. van de Sande   +7 more
wiley   +1 more source

A Retrospective Review of Neglected Tropical Diseases Diagnosed on Histopathological Specimens in the Free State Province, South Africa, 2015–2020

Journal of Tropical Medicine, Volume 2024, Issue 1, 2024.
Background. Neglected tropical diseases (NTDs) are a heterogeneous group of medical conditions that commonly occur in underprivileged populations. NTDs are primarily diagnosed in tropical areas. Although South Africa is not situated in a tropical region, the high poverty rate makes the country susceptible to some NTDs. Limited data are available on the
Danita Linda le Grange, She’neze Fatima Pillay, Liska Budding, Cornel van Rooyen, Jacqueline Goedhals, Faham Khamesipour   +5 more
wiley   +1 more source

Environmental detection of eumycetoma pathogens using multiplex real-time PCR for soil DNA in Sennar State, Sudan

Tropical Medicine and Health, 2023
Background Mycetoma is a chronic disease affecting the skin and subcutaneous tissue endemic in the tropical and subtropical regions. Several bacteria and fungi can cause mycetoma, but fungal mycetoma (eumycetoma) is challenging because the treatment ...
Hiroki Hashizume, Suguru Taga, Masayuki K. Sakata, Mahmoud Hussein, Emmanuel Edwar Siddig, Toshifumi Minamoto, Ahmed Hassan Fahal, Satoshi Kaneko   +7 more
doaj   +1 more source

The Accuracy of Histopathological and Cytopathological Techniques in the Identification of the Mycetoma Causative Agents.

PLoS Neglected Tropical Diseases, 2019
Mycetoma is a devastating neglected tropical disease, caused by various fungal and bacterial pathogens. Correct diagnosis to the species level is mandatory for proper treatment.
Emmanuel Edwar Siddig, Najwa Adam Mhmoud, Sahar Mubarak Bakhiet, Omnia Babekir Abdallah, Salwa Osman Mekki, Nadia I El Dawi, Wendy Van de Sande, Ahmed Hassan Fahal   +7 more
doaj   +1 more source

The genus Madurella: Molecular identification and epidemiology in Sudan.

PLoS Neglected Tropical Diseases, 2020
Eumycetoma (mycotic mycetoma) is the fungal form of mycetoma, a subcutaneous infection occurring in individuals living in endemic areas of the disease.
Elhadi A Ahmed, Bakri Y M Nour, Adam D Abakar, Samirah Hamid, Ahmed A Mohamadani, Mohamed Daffalla, Mogahid Mahmoud, Hisham N Altayb, Marie Desnos-Ollivier, Sybren de Hoog, Sarah A Ahmed   +10 more
doaj   +1 more source

In Vitro Susceptibility of Madurella mycetomatis to Posaconazole and Terbinafine [PDF]

Antimicrobial Agents and Chemotherapy, 2011
ABSTRACT Presently, therapy of eumycetoma in Sudan is still based on surgery combined with prolonged ketoconazole therapy. This usually results in a poor clinical outcome. To determine if posaconazole and terbinafine could offer better therapeutic alternatives, the in vitro susceptibilities of 34
Belkum, Alex, Fahal, AH, Laureijssen - van de Sande, Wendy   +2 more
openaire   +2 more sources