Results 41 to 50 of about 148,513 (305)
Universita Ciencia, 2014 El presente escrito propone un método de acercamiento diverso en nuestros tiempos, que posibilite el reconocimiento de la alteridad del alumno en su constitución e institución social.
Israel Ladrón de Guevara Calderón
doaj +1 more source
, 2019 Con la denominación de «rural», aplicada al maestro de enseñanza primaria, pueden significarse dos cosas, por lo menos, bastante distintas, aunque se refieran ambas a un aspecto diferencial. Una de ellas es más profunda y ambiciosa que la otra.
Redondo, Emilio
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Contenidos Filosóficos y Evaluación en Filosofía: una Apuesta para la Escuela Contemporánea
Praxis & SaberEl artículo presenta los resultados parciales de una investigación que indaga sobre Discursos y prácticas sobre contenidos filosóficos y evaluación en filosofía en la enseñanza de la filosofía y su relación con la formación de estudiantes en ...
Oscar Pulido Cortés +2 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Pensamiento Palabra y Obra, 2018 Este art.culo es el resultado de un proceso de investigaci.n que inicio en el a.o 2010 en la comuna trece de Cali, en el barrio los lagos I, con el grupo folclórico Integración Pacífico.
John Alexis Rengifo Carpintero +1 more
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MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Overview of a design of hydraulic protection and analysis of the executive issues: diversion of the Cavo Maestro at the Botte Paleocapa in the municipalities of Bosaro and Polesella (Rovigo) [PDF]
, 2022 openSintesi di un progetto di protezione idraulica caratterizzato dalla realizzazione di un by pass del Cavo Maestro con relativa botte sifone sottostante e relative opere complementari ed accessorie.
SCUDELLARO, IGOR
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