Results 21 to 30 of about 6,176 (260)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Un día de clase en un aula intercultural wixárika del norte de Jalisco
Sinéctica, 2018 En este trabajo describimos las condiciones socioculturales y educativas de una escuela intercultural bilingüe wixárika del norte de Jalisco. El interés principal es conocer de cerca cómo se instrumentalizan las acciones pedagógicas del programa ...
Gloria Esther Briceño Alcaraz +2 more
doaj +2 more sources
Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila
FEBS Letters, EarlyView.Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia +6 more
wiley +1 more source
Maestros en Colectivo. Una década de actividad pedagógica
Educación y Ciudad, 2015 Este artículo de experiencia es una apuesta por describir el proceso de gestación y los retos y alcances logrados, en más de una década, por el equipo de investigación pedagógica Maestros en Colectivo, grupo constituido por docentes pertenecientes a la ...
Maestros en Colectivo Maestros en Colectivo
doaj
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Educación, Formación e Investigación, 2016 El Proyecto se origina en el diálogo entre docentes del Instituto Superior de Formación Docente (ISFD) de la Escuela Normal Superior ―Maestros Argentinos‖.
Silvia Fabiana Luchessi +4 more
doaj
La relevancia de la Práctica Pedagógica en la formación inicial de docentes
Revista Agustina de EducaciónEl presente ensayo reconoce la importancia de las Prácticas Pedagógicas como un elemento para la conformación de la identidad del docente en formación inicial. A lo largo del tiempo el papel de la docencia se transforma conforme las demandas sociales lo
Sergio Hugo Hernández Belmonte
doaj +1 more source