Results 151 to 160 of about 2,035 (177)

IM-NSGAII: A novel approach to boost convergence speed and population diversity in multi-objective optimization. [PDF]

PLoS One
Jiang W, Xie Z.
europepmc   +1 more source

Combined family-based association and linkage analyses in families affected by attention-deficit hyperactivity disorder. [PDF]

Hum Genet
Justice CM, Ahn K, Jung B, Norman LJ, Sudre G, Sharp W, Bouyssi-Kobar M, Choudhury S, Gligorovic S, Kundzicz P, Acosta MT, Shaw P.   +11 more
europepmc   +1 more source

The role of virulence genes in <i>Campylobacter</i> pathogenicity: a perspective from the Gulf Cooperation Council countries. [PDF]

Front Cell Infect Microbiol
Mohamed MI, Khalifa HO, Habib I.
europepmc   +1 more source

Recruitment of Fpt1 to tRNA genes requires TFIIIB and the N-terminal TPR array of TFIIIC subunit τ131

van Breugel ME, Seifert-Davila W, Bakker MJ, Meeussen JVW, Hoogvliet IA, Cardona MN, van Welsem T, Ammerlaan D, Baudin F, Celie P, Lenstra TL, Müller CW, van Leeuwen F.   +12 more
europepmc   +1 more source

Regulation of RNA Polymerase III Transcription by Maf1 in Mammalian Cells

Journal of Molecular Biology, 2008
RNA polymerase (pol) III produces essential components of the biosynthetic machinery; therefore, its output is tightly coupled with the rate of cell growth and proliferation. In Saccharomyces cerevisiae, Maf1 is an essential mediator of pol III repression in response to starvation.
Matthieu Gérard, Theodoros Kantidakis, Olivier Lefebvre   +2 more
exaly   +4 more sources

MAF1: a new target of mTORC1

Biochemical Society Transactions, 2011
Yeast and mammalian MAF1 are both regulated by the TOR (target of rapamycin) pathway. However, the exact mechanisms of regulation diverge at TOR, with yeast Maf1 phosphorylated mainly by the TORC1 (TOR complex 1) substrate Sch9 kinase and mammalian MAF1 by mTORC1 (mammalian target of rapamycin complex 1) itself.
Annemieke A. Michels, Michels, A.A.
openaire   +5 more sources

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Maf1 regulates axonal regeneration of retinal ganglion cells after injury

Experimental Neurology, 2022
Retinal ganglion cells (RGCs) are the sole output neurons that carry visual information from the eye to the brain. Due to various retinal and optic nerve diseases, RGC somas and axons are vulnerable to damage and lose their regenerative capacity. A basic question is whether the manipulation of a key regulator of RGC survival can protect RGCs from ...
Di Chen, Dong-Fu Feng, Ju Huang
exaly   +3 more sources

Maf1-dependent transcriptional regulation of tRNAs prevents genomic instability and is associated with extended lifespan [PDF]

Aging Cell, 2020
Maf1 is the master repressor of RNA polymerase III responsible for transcription of tRNAs and 5S rRNAs. Maf1 is negatively regulated via phosphorylation by the mTOR pathway, which governs protein synthesis, growth control, and lifespan regulation in ...
Eishi Noguchi, Kazuhiro Shiozaki, Sydney Wilson   +2 more
exaly   +2 more sources

The role of Maf1 in age-associated phenotypes

2022
mTOR is a nutrient sensory kinase that regulates lifespan. mTOR controls cell growth, proliferation, and metabolism in response to nutrient availability. mTOR regulates the Maf1 protein by phosphorylation. When dephosphorylated and activated, Maf1 functions as a master inhibitor of RNA Polymerase III to repress transcription of tRNAs and 5S rRNAs.
Jessie M. Nagle, Eishi Noguchi, Christian Sell   +2 more
openaire   +1 more source