Results 61 to 70 of about 29,084 (308)

Los saberes de los futuros docentes en torno a la planeación didáctica

IE Revista de Investigación Educativa de la REDIECH
La planeación didáctica es una actividad esencial para el docente en formación porque forma parte del trabajo que desarrollará durante todo su ejercicio profesional.
Sergio Hugo Hernández Belmonte
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

La autonomía curricular en la Nueva Escuela Mexicana

Acción y Reflexión Educativa
Este texto tiene el propósito de reflexionar en torno al papel de la autonomía curricular como un parteaguas para iniciar un proceso de resignificación del docente de Educación Primaria.
Sergio Hugo Hernández Belmonte
doaj   +1 more source

Tablero de Alicia: diseño conceptual para la gobernabilidad de la Zona Metropolitana del Valle de México

Investigaciones Geográficas, 2012
En este documento se exponen los conceptos básicos que ayudan a entender otra forma de gestionar la Zona Metropolitana del Valle de México (ZMVM). Con el objetivo de descifrar el comportamiento de los agentes que intervienen en la ZMVM se abordan los ...
Jesús Rodríguez Rodríguez, Ruth Miranda Guerrero   +1 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

El maestro exterior y el Maestro interior en Del Maestro

ScientiAmericana Revista Multidisciplinaria, 2019
San Agustín en su obra Del Maestro sólo reconoce a Dios como Maestro y rechaza la idea de que el maestro humano enseñe. Ante esta situación, el interrogante que surge es ¿qué tarea atañe al hombre en su rol de educador si sólo Dios es Maestro? El presente trabajo, luego de un recorrido de los conceptos más relevantes de Del Maestro, propone un análisis
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Penguatan Usaha UKM Bengkel Las Maestro Melalui Implementasi Tata Kelola Manajerial Berbasis Poac Di Kelurahan Merjosari Kota Malang

, 2021
Adya Hermawati, Choirul Anam, Survival Survival   +2 more
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source