Results 81 to 90 of about 27,445 (296)

El papel de la aprehensión de los actos de habla en la comprensión de los enunciados.

open access: yesPragmalingüística
La teoría de los actos de habla afirma que para comprender un enunciado, es necesario reconocerlo como un acto ilocutivo. Sperber y Wilson (1986) toman una postura contraria al respecto, pero ninguna de las dos propuestas presenta suficiente evidencia ...
Hugo García Macías
doaj   +1 more source

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

open access: yesMolecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova   +26 more
wiley   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

open access: yesMolecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li   +12 more
wiley   +1 more source

The free will of indifference at a particular physical world

open access: yesRevista MENDIVE, 2004
This article has the objective of promoting the different theses about the theory of the free way and sustains one of them, the one related with the fact that all that exists is well determined by a net of multiple and varied causes.
Miguel Espinosa
doaj  

Gut alterations in a chronic kidney disease rat model with diet‐induced vascular calcification

open access: yesFEBS Open Bio, EarlyView.
Chronic kidney disease (CKD) patients often suffer from intestinal and/or mineral and bone disorders. Using a rat model, we showed that uremic vascular calcification is associated with gut barrier alterations (decreased gut mucus production and Nlrp6 gene expression, increased gut inflammation), and plasma retention of gut‐origin uremic toxins (indoxyl
Piotr Bartochowski   +13 more
wiley   +1 more source

Ptpn2: A Critical Regulator of Paneth Cell Homeostasis. [PDF]

open access: yesCell Mol Gastroenterol Hepatol, 2023
Theiss AL.
europepmc   +1 more source

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

open access: yesFEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel   +3 more
wiley   +1 more source

How conceive knowledge of different subjects polyvalent French teachers of first grade?

open access: yesRevista MENDIVE, 2004
This article offers a look about how a French Institute related problems versatility in basic education are addressed.
Odile Espinosa
doaj  

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