Results 111 to 120 of about 4,187 (189)

Genome-wide identification and mining elite allele variation of the Monoacylglycerol lipase (MAGL) gene family in upland cotton (Gossypium hirsutum L.)

BMC Plant Biology
Background Monoacylglycerol lipase (MAGL) genes belong to the alpha/beta hydrolase superfamily, catalyze the terminal step of triglyceride (TAG) hydrolysis, converting monoacylglycerol (MAG) into free fatty acids and glycerol.
Zhibin Zhou, Yao Chen, Mengyuan Yan, Shuqi Zhao, Feifei Li, Shuxun Yu, Zhen Feng, Libei Li   +7 more
doaj   +1 more source

Compound 4f, a novel brain-penetrant reversible monoacylglycerol inhibitor, ameliorates neuroinflammation, neuronal cell loss, and cognitive impairment in mice with kainic acid-induced neurodegeneration.

PLoS ONE
Neuroinflammation, a hallmark of neurodegenerative diseases, is associated with neuronal cell loss and cognitive dysfunction. Monoacylglycerol lipase (MAGL) is involved in neuroinflammation in the brain via the degradation of endocannabinoid 2 ...
Naoto Arimura, Chie Maeda, Kazunobu Aoyama, Namiko Yamaguchi, Ayumu Sugiura, Yasuko Takahashi, Ryouta Maeda, Tatsuya Ando, Makoto Kamata, Hideki Matsui, Maiko Tanaka   +10 more
doaj   +1 more source

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

, 2009
Δ9-Tetrahydrocannabinol (THC), the psychoactive component of marijuana, and other direct cannabinoid receptor (CB1) agonists produce a number of neurobehavioral effects in mammals that range from the beneficial (analgesia) to the untoward (abuse ...
Booker, L., Nomura, D. K., Lichtman, A. H., Jin, X., Sim-Selley, L. J., A. H. Lichtman, J. L. Wiley, X. Jin, D. M. Walentiny, Cravatt, B. F., L. Booker, R. E. Vann, L. J. Sim-Selley, J. Z. Long, B. F. Cravatt, Long, J. Z., J. J. Burston, D. K. Nomura, Wiley, J. L., Vann, R. E., Walentiny, D. M., Burston, J. J.   +21 more
core   +1 more source

Monoacylglycerol lipase (MAGL) [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Synthesis of benzoylpiperidine-based MAGL inhibitors as prospective anticancer agents

Monoacylglycerol lipase (MAGL) is a serine hydrolase enzyme involved in many biological processes, such as the degradation of 2-arachidonoylglycerol (2-AG), one of the most important endocannabinoid neurotransmitters.
LICARI, CRISTINA
core  

Monoglyceride lipase (MGLL; MAGL) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source

Potenziale attività terapeutica degli inibitori della MAGL, enzima del sistema endocannabinoide

, 2015
Il monoacilglicerolo lipasi (MAGL) è una serina idrolasi citosolica associata alla membrana, è espressa nel fegato e nel tessuto adiposo, ma la sua massima espressione è nel cervello, in particolare nelle regioni che comprendono il cervelletto, la ...
DAL CANTO, VALENTINA
core  

Synthesis and optimization of benzoylpiperidine derivatives as Monoacylglycerol Lipase (MAGL) inhibitors.

Monoacylglycerol lipase (MAGL) is nowadays acknowledged as the main enzyme responsible for the deactivation of the most abundant brain endocannabinoid, 2-arachidonoylglycerol (2-AG).
FERRISI, REBECCA
core  

Sviluppo di un approccio innovativo per lo screening virtuale di inibitori della MAGL e sintesi di inibitori a potenziale attività duale MAGL/FAAH

Il lavoro di tesi ha previsto lo studio, in prima battuta, della monoacilglicerolo Lipasi (MAGL), una serina idrolasi che svolge un ruolo importante nella degradazione del 2-arachidonoilglicerolo (2-AG), neurotrasmettitore endocannabinoide coinvolto in ...
DI STEFANO, MIRIANA
core  

Development of Glycoconjugated MAGL Inhibitors with Glucose-Dependent Antiproliferative Activity. [PDF]

Int J Mol Sci
Bononi G, Bertini F, Masoni S, Stefano MD, Mosca R, Felice F, Signore G, Minutolo F, Granchi C, Tuccinardi T, Di Bussolo V.   +10 more
europepmc   +1 more source