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Maf1 Protein, Repressor of RNA Polymerase III, Indirectly Affects tRNA Processing [PDF]
Journal of Biological Chemistry, 2011 Maf1 is negative regulator of RNA polymerase III in yeast. We observed high levels of both primary transcript and end-matured, intron-containing pre-tRNAs in the maf1Δ strain. This pre-tRNA accumulation could be overcome by transcription inhibition, arguing against a direct role of Maf1 in tRNA maturation and suggesting saturation of processing ...
Magdalena Boguta +2 more
exaly +3 more sources
Crystal Structure and Regulation of the Citrus Pol III Repressor MAF1 by Auxin and Phosphorylation [PDF]
Structure, 2017 MAF1 is the main RNA polymerase (Pol) III repressor that controls cell growth in eukaryotes. The Citrus ortholog, CsMAF1, was shown to restrict cell growth in citrus canker disease but its role in plant development and disease is still unclear. We solved the crystal structure of the globular core of CsMAF1, which reveals additional structural elements ...
Adriana Paes Leme +2 more
exaly +4 more sources
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Characterizing the physiological roles and regulatory mechanisms of Maf1
2015Obesity has become markedly more prevalent over the past two decades among developed countries however, the molecular events that connect obesity, lipid deregulation and human diseases are still unclear. Mammalian Maf1 was initially identified as a repressor of RNA Polymerase III-transcribed genes and studies have focused on examining it?s role in ...
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Mutation in a new gene MAF1 affects tRNA suppressor efficiency in Saccharomyces cerevisiae
Gene, 1997Mutation in the MAF1 gene was identified in a screen for decreased efficiency of tRNA suppressor SUP11 in the yeast Saccharomyces cerevisiae (Sc). maf1-1 mutation exerts a dual phenotypic effect: antisuppression and temperature sensitive (ts) respiratory growth.
M, Boguta, K, Czerska, T, Zoładek
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Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2018MAF1 was discovered as a master repressor of Pol III-dependent transcription in response to diverse extracellular signals, including growth factor, nutrient and stress. It is regulated through posttranslational mechanisms such as phosphorylation. A prominent upstream regulator of MAF1 is the mechanistic target of rapamycin (mTOR) pathway.
Shanshan, Zhang +3 more
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Novel roles for Maf1 in embryonic stem cell differentiation and adipogenesis
2016Maf1 represses transcription from select RNA Polymerase (Pol) II? and RNA Pol III?dependent genes. Our previous studies demonstrated that Maf1 functions as a tumor suppressor and it negatively regulates intracellular lipid accumulation. Together, these results identify Maf1 as an important link in between metabolism and cancer.
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