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Maf1 phenotypes and cell physiology [PDF]
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2018 As a master regulator of transcription by RNA polymerase (Pol) III, Maf1 represses the synthesis of highly abundant non-coding RNAs as anabolic signals dissipate, as the quality or quantity of nutrients decreases, and under a wide range of cellular and environmental stress conditions.
Ian M Willis
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Maf1, a general negative regulator of RNA polymerase III in yeast [PDF]
Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms, 2013 tRNA synthesis by yeast RNA polymerase III (Pol III) is down-regulated under growth-limiting conditions. This control is mediated by Maf1, a global negative regulator of Pol III transcription. Conserved from yeast to man, Maf1 was originally discovered in Saccharomyces cerevisiae by a genetic approach.
Magdalena Boguta
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Maf1 regulates axonal regeneration of retinal ganglion cells after injury
Experimental Neurology, 2022Retinal ganglion cells (RGCs) are the sole output neurons that carry visual information from the eye to the brain. Due to various retinal and optic nerve diseases, RGC somas and axons are vulnerable to damage and lose their regenerative capacity. A basic question is whether the manipulation of a key regulator of RGC survival can protect RGCs from ...
Di Chen, Xian-Dong Liu, Ju Huang
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The role of Maf1 in age-associated phenotypes
2022mTOR is a nutrient sensory kinase that regulates lifespan. mTOR controls cell growth, proliferation, and metabolism in response to nutrient availability. mTOR regulates the Maf1 protein by phosphorylation. When dephosphorylated and activated, Maf1 functions as a master inhibitor of RNA Polymerase III to repress transcription of tRNAs and 5S rRNAs.
Jessie M. Nagle +2 more
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Integration of nutritional and stress signaling pathways by Maf1
Trends in Biochemical Sciences, 2007Repression of RNA polymerase III transcription under many conditions requires Maf1, a yeast protein with close sequence homologs in all eukaryotes. Three recent studies have identified key aspects of Maf1 regulation, which suggest that Maf1 integrates the responses from convergent nutritional and stress signaling pathways.
Ian M, Willis, Robyn D, Moir
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Regulation of RNA Polymerase III Transcription by Maf1 in Mammalian Cells
Journal of Molecular Biology, 2008RNA polymerase (pol) III produces essential components of the biosynthetic machinery; therefore, its output is tightly coupled with the rate of cell growth and proliferation. In Saccharomyces cerevisiae, Maf1 is an essential mediator of pol III repression in response to starvation.
Sarah J Goodfellow +2 more
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Maf1 Protein, Repressor of RNA Polymerase III, Indirectly Affects tRNA Processing [PDF]
Journal of Biological Chemistry, 2011 Maf1 is negative regulator of RNA polymerase III in yeast. We observed high levels of both primary transcript and end-matured, intron-containing pre-tRNAs in the maf1Δ strain. This pre-tRNA accumulation could be overcome by transcription inhibition, arguing against a direct role of Maf1 in tRNA maturation and suggesting saturation of processing ...
Tomasz W Turowski +2 more
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Biochemical Society Transactions, 2011
Yeast and mammalian MAF1 are both regulated by the TOR (target of rapamycin) pathway. However, the exact mechanisms of regulation diverge at TOR, with yeast Maf1 phosphorylated mainly by the TORC1 (TOR complex 1) substrate Sch9 kinase and mammalian MAF1 by mTORC1 (mammalian target of rapamycin complex 1) itself.
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Yeast and mammalian MAF1 are both regulated by the TOR (target of rapamycin) pathway. However, the exact mechanisms of regulation diverge at TOR, with yeast Maf1 phosphorylated mainly by the TORC1 (TOR complex 1) substrate Sch9 kinase and mammalian MAF1 by mTORC1 (mammalian target of rapamycin complex 1) itself.
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Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons [PDF]
Molecular and Cellular Neurosciences, 2010 The majority of fast inhibitory synaptic transmission in the mammalian nervous system is mediated by GABA(A) receptors (GABA(A)Rs). Here we report a novel interaction between the protein Maf1 and GABA(A)R beta-subunit intracellular domains. We find Maf1 to be highly expressed in brain and enriched in the hippocampus and cortex.
Katharine R Smith +2 more
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